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Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study.
Nutr Cancer 2008; 60(5):568-76NC

Abstract

Soy food and its constituents may protect against breast cancer, but the association between soy intake and decreased breast cancer risk is inconsistent. We evaluated the relationship between breast cancer risk and the dietary intake of soy protein as measured by total soy food and tofu intake. Histologically confirmed cases (n = 362) were matched to controls by age (within 2 yr) and menopausal status. High soy protein intake was associated with reduced breast cancer risk in analyses adjusted for potential confounders including dietary factors among premenopausal women (odds ratio [OR] = 0.39 in the highest quintile, 95% confidence interval [CI] = 0.22-0.93, P for trend = 0.03) and postmenopausal women (OR = 0.22, 95% CI = 0.06-0.88, P for trend = 0.16). We also found an inverse association between total tofu intake and breast cancer risk among premenopausal women (for total tofu intake, OR = 0.23 in the highest quintile, 95% CI = 0.11-0.48, P for trend < 0.01; for at least 1 serving of tofu as the main ingredient per day, OR = 0.26, 95% CI = 0.13-0.55, P for trend < 0.01). We concluded that increased regular soy food intake at a level equivalent to traditional Korean consumption levels may be associated with a reduced risk of breast cancer, and this effect is more pronounced in premenopausal women.

Authors+Show Affiliations

Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea. kmkkim@hanyang.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18791919

Citation

Kim, Mi Kyung, et al. "Dietary Intake of Soy Protein and Tofu in Association With Breast Cancer Risk Based On a Case-control Study." Nutrition and Cancer, vol. 60, no. 5, 2008, pp. 568-76.
Kim MK, Kim JH, Nam SJ, et al. Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. Nutr Cancer. 2008;60(5):568-76.
Kim, M. K., Kim, J. H., Nam, S. J., Ryu, S., & Kong, G. (2008). Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. Nutrition and Cancer, 60(5), pp. 568-76. doi:10.1080/01635580801966203.
Kim MK, et al. Dietary Intake of Soy Protein and Tofu in Association With Breast Cancer Risk Based On a Case-control Study. Nutr Cancer. 2008;60(5):568-76. PubMed PMID: 18791919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. AU - Kim,Mi Kyung, AU - Kim,Jin Hee, AU - Nam,Seok Jin, AU - Ryu,Seungho, AU - Kong,Gu, PY - 2008/9/16/pubmed PY - 2009/2/20/medline PY - 2008/9/16/entrez SP - 568 EP - 76 JF - Nutrition and cancer JO - Nutr Cancer VL - 60 IS - 5 N2 - Soy food and its constituents may protect against breast cancer, but the association between soy intake and decreased breast cancer risk is inconsistent. We evaluated the relationship between breast cancer risk and the dietary intake of soy protein as measured by total soy food and tofu intake. Histologically confirmed cases (n = 362) were matched to controls by age (within 2 yr) and menopausal status. High soy protein intake was associated with reduced breast cancer risk in analyses adjusted for potential confounders including dietary factors among premenopausal women (odds ratio [OR] = 0.39 in the highest quintile, 95% confidence interval [CI] = 0.22-0.93, P for trend = 0.03) and postmenopausal women (OR = 0.22, 95% CI = 0.06-0.88, P for trend = 0.16). We also found an inverse association between total tofu intake and breast cancer risk among premenopausal women (for total tofu intake, OR = 0.23 in the highest quintile, 95% CI = 0.11-0.48, P for trend < 0.01; for at least 1 serving of tofu as the main ingredient per day, OR = 0.26, 95% CI = 0.13-0.55, P for trend < 0.01). We concluded that increased regular soy food intake at a level equivalent to traditional Korean consumption levels may be associated with a reduced risk of breast cancer, and this effect is more pronounced in premenopausal women. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/18791919/Dietary_intake_of_soy_protein_and_tofu_in_association_with_breast_cancer_risk_based_on_a_case_control_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580801966203 DB - PRIME DP - Unbound Medicine ER -