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Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study.
Mov Disord. 2008 Dec 15; 23(16):2335-43.MD

Abstract

Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one-back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21-face stimuli (activation condition) and three blocks of 21-colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyrus. A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli.

Authors+Show Affiliations

Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18785653

Citation

Ramírez-Ruiz, Blanca, et al. "Brain Response to Complex Visual Stimuli in Parkinson's Patients With Hallucinations: a Functional Magnetic Resonance Imaging Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 16, 2008, pp. 2335-43.
Ramírez-Ruiz B, Martí MJ, Tolosa E, et al. Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study. Mov Disord. 2008;23(16):2335-43.
Ramírez-Ruiz, B., Martí, M. J., Tolosa, E., Falcón, C., Bargalló, N., Valldeoriola, F., & Junqué, C. (2008). Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study. Movement Disorders : Official Journal of the Movement Disorder Society, 23(16), 2335-43. https://doi.org/10.1002/mds.22258
Ramírez-Ruiz B, et al. Brain Response to Complex Visual Stimuli in Parkinson's Patients With Hallucinations: a Functional Magnetic Resonance Imaging Study. Mov Disord. 2008 Dec 15;23(16):2335-43. PubMed PMID: 18785653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study. AU - Ramírez-Ruiz,Blanca, AU - Martí,María-José, AU - Tolosa,Eduardo, AU - Falcón,Carlos, AU - Bargalló,Nuria, AU - Valldeoriola,Francesc, AU - Junqué,Carme, PY - 2008/9/13/pubmed PY - 2009/4/9/medline PY - 2008/9/13/entrez SP - 2335 EP - 43 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 23 IS - 16 N2 - Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one-back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21-face stimuli (activation condition) and three blocks of 21-colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyrus. A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18785653/Brain_response_to_complex_visual_stimuli_in_Parkinson's_patients_with_hallucinations:_a_functional_magnetic_resonance_imaging_study_ L2 - https://doi.org/10.1002/mds.22258 DB - PRIME DP - Unbound Medicine ER -