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Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy.
Clin Exp Med. 2008 Sep; 8(3):159-64.CE

Abstract

BACKGROUND

Interaction between cells via intimate cell-cell contact is facilitated by a cell surface molecules, termed adhesion molecules. The aim of the study was to evaluate the blood serum concentration of soluble forms of vascular cell adhesion molecule (VCAM-1), intercellular adhesion molecule (ICAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1) in patients with type 1 diabetes mellitus without and with diabetic retinopathy.

MATERIALS AND METHODS

The study was performed in 75 patients with type 1 diabetes mellitus, 35 without retinopathy (group 1) and 40 with retinopathy (group 2). Soluble forms of VCAM-1, ICAM-1 and ELAM-1 were determined by enzyme-linked immunosorbent assay (ELISA).

RESULTS

The serum concentration of sICAM-1 and sELAM-1 were significantly elevated and the concentration sVCAM-1 was elevated but not significantly in diabetic patients when compared with control subjects. There was a significant difference in VCAM-1 concentrations between the control group and group 2 (965.9 +/- 229.0 vs. 1283.7 +/- 387.6 ng/ml, p < 0.05) and between group 1 and group 2 (1115.0 +/- 285.5 vs. 1283.7 +/- 387.6 ng/ml, p < 0.05). There were significant differences in sICAM-1 concentrations between the control group and group 1 (p < 0.05) and between the control group and group 2 (p < 0.05). Where was no significant difference in sICAM-1 concentration between group 1 and 2 (405.2 +/- 135.9 vs. 443.1 +/- 112.7 ng/ml, p = 0.08). ELAM-1 concentration was significantly elevated in group 2 (120.5 +/- 49.3 ng/ml) when compared with the control group (51.7 +/- 18.1 ng/ml, p < 0.005) and with group 1 (81.2 +/- 27.7 ng/ml, p < 0.05).

CONCLUSIONS

The correlations found between sVCAM-1, sICAM-1 and sELAM-1 and the presence of retinopathy suggest that cellular adhesion and neovascularization may be linked processes.

Authors+Show Affiliations

Pathophysiology Division, Department of Pathophysiology and Endocrinology, Medical University of Silesia, 41-800 Zabrze pl., Traugutta 2, Poland. nowak-mar@wp.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18791689

Citation

Nowak, Mariusz, et al. "Blood Serum Levels of Vascular Cell Adhesion Molecule (sVCAM-1), Intercellular Adhesion Molecule (sICAM-1) and Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1) in Diabetic Retinopathy." Clinical and Experimental Medicine, vol. 8, no. 3, 2008, pp. 159-64.
Nowak M, Wielkoszyński T, Marek B, et al. Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Clin Exp Med. 2008;8(3):159-64.
Nowak, M., Wielkoszyński, T., Marek, B., Kos-Kudła, B., Swietochowska, E., Siemińska, L., Kajdaniuk, D., Głogowska-Szelag, J., & Nowak, K. (2008). Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Clinical and Experimental Medicine, 8(3), 159-64. https://doi.org/10.1007/s10238-008-0173-z
Nowak M, et al. Blood Serum Levels of Vascular Cell Adhesion Molecule (sVCAM-1), Intercellular Adhesion Molecule (sICAM-1) and Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1) in Diabetic Retinopathy. Clin Exp Med. 2008;8(3):159-64. PubMed PMID: 18791689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. AU - Nowak,Mariusz, AU - Wielkoszyński,Tomasz, AU - Marek,Bogdan, AU - Kos-Kudła,Beata, AU - Swietochowska,Elzbieta, AU - Siemińska,Lucyna, AU - Kajdaniuk,Dariusz, AU - Głogowska-Szelag,Joanna, AU - Nowak,Katarzyna, Y1 - 2008/09/13/ PY - 2007/10/15/received PY - 2008/04/16/accepted PY - 2008/9/16/pubmed PY - 2008/11/5/medline PY - 2008/9/16/entrez SP - 159 EP - 64 JF - Clinical and experimental medicine JO - Clin. Exp. Med. VL - 8 IS - 3 N2 - BACKGROUND: Interaction between cells via intimate cell-cell contact is facilitated by a cell surface molecules, termed adhesion molecules. The aim of the study was to evaluate the blood serum concentration of soluble forms of vascular cell adhesion molecule (VCAM-1), intercellular adhesion molecule (ICAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1) in patients with type 1 diabetes mellitus without and with diabetic retinopathy. MATERIALS AND METHODS: The study was performed in 75 patients with type 1 diabetes mellitus, 35 without retinopathy (group 1) and 40 with retinopathy (group 2). Soluble forms of VCAM-1, ICAM-1 and ELAM-1 were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: The serum concentration of sICAM-1 and sELAM-1 were significantly elevated and the concentration sVCAM-1 was elevated but not significantly in diabetic patients when compared with control subjects. There was a significant difference in VCAM-1 concentrations between the control group and group 2 (965.9 +/- 229.0 vs. 1283.7 +/- 387.6 ng/ml, p < 0.05) and between group 1 and group 2 (1115.0 +/- 285.5 vs. 1283.7 +/- 387.6 ng/ml, p < 0.05). There were significant differences in sICAM-1 concentrations between the control group and group 1 (p < 0.05) and between the control group and group 2 (p < 0.05). Where was no significant difference in sICAM-1 concentration between group 1 and 2 (405.2 +/- 135.9 vs. 443.1 +/- 112.7 ng/ml, p = 0.08). ELAM-1 concentration was significantly elevated in group 2 (120.5 +/- 49.3 ng/ml) when compared with the control group (51.7 +/- 18.1 ng/ml, p < 0.005) and with group 1 (81.2 +/- 27.7 ng/ml, p < 0.05). CONCLUSIONS: The correlations found between sVCAM-1, sICAM-1 and sELAM-1 and the presence of retinopathy suggest that cellular adhesion and neovascularization may be linked processes. SN - 1591-8890 UR - https://www.unboundmedicine.com/medline/citation/18791689/Blood_serum_levels_of_vascular_cell_adhesion_molecule__sVCAM_1__intercellular_adhesion_molecule__sICAM_1__and_endothelial_leucocyte_adhesion_molecule_1__ELAM_1__in_diabetic_retinopathy_ L2 - https://dx.doi.org/10.1007/s10238-008-0173-z DB - PRIME DP - Unbound Medicine ER -