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Gastrointestinal symptoms and glycemic control in diabetes mellitus: a longitudinal population study.
Eur J Gastroenterol Hepatol. 2008 Sep; 20(9):888-97.EJ

Abstract

BACKGROUND

The prevalence of gastrointestinal (GI) symptoms is increased in diabetes, but their natural history is understood poorly and any impact of glycemic control is controversial. We aimed to quantify changes in GI symptom status and glycemic control among a population sample of patients with diabetes.

METHODS

Data on 10 chronic GI symptom complexes were obtained from a validated questionnaire at baseline and after 12 months. Changes in acute and chronic glycemic control were classified as always adequate, variable (deteriorated or improved), or always inadequate; acute glycemic control was assessed by fasting plasma glucose and chronic glycemic control by a validated self-report 5-point graded scale.

RESULTS

Baseline and follow-up data were available in 136 individuals with diabetes (mean age 59 years; 66% males; 95% type 2). The most prevalent GI symptom complexes were abdominal bloating/distension (35%), ulcer-like dyspepsia (35%), and irritable bowel syndrome (27%). Overall, between 7 and 24% reported a change in GI symptoms with the largest change in irritable bowel syndrome (24%), bloating/distension (22%), and ulcer-like dyspepsia (21%). Those who had a change in abdominal bloating (either loss or gain) over 12 months were more likely to have increased their mean fasting plasma glucose (P<0.05). Contrary to expectations, consistently poor self-reported glycemic control was only weakly associated with less persistent abdominal pain (r=-0.2, P=0.03), diarrhea (r=-0.22, P=0.01), and abdominal bloating (r=-0.2, P=0.03). Acute glycemic control was not significantly related to any GI symptoms.

CONCLUSION

We were unable to demonstrate any association between worsening GI symptoms and glycemic control.

Authors+Show Affiliations

Department of Medicine, Nepean Hospital, University of Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18794603

Citation

Quan, Carolyn, et al. "Gastrointestinal Symptoms and Glycemic Control in Diabetes Mellitus: a Longitudinal Population Study." European Journal of Gastroenterology & Hepatology, vol. 20, no. 9, 2008, pp. 888-97.
Quan C, Talley NJ, Jones MP, et al. Gastrointestinal symptoms and glycemic control in diabetes mellitus: a longitudinal population study. Eur J Gastroenterol Hepatol. 2008;20(9):888-97.
Quan, C., Talley, N. J., Jones, M. P., Howell, S., & Horowitz, M. (2008). Gastrointestinal symptoms and glycemic control in diabetes mellitus: a longitudinal population study. European Journal of Gastroenterology & Hepatology, 20(9), 888-97. https://doi.org/10.1097/MEG.0b013e3282f5f734
Quan C, et al. Gastrointestinal Symptoms and Glycemic Control in Diabetes Mellitus: a Longitudinal Population Study. Eur J Gastroenterol Hepatol. 2008;20(9):888-97. PubMed PMID: 18794603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal symptoms and glycemic control in diabetes mellitus: a longitudinal population study. AU - Quan,Carolyn, AU - Talley,Nicholas J, AU - Jones,Michael P, AU - Howell,Stuart, AU - Horowitz,Michael, PY - 2008/9/17/pubmed PY - 2008/12/30/medline PY - 2008/9/17/entrez SP - 888 EP - 97 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 20 IS - 9 N2 - BACKGROUND: The prevalence of gastrointestinal (GI) symptoms is increased in diabetes, but their natural history is understood poorly and any impact of glycemic control is controversial. We aimed to quantify changes in GI symptom status and glycemic control among a population sample of patients with diabetes. METHODS: Data on 10 chronic GI symptom complexes were obtained from a validated questionnaire at baseline and after 12 months. Changes in acute and chronic glycemic control were classified as always adequate, variable (deteriorated or improved), or always inadequate; acute glycemic control was assessed by fasting plasma glucose and chronic glycemic control by a validated self-report 5-point graded scale. RESULTS: Baseline and follow-up data were available in 136 individuals with diabetes (mean age 59 years; 66% males; 95% type 2). The most prevalent GI symptom complexes were abdominal bloating/distension (35%), ulcer-like dyspepsia (35%), and irritable bowel syndrome (27%). Overall, between 7 and 24% reported a change in GI symptoms with the largest change in irritable bowel syndrome (24%), bloating/distension (22%), and ulcer-like dyspepsia (21%). Those who had a change in abdominal bloating (either loss or gain) over 12 months were more likely to have increased their mean fasting plasma glucose (P<0.05). Contrary to expectations, consistently poor self-reported glycemic control was only weakly associated with less persistent abdominal pain (r=-0.2, P=0.03), diarrhea (r=-0.22, P=0.01), and abdominal bloating (r=-0.2, P=0.03). Acute glycemic control was not significantly related to any GI symptoms. CONCLUSION: We were unable to demonstrate any association between worsening GI symptoms and glycemic control. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/18794603/Gastrointestinal_symptoms_and_glycemic_control_in_diabetes_mellitus:_a_longitudinal_population_study_ L2 - https://doi.org/10.1097/MEG.0b013e3282f5f734 DB - PRIME DP - Unbound Medicine ER -