Tags

Type your tag names separated by a space and hit enter

Effect of cigarette smoking on bone mineral density in healthy Taiwanese middle-aged men.

Abstract

The effect of cigarette smoking in relation to bone mineral density (BMD) remains inconclusive, especially in middle-aged men. This cross-sectional study was conducted to examine the effect of smoking on BMD in 837 healthy Taiwanese males (532 never-smokers, 258 current smokers, 47 former smokers; aged 46-64 yr), recruited at their routine health examination. Subjects with suspected conditions affecting bone metabolism or receiving any medications affecting bone metabolism were excluded. BMD of the lumbar spine (LSBMD) and femoral neck (FNBMD) was measured with dual-energy X-ray absorptiometry. After adjustment for confounding variables (age, weight, physical activity, alcohol consumption, and caffeine intake), we found that the mean value of LSBMD was significantly (2.9%) lower in current smoker compared with never-smokers (p=0.024), but no significant difference was observed in FNBMD. No statistically significant association was observed between former smokers and never-smokers in any of the BMD sites, indicating that quitting smoking did have a positive effect on bone density. Compared with never-smokers, current heavy smokers who consumed at least 20 cigarettes/d (n=94) had 3.8% lower LSBMD (p=0.04), but no significant difference was observed in FNBMD. In the correlation analysis, the duration of smoking was negatively associated with LSBMD (r=-0.166, p=0.004), but no association was shown in FNBMD. Our results suggested that both smoking status and duration of smoking were deleterious factors on the bone density of the lumbar spine, and the effect was cumulative with duration and quantity.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu, Taiwan 300, Republic of China.

    , ,

    Source

    MeSH

    Absorptiometry, Photon
    Analysis of Variance
    Bone Density
    Cross-Sectional Studies
    Femur Neck
    Humans
    Lumbar Vertebrae
    Male
    Middle Aged
    Regression Analysis
    Risk Factors
    Smoking
    Taiwan
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18789741

    Citation

    Kuo, Chiung-Wen, et al. "Effect of Cigarette Smoking On Bone Mineral Density in Healthy Taiwanese Middle-aged Men." Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry, vol. 11, no. 4, 2008, pp. 518-24.
    Kuo CW, Chang TH, Chi WL, et al. Effect of cigarette smoking on bone mineral density in healthy Taiwanese middle-aged men. J Clin Densitom. 2008;11(4):518-24.
    Kuo, C. W., Chang, T. H., Chi, W. L., & Chu, T. C. (2008). Effect of cigarette smoking on bone mineral density in healthy Taiwanese middle-aged men. Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry, 11(4), pp. 518-24. doi:10.1016/j.jocd.2008.07.005.
    Kuo CW, et al. Effect of Cigarette Smoking On Bone Mineral Density in Healthy Taiwanese Middle-aged Men. J Clin Densitom. 2008;11(4):518-24. PubMed PMID: 18789741.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of cigarette smoking on bone mineral density in healthy Taiwanese middle-aged men. AU - Kuo,Chiung-Wen, AU - Chang,Tung-Hao, AU - Chi,Wei-Lain, AU - Chu,Tieh-Chi, Y1 - 2008/09/12/ PY - 2007/09/11/received PY - 2008/07/22/revised PY - 2008/07/25/accepted PY - 2008/9/16/pubmed PY - 2009/2/12/medline PY - 2008/9/16/entrez SP - 518 EP - 24 JF - Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry JO - J Clin Densitom VL - 11 IS - 4 N2 - The effect of cigarette smoking in relation to bone mineral density (BMD) remains inconclusive, especially in middle-aged men. This cross-sectional study was conducted to examine the effect of smoking on BMD in 837 healthy Taiwanese males (532 never-smokers, 258 current smokers, 47 former smokers; aged 46-64 yr), recruited at their routine health examination. Subjects with suspected conditions affecting bone metabolism or receiving any medications affecting bone metabolism were excluded. BMD of the lumbar spine (LSBMD) and femoral neck (FNBMD) was measured with dual-energy X-ray absorptiometry. After adjustment for confounding variables (age, weight, physical activity, alcohol consumption, and caffeine intake), we found that the mean value of LSBMD was significantly (2.9%) lower in current smoker compared with never-smokers (p=0.024), but no significant difference was observed in FNBMD. No statistically significant association was observed between former smokers and never-smokers in any of the BMD sites, indicating that quitting smoking did have a positive effect on bone density. Compared with never-smokers, current heavy smokers who consumed at least 20 cigarettes/d (n=94) had 3.8% lower LSBMD (p=0.04), but no significant difference was observed in FNBMD. In the correlation analysis, the duration of smoking was negatively associated with LSBMD (r=-0.166, p=0.004), but no association was shown in FNBMD. Our results suggested that both smoking status and duration of smoking were deleterious factors on the bone density of the lumbar spine, and the effect was cumulative with duration and quantity. SN - 1094-6950 UR - https://www.unboundmedicine.com/medline/citation/18789741/Effect_of_cigarette_smoking_on_bone_mineral_density_in_healthy_Taiwanese_middle_aged_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1094-6950(08)00214-X DB - PRIME DP - Unbound Medicine ER -