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Intravenous iron in chronic kidney disease: haemoglobin change shortly after treatment of patients neither on dialysis nor on erythropoietin.
J Ren Care. 2008 Sep; 34(3):112-5.JR

Abstract

Anaemia is a common in chronic kidney disease. Although erythropoietin and iron supplementation are established treatments, knowledge on the use of IV iron alone in patients not on dialysis or erythropoietin is incomplete. The responses of 82 patients referred to the renal anaemia service with haemoglobin of 11.5 g/dl or less were assessed 1 week after completing four once weekly doses of 200 mg of venofer. No patients were on dialysis or erythropoietin. The haemoglobin rise 1 week after treatment was 0.53 g/dl. Ferritin levels improved from 110.8 to 410.2 ng/l and transferrin saturation from 17.7 to 27.3%. Ferritin levels remained below our target range (200-500 ng/l) in 7.7% while 25.6% had levels above this. Ferritin levels remained less than 800 ng/l in nearly all patients. Intravenous iron is cost effective and should be considered for use in patients with renal anaemia. Patients with CKD stage 5 appeared to respond less well.

Authors+Show Affiliations

Department of Nephrology, University Hospital of North Staffordshire, Royal Infirmary, Stoke on Trent, United Kingdom. senyo.tagboto@uhns.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18786076

Citation

Tagboto, Senyo, et al. "Intravenous Iron in Chronic Kidney Disease: Haemoglobin Change Shortly After Treatment of Patients Neither On Dialysis nor On Erythropoietin." Journal of Renal Care, vol. 34, no. 3, 2008, pp. 112-5.
Tagboto S, Cropper L, Mostafa S, et al. Intravenous iron in chronic kidney disease: haemoglobin change shortly after treatment of patients neither on dialysis nor on erythropoietin. J Ren Care. 2008;34(3):112-5.
Tagboto, S., Cropper, L., Mostafa, S., Turner, J., Bailey, G., & Pugh-Clarke, K. (2008). Intravenous iron in chronic kidney disease: haemoglobin change shortly after treatment of patients neither on dialysis nor on erythropoietin. Journal of Renal Care, 34(3), 112-5. https://doi.org/10.1111/j.1755-6686.2008.00026.x
Tagboto S, et al. Intravenous Iron in Chronic Kidney Disease: Haemoglobin Change Shortly After Treatment of Patients Neither On Dialysis nor On Erythropoietin. J Ren Care. 2008;34(3):112-5. PubMed PMID: 18786076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous iron in chronic kidney disease: haemoglobin change shortly after treatment of patients neither on dialysis nor on erythropoietin. AU - Tagboto,Senyo, AU - Cropper,Liz, AU - Mostafa,Samiul, AU - Turner,June, AU - Bailey,Georgina, AU - Pugh-Clarke,Karen, PY - 2008/9/13/pubmed PY - 2008/11/11/medline PY - 2008/9/13/entrez SP - 112 EP - 5 JF - Journal of renal care JO - J Ren Care VL - 34 IS - 3 N2 - Anaemia is a common in chronic kidney disease. Although erythropoietin and iron supplementation are established treatments, knowledge on the use of IV iron alone in patients not on dialysis or erythropoietin is incomplete. The responses of 82 patients referred to the renal anaemia service with haemoglobin of 11.5 g/dl or less were assessed 1 week after completing four once weekly doses of 200 mg of venofer. No patients were on dialysis or erythropoietin. The haemoglobin rise 1 week after treatment was 0.53 g/dl. Ferritin levels improved from 110.8 to 410.2 ng/l and transferrin saturation from 17.7 to 27.3%. Ferritin levels remained below our target range (200-500 ng/l) in 7.7% while 25.6% had levels above this. Ferritin levels remained less than 800 ng/l in nearly all patients. Intravenous iron is cost effective and should be considered for use in patients with renal anaemia. Patients with CKD stage 5 appeared to respond less well. SN - 1755-6678 UR - https://www.unboundmedicine.com/medline/citation/18786076/Intravenous_iron_in_chronic_kidney_disease:_haemoglobin_change_shortly_after_treatment_of_patients_neither_on_dialysis_nor_on_erythropoietin_ L2 - https://doi.org/10.1111/j.1755-6686.2008.00026.x DB - PRIME DP - Unbound Medicine ER -