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The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair.
J Cell Physiol. 2009 Feb; 218(2):237-45.JC

Abstract

Four decades after the first isolation and characterization of clonogenic bone marrow stromal cells or mesenchymal stem cells (MSC) in the laboratory of Dr. Alexander Friedenstien, the therapeutic application of their progeny following ex vivo expansion are only now starting to be realized in the clinic. The multipotency, paracrine effects, and immune-modulatory properties of MSC present them as an ideal stem cell candidate for tissue engineering and regenerative medicine. In recent years it has come to light that MSC encompass plasticity that extends beyond the conventional bone, adipose, cartilage, and other skeletal structures, and has expanded to the differentiation of liver, kidney, muscle, skin, neural, and cardiac cell lineages. This review will specifically focus on the skeletal regenerative capacity of bone marrow derived MSC alone or in combination with growth factors, biocompatible scaffolds, and following genetic modification.

Authors+Show Affiliations

Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute/University of Adelaide, Adelaide, South Australia, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18792913

Citation

Arthur, Agnieszka, et al. "The Therapeutic Applications of Multipotential Mesenchymal/stromal Stem Cells in Skeletal Tissue Repair." Journal of Cellular Physiology, vol. 218, no. 2, 2009, pp. 237-45.
Arthur A, Zannettino A, Gronthos S. The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. J Cell Physiol. 2009;218(2):237-45.
Arthur, A., Zannettino, A., & Gronthos, S. (2009). The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. Journal of Cellular Physiology, 218(2), 237-45. https://doi.org/10.1002/jcp.21592
Arthur A, Zannettino A, Gronthos S. The Therapeutic Applications of Multipotential Mesenchymal/stromal Stem Cells in Skeletal Tissue Repair. J Cell Physiol. 2009;218(2):237-45. PubMed PMID: 18792913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. AU - Arthur,Agnieszka, AU - Zannettino,Andrew, AU - Gronthos,Stan, PY - 2008/9/17/pubmed PY - 2008/12/18/medline PY - 2008/9/17/entrez SP - 237 EP - 45 JF - Journal of cellular physiology JO - J. Cell. Physiol. VL - 218 IS - 2 N2 - Four decades after the first isolation and characterization of clonogenic bone marrow stromal cells or mesenchymal stem cells (MSC) in the laboratory of Dr. Alexander Friedenstien, the therapeutic application of their progeny following ex vivo expansion are only now starting to be realized in the clinic. The multipotency, paracrine effects, and immune-modulatory properties of MSC present them as an ideal stem cell candidate for tissue engineering and regenerative medicine. In recent years it has come to light that MSC encompass plasticity that extends beyond the conventional bone, adipose, cartilage, and other skeletal structures, and has expanded to the differentiation of liver, kidney, muscle, skin, neural, and cardiac cell lineages. This review will specifically focus on the skeletal regenerative capacity of bone marrow derived MSC alone or in combination with growth factors, biocompatible scaffolds, and following genetic modification. SN - 1097-4652 UR - https://www.unboundmedicine.com/medline/citation/18792913/The_therapeutic_applications_of_multipotential_mesenchymal/stromal_stem_cells_in_skeletal_tissue_repair_ L2 - https://doi.org/10.1002/jcp.21592 DB - PRIME DP - Unbound Medicine ER -