Tags

Type your tag names separated by a space and hit enter

[The impact of sepsis bundles on mortality in patients with sepsis shock: a prospective clinical study].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Sep; 20(9):534-7.ZW

Abstract

OBJECTIVE

To survey the impact of sepsis bundle on prognosis of septic shock.

METHODS

From January 2007 to June 2008, a prospective clinical study was conducted on consecutive adult patients with sepsis shock in intensive care unit (ICU). The study of sepsis bundle on septic shock was divided into before training (from January to September 2007) and trained phases (from October 2007 to June 2008), and the patients were divided into control group and death group. The relationship between sepsis bundle index and prognosis at 6 hours and 24 hours was analyzed with logistic regression analysis. The independent factors of death due to septic shock were looked for. The compliance of sepsis bundles, duration of mechanical ventilation (MV), ICU stay, and 28-day mortality were noted.

RESULTS

One hundred patients, including 51 patients before training and 49 patients after training were enrolled for study. Thirty-six patients survived and 64 patients died. All the patients met the criteria for the diagnosis of sepsis shock. Through analysis of the parameters with logistic regression, it could be found that 6-hour early goal-directed therapy (EGDT) and 24-hour EGDT were the two independent protective factors of death, and standardized regression coefficient was 0.046 and 0.120 respectively (both P < 0.01). Compliance with sepsis bundles was low in training phase, the compliance increased apparently after training. Among them, 6-hour EGDT and 24-hour EGDT compliance increased to 55.1%, 65.3% from 19.6%, 35.3% (both P < 0.01). Compared with the group before training, the duration of MV [(166.6+/-156.4) hours vs. (113.6+/-73.6) hours], that of ICU stay [(9.4+/-7.6) days vs. (6.0+/-3.9) days] and 28-day mortality (72.5% vs. 55.1%, P < 0.05 or P < 0.01) was significantly lower after training.

CONCLUSION

Sepsis bundle is able to improve survival rate in patients in septic shock. Compliance with sepsis bundles is low before training, and training can improve the compliance and decrease mortality rate of septic shock.

Authors+Show Affiliations

Chen QH
Department of Criticial Care Medicine, Subei Hospital of Jiangsu Provience, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China. chenqihong00@163.com
Zheng RQ
No affiliation info available
Lin H
No affiliation info available
Wang HL
No affiliation info available
Lu NF
No affiliation info available
Shao J
No affiliation info available
Yu JQ
No affiliation info available

MeSH

AgedClinical ProtocolsCritical CareFemaleGuideline AdherenceHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisOutcome and Process Assessment, Health CarePrognosisProspective StudiesRegression AnalysisShock, SepticSurvival Analysis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18786312

Citation

Chen, Qi-hong, et al. "[The Impact of Sepsis Bundles On Mortality in Patients With Sepsis Shock: a Prospective Clinical Study]." Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, vol. 20, no. 9, 2008, pp. 534-7.
Chen QH, Zheng RQ, Lin H, et al. [The impact of sepsis bundles on mortality in patients with sepsis shock: a prospective clinical study]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008;20(9):534-7.
Chen, Q. H., Zheng, R. Q., Lin, H., Wang, H. L., Lu, N. F., Shao, J., & Yu, J. Q. (2008). [The impact of sepsis bundles on mortality in patients with sepsis shock: a prospective clinical study]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 20(9), 534-7.
Chen QH, et al. [The Impact of Sepsis Bundles On Mortality in Patients With Sepsis Shock: a Prospective Clinical Study]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008;20(9):534-7. PubMed PMID: 18786312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The impact of sepsis bundles on mortality in patients with sepsis shock: a prospective clinical study]. AU - Chen,Qi-hong, AU - Zheng,Rui-qiang, AU - Lin,Hua, AU - Wang,Hua-ling, AU - Lu,Nian-fang, AU - Shao,Jun, AU - Yu,Jiang-quan, PY - 2008/9/13/pubmed PY - 2010/2/19/medline PY - 2008/9/13/entrez SP - 534 EP - 7 JF - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue JO - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue VL - 20 IS - 9 N2 - OBJECTIVE: To survey the impact of sepsis bundle on prognosis of septic shock. METHODS: From January 2007 to June 2008, a prospective clinical study was conducted on consecutive adult patients with sepsis shock in intensive care unit (ICU). The study of sepsis bundle on septic shock was divided into before training (from January to September 2007) and trained phases (from October 2007 to June 2008), and the patients were divided into control group and death group. The relationship between sepsis bundle index and prognosis at 6 hours and 24 hours was analyzed with logistic regression analysis. The independent factors of death due to septic shock were looked for. The compliance of sepsis bundles, duration of mechanical ventilation (MV), ICU stay, and 28-day mortality were noted. RESULTS: One hundred patients, including 51 patients before training and 49 patients after training were enrolled for study. Thirty-six patients survived and 64 patients died. All the patients met the criteria for the diagnosis of sepsis shock. Through analysis of the parameters with logistic regression, it could be found that 6-hour early goal-directed therapy (EGDT) and 24-hour EGDT were the two independent protective factors of death, and standardized regression coefficient was 0.046 and 0.120 respectively (both P < 0.01). Compliance with sepsis bundles was low in training phase, the compliance increased apparently after training. Among them, 6-hour EGDT and 24-hour EGDT compliance increased to 55.1%, 65.3% from 19.6%, 35.3% (both P < 0.01). Compared with the group before training, the duration of MV [(166.6+/-156.4) hours vs. (113.6+/-73.6) hours], that of ICU stay [(9.4+/-7.6) days vs. (6.0+/-3.9) days] and 28-day mortality (72.5% vs. 55.1%, P < 0.05 or P < 0.01) was significantly lower after training. CONCLUSION: Sepsis bundle is able to improve survival rate in patients in septic shock. Compliance with sepsis bundles is low before training, and training can improve the compliance and decrease mortality rate of septic shock. SN - 1003-0603 UR - https://www.unboundmedicine.com/medline/citation/18786312/[The_impact_of_sepsis_bundles_on_mortality_in_patients_with_sepsis_shock:_a_prospective_clinical_study]_ L2 - https://medlineplus.gov/criticalcare.html DB - PRIME DP - Unbound Medicine ER -