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Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine.
Arch Pharm Res. 2008 Aug; 31(8):1023-8.AP

Abstract

The effects of poloxamer and HPMC on the dissolution rate of felodipine were investigated and a felodipine controlled release tablet was developed by increasing the water solubility of felodipine and using swelling polymer to control release rate. Milling of felodipine slightly increased the dissolution rate of felodipine when compared with physical mixture. XRD results indicated that felodipine remained in the crystalline form even after co-milling with poloxamer. Improved dissolution rates after co-milling with HPMC and poloxamer were due to both solubilization effect of polymer and milling. The effect of poloxamer on dissolution rate was more significant than that of HPMC. Based on increased solubility of felodipine in the presence of poloxamer, it was concluded that the improved dissolution rate of felodipine was mainly due to a high local concentration of poloxamer around felodipine. Controlled release felodipine tablets were prepared using poloxamer as a solubilizing agent and Carbopol as a controlled release matrix.

Authors+Show Affiliations

BK21 Project Team, College of Pharmacy, Chosun University, Gwangju 501-759, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18787792

Citation

Lee, Kyeo-Re, et al. "Effect of Poloxamer On the Dissolution of Felodipine and Preparation of Controlled Release Matrix Tablets Containing Felodipine." Archives of Pharmacal Research, vol. 31, no. 8, 2008, pp. 1023-8.
Lee KR, Kim EJ, Seo SW, et al. Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine. Arch Pharm Res. 2008;31(8):1023-8.
Lee, K. R., Kim, E. J., Seo, S. W., & Choi, H. K. (2008). Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine. Archives of Pharmacal Research, 31(8), 1023-8. https://doi.org/10.1007/s12272-001-1263-9
Lee KR, et al. Effect of Poloxamer On the Dissolution of Felodipine and Preparation of Controlled Release Matrix Tablets Containing Felodipine. Arch Pharm Res. 2008;31(8):1023-8. PubMed PMID: 18787792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of poloxamer on the dissolution of felodipine and preparation of controlled release matrix tablets containing felodipine. AU - Lee,Kyeo-Re, AU - Kim,Eun-Jung, AU - Seo,Sang-Wan, AU - Choi,Hoo-Kyun, Y1 - 2008/09/12/ PY - 2007/10/02/received PY - 2008/07/07/accepted PY - 2008/02/05/revised PY - 2008/9/13/pubmed PY - 2008/10/15/medline PY - 2008/9/13/entrez SP - 1023 EP - 8 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 31 IS - 8 N2 - The effects of poloxamer and HPMC on the dissolution rate of felodipine were investigated and a felodipine controlled release tablet was developed by increasing the water solubility of felodipine and using swelling polymer to control release rate. Milling of felodipine slightly increased the dissolution rate of felodipine when compared with physical mixture. XRD results indicated that felodipine remained in the crystalline form even after co-milling with poloxamer. Improved dissolution rates after co-milling with HPMC and poloxamer were due to both solubilization effect of polymer and milling. The effect of poloxamer on dissolution rate was more significant than that of HPMC. Based on increased solubility of felodipine in the presence of poloxamer, it was concluded that the improved dissolution rate of felodipine was mainly due to a high local concentration of poloxamer around felodipine. Controlled release felodipine tablets were prepared using poloxamer as a solubilizing agent and Carbopol as a controlled release matrix. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/18787792/Effect_of_poloxamer_on_the_dissolution_of_felodipine_and_preparation_of_controlled_release_matrix_tablets_containing_felodipine_ L2 - https://dx.doi.org/10.1007/s12272-001-1263-9 DB - PRIME DP - Unbound Medicine ER -