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Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway.
Eur J Pharmacol 2008; 598(1-3):37-42EJ

Abstract

Antidepressant-like activity of folic acid in forced swimming test and in the tail suspension test was demonstrated previously by our group. In this study we investigated the involvement of N-methyl-d-aspartate (NMDA) receptors and l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate pathway in its antidepressant-like effect in the forced swimming test in mice. The antidepressant-like effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with NMDA (0.1 pmol/site, i.c.v.), l-arginine (750 mg/kg, i.p., substrate for nitric oxide synthase), S-nitroso-N-acetyl-penicillamine (SNAP, 25 microg/site, i.c.v, a NO donor) or sildenafil (5 mg/kg, i.p., phosphodiesterase 5 inhibitor). The administration of 7-nitroindazole (25 and 50 mg/kg, i.p., a specific neuronal nitric oxide synthase (nNOS) inhibitor) or methylene blue (20 mg/kg, i.p., direct inhibitor of both nitric oxide synthase and soluble guanylate cyclase) in combination with a sub-effective dose of folic acid (1 nmol/site, i.c.v.) reduced the immobility time in the FST as compared with either drug alone. Together the results suggest that the antidepressant-like effect of folic acid in the forced swimming test is dependent on an inhibition of either NMDA receptors or NO and cGMP synthesis.

Authors+Show Affiliations

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, 88040-900, Florianópolis-SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18789921

Citation

Brocardo, Patrícia de Souza, et al. "Antidepressant-like Effect of Folic Acid: Involvement of NMDA Receptors and L-arginine-nitric Oxide-cyclic Guanosine Monophosphate Pathway." European Journal of Pharmacology, vol. 598, no. 1-3, 2008, pp. 37-42.
Brocardo Pde S, Budni J, Lobato KR, et al. Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. Eur J Pharmacol. 2008;598(1-3):37-42.
Brocardo, P. d. e. . S., Budni, J., Lobato, K. R., Kaster, M. P., & Rodrigues, A. L. (2008). Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. European Journal of Pharmacology, 598(1-3), pp. 37-42. doi:10.1016/j.ejphar.2008.08.033.
Brocardo Pde S, et al. Antidepressant-like Effect of Folic Acid: Involvement of NMDA Receptors and L-arginine-nitric Oxide-cyclic Guanosine Monophosphate Pathway. Eur J Pharmacol. 2008 Nov 19;598(1-3):37-42. PubMed PMID: 18789921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. AU - Brocardo,Patrícia de Souza, AU - Budni,Josiane, AU - Lobato,Kelly Ribas, AU - Kaster,Manuella Pinto, AU - Rodrigues,Ana Lúcia S, Y1 - 2008/09/03/ PY - 2007/11/17/received PY - 2008/08/10/revised PY - 2008/08/21/accepted PY - 2008/9/16/pubmed PY - 2009/1/10/medline PY - 2008/9/16/entrez SP - 37 EP - 42 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 598 IS - 1-3 N2 - Antidepressant-like activity of folic acid in forced swimming test and in the tail suspension test was demonstrated previously by our group. In this study we investigated the involvement of N-methyl-d-aspartate (NMDA) receptors and l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate pathway in its antidepressant-like effect in the forced swimming test in mice. The antidepressant-like effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with NMDA (0.1 pmol/site, i.c.v.), l-arginine (750 mg/kg, i.p., substrate for nitric oxide synthase), S-nitroso-N-acetyl-penicillamine (SNAP, 25 microg/site, i.c.v, a NO donor) or sildenafil (5 mg/kg, i.p., phosphodiesterase 5 inhibitor). The administration of 7-nitroindazole (25 and 50 mg/kg, i.p., a specific neuronal nitric oxide synthase (nNOS) inhibitor) or methylene blue (20 mg/kg, i.p., direct inhibitor of both nitric oxide synthase and soluble guanylate cyclase) in combination with a sub-effective dose of folic acid (1 nmol/site, i.c.v.) reduced the immobility time in the FST as compared with either drug alone. Together the results suggest that the antidepressant-like effect of folic acid in the forced swimming test is dependent on an inhibition of either NMDA receptors or NO and cGMP synthesis. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/18789921/Antidepressant_like_effect_of_folic_acid:_Involvement_of_NMDA_receptors_and_L_arginine_nitric_oxide_cyclic_guanosine_monophosphate_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(08)00921-7 DB - PRIME DP - Unbound Medicine ER -