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Changes in platelet function in Dachshunds with early stages of myxomatous mitral valve disease.
Res Vet Sci. 2009 Apr; 86(2):320-4.RV

Abstract

The aim of this study was to evaluate platelet function in Dachshunds during early stages of myxomatous mitral valve disease. Clinical examination and echocardiography were performed in 34 wirehaired standard sized Dachshunds. Platelet function was evaluated using the PFA-100 (reported as closure time). In addition, whole blood platelet aggregation response and hemostatic markers were evaluated. Significant longer PFA-100 closure time (CT) was found in 12 Dachshunds with mild mitral regurgitation (MR) compared to 22 Dachshunds with minimal MR. Only five Dachshunds responded to adenosine diphosphate in the whole blood aggregation analyses. There were no differences between the two dog groups in plasma fibrinogen, plasma von Willebrand factor (vWf) or vWf multimer distribution; however, there was a significant correlation between CT and plasma vWf concentration and CT and plasma fibrinogen concentration. The higher CT found in Dachshunds with mild MR suggests a form of platelet dysfunction in Dachshunds with MR.

Authors+Show Affiliations

Department of Basic Animal and Veterinary Sciences, University of Copenhagen, 7 Groennegaardsvej, Frederiksberg C DK-1870, Denmark. som@life.ku.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18789461

Citation

Moesgaard, S G., et al. "Changes in Platelet Function in Dachshunds With Early Stages of Myxomatous Mitral Valve Disease." Research in Veterinary Science, vol. 86, no. 2, 2009, pp. 320-4.
Moesgaard SG, Sørensen TM, Sterup A, et al. Changes in platelet function in Dachshunds with early stages of myxomatous mitral valve disease. Res Vet Sci. 2009;86(2):320-4.
Moesgaard, S. G., Sørensen, T. M., Sterup, A., Tarnow, I., Kristensen, A. T., Jensen, A. L., & Olsen, L. H. (2009). Changes in platelet function in Dachshunds with early stages of myxomatous mitral valve disease. Research in Veterinary Science, 86(2), 320-4. https://doi.org/10.1016/j.rvsc.2008.07.019
Moesgaard SG, et al. Changes in Platelet Function in Dachshunds With Early Stages of Myxomatous Mitral Valve Disease. Res Vet Sci. 2009;86(2):320-4. PubMed PMID: 18789461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in platelet function in Dachshunds with early stages of myxomatous mitral valve disease. AU - Moesgaard,S G, AU - Sørensen,T M, AU - Sterup,A, AU - Tarnow,I, AU - Kristensen,A T, AU - Jensen,A L, AU - Olsen,L H, Y1 - 2008/09/11/ PY - 2008/01/10/received PY - 2008/07/04/revised PY - 2008/07/30/accepted PY - 2008/9/16/pubmed PY - 2009/6/10/medline PY - 2008/9/16/entrez SP - 320 EP - 4 JF - Research in veterinary science JO - Res. Vet. Sci. VL - 86 IS - 2 N2 - The aim of this study was to evaluate platelet function in Dachshunds during early stages of myxomatous mitral valve disease. Clinical examination and echocardiography were performed in 34 wirehaired standard sized Dachshunds. Platelet function was evaluated using the PFA-100 (reported as closure time). In addition, whole blood platelet aggregation response and hemostatic markers were evaluated. Significant longer PFA-100 closure time (CT) was found in 12 Dachshunds with mild mitral regurgitation (MR) compared to 22 Dachshunds with minimal MR. Only five Dachshunds responded to adenosine diphosphate in the whole blood aggregation analyses. There were no differences between the two dog groups in plasma fibrinogen, plasma von Willebrand factor (vWf) or vWf multimer distribution; however, there was a significant correlation between CT and plasma vWf concentration and CT and plasma fibrinogen concentration. The higher CT found in Dachshunds with mild MR suggests a form of platelet dysfunction in Dachshunds with MR. SN - 0034-5288 UR - https://www.unboundmedicine.com/medline/citation/18789461/Changes_in_platelet_function_in_Dachshunds_with_early_stages_of_myxomatous_mitral_valve_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(08)00172-0 DB - PRIME DP - Unbound Medicine ER -