Tags

Type your tag names separated by a space and hit enter

Extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasm of the pancreas: prevalence, associated factors, and comparison with patients with other pancreatic cystic neoplasms.
Ann Surg Oncol. 2008 Nov; 15(11):3193-8.AS

Abstract

BACKGROUND

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is reported to have a high prevalence of extrapancreatic malignancy (EPM). The aims of this study were to evaluate the prevalence and associated factors of EPMs in IPMN patients and to compare these data with those of non-IPMN pancreatic cystic neoplasm (PCN) patients.

METHODS

The study included 385 PCN patients (210 IPMNs and 175 non-IPMNs) diagnosed from 1993 to 2007. PCN types, presence of EPMs, chronological relation of EPMs to PCN diagnosis, and their clinicopathological parameters were analyzed.

RESULTS

The prevalence of EPM was 33.8% for IPMNs and 12.0% for non-IPMN PCNs (P < 0.001). In the majority of patients with EPMs, PCNs were detected while undergoing workup for the EPMs. For IPMNs, age was associated with EPMs [odds ratio (OR) 1.05, P = 0.013]; malignant IPMN showed a borderline inverse association with EPMs (OR 0.50, P = 0.071). Multivariate analysis of entire PCN cohort demonstrated that age at PCN diagnosis (OR 1.05, P < 0.001) was positively associated with EPM; IPMN showed a borderline positive association with EPM (OR 1.88, P = 0.052). Malignant PCN (OR 0.40, P = 0.009) was inversely associated with EPM.

CONCLUSION

The EPM prevalence of IPMN patients was 33.8%. Advanced age at IPMN diagnosis was the only factor significantly associated with EPMs in our IPMN cohort. In our PCN cohort, advanced age at PCN diagnosis was associated with malignant PCN and IPMN showed a borderline positive association with EPM.

Authors+Show Affiliations

Division of Gastroenterology, Department of Internal Medicine, Seoul National University College of Medicine, 28 Yeongon-dong, Jongno-gu, Seoul 110-744, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18784959

Citation

Yoon, Won Jae, et al. "Extrapancreatic Malignancies in Patients With Intraductal Papillary Mucinous Neoplasm of the Pancreas: Prevalence, Associated Factors, and Comparison With Patients With Other Pancreatic Cystic Neoplasms." Annals of Surgical Oncology, vol. 15, no. 11, 2008, pp. 3193-8.
Yoon WJ, Ryu JK, Lee JK, et al. Extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasm of the pancreas: prevalence, associated factors, and comparison with patients with other pancreatic cystic neoplasms. Ann Surg Oncol. 2008;15(11):3193-8.
Yoon, W. J., Ryu, J. K., Lee, J. K., Woo, S. M., Lee, S. H., Park, J. K., Kim, Y. T., & Yoon, Y. B. (2008). Extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasm of the pancreas: prevalence, associated factors, and comparison with patients with other pancreatic cystic neoplasms. Annals of Surgical Oncology, 15(11), 3193-8. https://doi.org/10.1245/s10434-008-0143-4
Yoon WJ, et al. Extrapancreatic Malignancies in Patients With Intraductal Papillary Mucinous Neoplasm of the Pancreas: Prevalence, Associated Factors, and Comparison With Patients With Other Pancreatic Cystic Neoplasms. Ann Surg Oncol. 2008;15(11):3193-8. PubMed PMID: 18784959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasm of the pancreas: prevalence, associated factors, and comparison with patients with other pancreatic cystic neoplasms. AU - Yoon,Won Jae, AU - Ryu,Ji Kon, AU - Lee,Jun Kyu, AU - Woo,Sang Myung, AU - Lee,Sang Hyub, AU - Park,Joo Kyung, AU - Kim,Yong-Tae, AU - Yoon,Yong Bum, Y1 - 2008/09/11/ PY - 2008/07/08/received PY - 2008/08/12/accepted PY - 2008/08/11/revised PY - 2008/9/12/pubmed PY - 2009/1/30/medline PY - 2008/9/12/entrez SP - 3193 EP - 8 JF - Annals of surgical oncology JO - Ann Surg Oncol VL - 15 IS - 11 N2 - BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is reported to have a high prevalence of extrapancreatic malignancy (EPM). The aims of this study were to evaluate the prevalence and associated factors of EPMs in IPMN patients and to compare these data with those of non-IPMN pancreatic cystic neoplasm (PCN) patients. METHODS: The study included 385 PCN patients (210 IPMNs and 175 non-IPMNs) diagnosed from 1993 to 2007. PCN types, presence of EPMs, chronological relation of EPMs to PCN diagnosis, and their clinicopathological parameters were analyzed. RESULTS: The prevalence of EPM was 33.8% for IPMNs and 12.0% for non-IPMN PCNs (P < 0.001). In the majority of patients with EPMs, PCNs were detected while undergoing workup for the EPMs. For IPMNs, age was associated with EPMs [odds ratio (OR) 1.05, P = 0.013]; malignant IPMN showed a borderline inverse association with EPMs (OR 0.50, P = 0.071). Multivariate analysis of entire PCN cohort demonstrated that age at PCN diagnosis (OR 1.05, P < 0.001) was positively associated with EPM; IPMN showed a borderline positive association with EPM (OR 1.88, P = 0.052). Malignant PCN (OR 0.40, P = 0.009) was inversely associated with EPM. CONCLUSION: The EPM prevalence of IPMN patients was 33.8%. Advanced age at IPMN diagnosis was the only factor significantly associated with EPMs in our IPMN cohort. In our PCN cohort, advanced age at PCN diagnosis was associated with malignant PCN and IPMN showed a borderline positive association with EPM. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/18784959/Extrapancreatic_malignancies_in_patients_with_intraductal_papillary_mucinous_neoplasm_of_the_pancreas:_prevalence_associated_factors_and_comparison_with_patients_with_other_pancreatic_cystic_neoplasms_ L2 - https://dx.doi.org/10.1245/s10434-008-0143-4 DB - PRIME DP - Unbound Medicine ER -