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CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals.
AIDS. 2008 Oct 01; 22(15):1937-41.AIDS

Abstract

OBJECTIVE

Studies have found that CD8 T-cell activation, as measured by CD38 expression, in HIV-1-infected individuals on suppressive therapy for longer than 12 months is not predictive of CD4 T-cell recovery. Owing to the fact that reconstitution of memory and naive T-cell populations occurs differentially over time, this study evaluated whether distinct memory/naive CD4 T-cell subsets correlated with CD38 on CD8 T-cells.

MATERIALS AND METHODS

Whole blood from 13 participants was used to evaluate activation phenotypic markers on CD8 lymphocytes and memory/naive phenotypes on CD4 lymphocytes. These HIV-1-infected individuals had stable CD4 cell counts for more than 1 year while on suppressive combination antiretroviral therapy.

RESULTS

The results demonstrate that CD4 central memory and naive cell populations contribute to the magnitude of CD4 T-cell reconstitution. CD4 central memory has a significant negative correlation with the percentage of CD38-activated CD8 T-cells.

CONCLUSION

This suggests that CD8 activation is important in CD4 recovery from a low CD4 T-cell nadir.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. mkolber@med.miami.edu

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18784457

Citation

Kolber, Michael A.. "CD38+CD8+ T-cells Negatively Correlate With CD4 Central Memory Cells in Virally Suppressed HIV-1-infected Individuals." AIDS (London, England), vol. 22, no. 15, 2008, pp. 1937-41.
Kolber MA. CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals. AIDS. 2008;22(15):1937-41.
Kolber, M. A. (2008). CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals. AIDS (London, England), 22(15), 1937-41. https://doi.org/10.1097/QAD.0b013e32830f97e2
Kolber MA. CD38+CD8+ T-cells Negatively Correlate With CD4 Central Memory Cells in Virally Suppressed HIV-1-infected Individuals. AIDS. 2008 Oct 1;22(15):1937-41. PubMed PMID: 18784457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals. A1 - Kolber,Michael A, PY - 2008/9/12/pubmed PY - 2008/12/17/medline PY - 2008/9/12/entrez SP - 1937 EP - 41 JF - AIDS (London, England) JO - AIDS VL - 22 IS - 15 N2 - OBJECTIVE: Studies have found that CD8 T-cell activation, as measured by CD38 expression, in HIV-1-infected individuals on suppressive therapy for longer than 12 months is not predictive of CD4 T-cell recovery. Owing to the fact that reconstitution of memory and naive T-cell populations occurs differentially over time, this study evaluated whether distinct memory/naive CD4 T-cell subsets correlated with CD38 on CD8 T-cells. MATERIALS AND METHODS: Whole blood from 13 participants was used to evaluate activation phenotypic markers on CD8 lymphocytes and memory/naive phenotypes on CD4 lymphocytes. These HIV-1-infected individuals had stable CD4 cell counts for more than 1 year while on suppressive combination antiretroviral therapy. RESULTS: The results demonstrate that CD4 central memory and naive cell populations contribute to the magnitude of CD4 T-cell reconstitution. CD4 central memory has a significant negative correlation with the percentage of CD38-activated CD8 T-cells. CONCLUSION: This suggests that CD8 activation is important in CD4 recovery from a low CD4 T-cell nadir. SN - 1473-5571 UR - https://www.unboundmedicine.com/medline/citation/18784457/CD38+CD8+_T_cells_negatively_correlate_with_CD4_central_memory_cells_in_virally_suppressed_HIV_1_infected_individuals_ L2 - https://doi.org/10.1097/QAD.0b013e32830f97e2 DB - PRIME DP - Unbound Medicine ER -