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Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis.
Clin Rheumatol 2008; 27(12):1557-63CR

Abstract

Conflicting evidence for the effect of moderate alcohol drinking on the development of systemic lupus erythematosus (SLE) existed at present. In the current study, we performed an extensive search of relevant studies and performed a meta-analysis to obtain a more precise estimate. Thirty-eight studies were identified from electronic databases and chosen for detailed review, then six articles from six case-control studies with one cohort study were included in our meta-analyses. Meta-analyses were divided into two subgroups in which patients in the study of Washio et al. treated for less than 5 years (subgroup A) or less than 10 years (subgroup B) were involved, respectively. The odds ratio (OR) of moderate alcohol drinking in the meta-analyses of subgroup B for the development of SLE was significantly decreased (OR 0.723, 95% confidence interval (95% CI) 0.547-0.954), while moderate alcohol drinking in the meta-analysis of subgroup A did not demonstrate a decreased risk of SLE (OR 0.780, 95% CI 0.491-1.240). Meta-analyses of six case-control studies in the two subgroups both demonstrated that moderate alcohol drinking had a protective effect on the development of SLE. Taken together, our results show that moderate alcohol drinking might be protective for SLE.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

18795396

Citation

Wang, Jing, et al. "Moderate Alcohol Drinking Might Be Protective for Systemic Lupus Erythematosus: a Systematic Review and Meta-analysis." Clinical Rheumatology, vol. 27, no. 12, 2008, pp. 1557-63.
Wang J, Pan HF, Ye DQ, et al. Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis. Clin Rheumatol. 2008;27(12):1557-63.
Wang, J., Pan, H. F., Ye, D. Q., Su, H., & Li, X. P. (2008). Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis. Clinical Rheumatology, 27(12), pp. 1557-63. doi:10.1007/s10067-008-1004-z.
Wang J, et al. Moderate Alcohol Drinking Might Be Protective for Systemic Lupus Erythematosus: a Systematic Review and Meta-analysis. Clin Rheumatol. 2008;27(12):1557-63. PubMed PMID: 18795396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis. AU - Wang,Jing, AU - Pan,Hai-Feng, AU - Ye,Dong-Qing, AU - Su,Hong, AU - Li,Xiang-Pei, Y1 - 2008/09/16/ PY - 2008/06/25/received PY - 2008/08/27/accepted PY - 2008/08/26/revised PY - 2008/9/17/pubmed PY - 2009/4/14/medline PY - 2008/9/17/entrez SP - 1557 EP - 63 JF - Clinical rheumatology JO - Clin. Rheumatol. VL - 27 IS - 12 N2 - Conflicting evidence for the effect of moderate alcohol drinking on the development of systemic lupus erythematosus (SLE) existed at present. In the current study, we performed an extensive search of relevant studies and performed a meta-analysis to obtain a more precise estimate. Thirty-eight studies were identified from electronic databases and chosen for detailed review, then six articles from six case-control studies with one cohort study were included in our meta-analyses. Meta-analyses were divided into two subgroups in which patients in the study of Washio et al. treated for less than 5 years (subgroup A) or less than 10 years (subgroup B) were involved, respectively. The odds ratio (OR) of moderate alcohol drinking in the meta-analyses of subgroup B for the development of SLE was significantly decreased (OR 0.723, 95% confidence interval (95% CI) 0.547-0.954), while moderate alcohol drinking in the meta-analysis of subgroup A did not demonstrate a decreased risk of SLE (OR 0.780, 95% CI 0.491-1.240). Meta-analyses of six case-control studies in the two subgroups both demonstrated that moderate alcohol drinking had a protective effect on the development of SLE. Taken together, our results show that moderate alcohol drinking might be protective for SLE. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/18795396/full_citation L2 - https://dx.doi.org/10.1007/s10067-008-1004-z DB - PRIME DP - Unbound Medicine ER -