Tags

Type your tag names separated by a space and hit enter

Verbal working memory dysfunction in schizophrenia: an FMRI investigation.
Int J Neurosci. 2008 Oct; 118(10):1467-87.IJ

Abstract

Impaired processing of working memory information is one of the cognitive deficits seen in patients with schizophrenia. This study aims at corroborating the differences in the brain activities involved in the process of working memory between patients with schizophrenia and the controls. Twelve patients with schizophrenia and 11 controls participated in the study. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the performance of a two-back verbal working memory paradigm using the Korean alphabet as mnemonic content. Group analysis revealed that inferior fontal, middle frontal, and superior temporal region showed decreased cortical activities in the patient group compared to those of the controls. This study showed a decreased activation in inferior fontal (BA 47), middle frontal (BA 6), and superior temporal (BA 22/38) neural networks from the patient group and confirmed the earlier findings on the impaired working memory of schizophrenic patients in the fMRI investigation.

Authors+Show Affiliations

Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18788030

Citation

Pae, Chi-Un, et al. "Verbal Working Memory Dysfunction in Schizophrenia: an FMRI Investigation." The International Journal of Neuroscience, vol. 118, no. 10, 2008, pp. 1467-87.
Pae CU, Juh R, Yoo SS, et al. Verbal working memory dysfunction in schizophrenia: an FMRI investigation. Int J Neurosci. 2008;118(10):1467-87.
Pae, C. U., Juh, R., Yoo, S. S., Choi, B. G., Lim, H. K., Lee, C., Paik, I. H., Jeun, S. S., & Lee, C. U. (2008). Verbal working memory dysfunction in schizophrenia: an FMRI investigation. The International Journal of Neuroscience, 118(10), 1467-87. https://doi.org/10.1080/00207450701591131
Pae CU, et al. Verbal Working Memory Dysfunction in Schizophrenia: an FMRI Investigation. Int J Neurosci. 2008;118(10):1467-87. PubMed PMID: 18788030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Verbal working memory dysfunction in schizophrenia: an FMRI investigation. AU - Pae,Chi-Un, AU - Juh,Rahyeong, AU - Yoo,Seung-Schik, AU - Choi,Byung-Gil, AU - Lim,Hyun-Kook, AU - Lee,Chul, AU - Paik,In-Ho, AU - Jeun,Sin Su, AU - Lee,Chang-Uk, PY - 2008/9/13/pubmed PY - 2009/1/22/medline PY - 2008/9/13/entrez SP - 1467 EP - 87 JF - The International journal of neuroscience JO - Int. J. Neurosci. VL - 118 IS - 10 N2 - Impaired processing of working memory information is one of the cognitive deficits seen in patients with schizophrenia. This study aims at corroborating the differences in the brain activities involved in the process of working memory between patients with schizophrenia and the controls. Twelve patients with schizophrenia and 11 controls participated in the study. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the performance of a two-back verbal working memory paradigm using the Korean alphabet as mnemonic content. Group analysis revealed that inferior fontal, middle frontal, and superior temporal region showed decreased cortical activities in the patient group compared to those of the controls. This study showed a decreased activation in inferior fontal (BA 47), middle frontal (BA 6), and superior temporal (BA 22/38) neural networks from the patient group and confirmed the earlier findings on the impaired working memory of schizophrenic patients in the fMRI investigation. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/18788030/Verbal_working_memory_dysfunction_in_schizophrenia:_an_FMRI_investigation_ L2 - http://www.tandfonline.com/doi/full/10.1080/00207450701591131 DB - PRIME DP - Unbound Medicine ER -