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Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study.

Abstract

OBJECTIVE

We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men.

METHODS

Information on ALAD genotype, lead measurements, potential confounders, and cognitive testing was collected from 982 participants. For each cognitive test and lead biomarker, we fit separate multiple linear regression models, which included an interaction term for ALAD genotype and the lead biomarker and adjusted for potential confounders.

RESULTS

With higher levels of tibia lead, ALAD 1-2/2-2 carriers exhibited worse performance on a spatial copying test in comparison with ALAD 1-1 carriers (P interaction = 0.03). However, there was no consistent pattern of an ALAD genotype-lead interaction for the other tests.

CONCLUSIONS

The results provide some evidence that ALAD genotype may modify the relation between lead and cognition among older men with low lead burden. However, future work in this area is needed to confirm these suggestive findings.

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  • Authors+Show Affiliations

    ,

    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. prajan@hsph.harvard.edu

    , , , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Body Burden
    Bone and Bones
    Cognition Disorders
    Enzymes
    Humans
    Lead
    Lead Poisoning
    Male
    Massachusetts
    Middle Aged
    Polymorphism, Genetic
    Porphobilinogen Synthase
    United States
    United States Department of Veterans Affairs
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    18784554

    Citation

    Rajan, Pradeep, et al. "Interaction of the Delta-aminolevulinic Acid Dehydratase Polymorphism and Lead Burden On Cognitive Function: the VA Normative Aging Study." Journal of Occupational and Environmental Medicine, vol. 50, no. 9, 2008, pp. 1053-61.
    Rajan P, Kelsey KT, Schwartz JD, et al. Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study. J Occup Environ Med. 2008;50(9):1053-61.
    Rajan, P., Kelsey, K. T., Schwartz, J. D., Bellinger, D. C., Weuve, J., Spiro, A., ... Wright, R. O. (2008). Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study. Journal of Occupational and Environmental Medicine, 50(9), pp. 1053-61. doi:10.1097/JOM.0b013e3181792463.
    Rajan P, et al. Interaction of the Delta-aminolevulinic Acid Dehydratase Polymorphism and Lead Burden On Cognitive Function: the VA Normative Aging Study. J Occup Environ Med. 2008;50(9):1053-61. PubMed PMID: 18784554.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study. AU - Rajan,Pradeep, AU - Kelsey,Karl T, AU - Schwartz,Joel D, AU - Bellinger,David C, AU - Weuve,Jennifer, AU - Spiro,Avron,3rd AU - Sparrow,David, AU - Smith,Thomas J, AU - Nie,Huiling, AU - Weisskopf,Marc G, AU - Hu,Howard, AU - Wright,Robert O, PY - 2008/9/12/pubmed PY - 2009/3/24/medline PY - 2008/9/12/entrez SP - 1053 EP - 61 JF - Journal of occupational and environmental medicine JO - J. Occup. Environ. Med. VL - 50 IS - 9 N2 - OBJECTIVE: We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men. METHODS: Information on ALAD genotype, lead measurements, potential confounders, and cognitive testing was collected from 982 participants. For each cognitive test and lead biomarker, we fit separate multiple linear regression models, which included an interaction term for ALAD genotype and the lead biomarker and adjusted for potential confounders. RESULTS: With higher levels of tibia lead, ALAD 1-2/2-2 carriers exhibited worse performance on a spatial copying test in comparison with ALAD 1-1 carriers (P interaction = 0.03). However, there was no consistent pattern of an ALAD genotype-lead interaction for the other tests. CONCLUSIONS: The results provide some evidence that ALAD genotype may modify the relation between lead and cognition among older men with low lead burden. However, future work in this area is needed to confirm these suggestive findings. SN - 1536-5948 UR - https://www.unboundmedicine.com/medline/citation/18784554/Interaction_of_the_delta_aminolevulinic_acid_dehydratase_polymorphism_and_lead_burden_on_cognitive_function:_the_VA_normative_aging_study_ L2 - http://Insights.ovid.com/pubmed?pmid=18784554 DB - PRIME DP - Unbound Medicine ER -