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Lack of association of delta-aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations.
Acta Paediatr 2008; 97(12):1717-20AP

Abstract

AIM

A cross-section study was conducted to explore the association between polymorphism of delta-aminolevulinic acid dehydratase (ALAD) and lead poisoning in Uygur and Han children in China.

METHODS

The ALAD genotyping was determined by PCR-RFLP in 443 Uygur and 469 Han children aged 6-10 years from Urumqi in Xinjiang province.

RESULTS

The blood lead levels of 912 environmentally exposed children ranged from 0.5 to 48.2 microg/dL, with a mean of 5.45 microg/dL and a standard deviation of 0.22 microg/dL, and 23. Thirty-one percent individuals were with blood lead level > or =10 microg/dL. The mean and standard deviation of blood lead levels were 5.57 +/- 0.223 microg/dL and 5.30 +/- 0.224 microg/dL in Uygur and Han children, respectively. The frequencies of the allele ALAD1 and ALAD2 in Uygur subjects were 90.52% and 9.48%, and in Han subjects were 95.73% and 4.27%, respectively (chi-square = 19.55, p < 0.05). No statistic correlation between the distribution of ALAD alleles and the blood lead level was found in both populations.

CONCLUSION

A significant difference was seen in the frequency distribution of ALAD genotype between the different races. The genetic susceptibility of ALAD polymorphism to lead toxicity may exhibit in a lead dose-dependent manner.

Authors+Show Affiliations

Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China. ychen88@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18795909

Citation

Chen, Yan, et al. "Lack of Association of Delta-aminolevulinic Acid Dehydratase Genotype With Blood Lead Levels in Environmentally Exposed Children of Uygur and Han Populations." Acta Paediatrica (Oslo, Norway : 1992), vol. 97, no. 12, 2008, pp. 1717-20.
Chen Y, Zhao JX, Liu JW, et al. Lack of association of delta-aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations. Acta Paediatr. 2008;97(12):1717-20.
Chen, Y., Zhao, J. X., Liu, J. W., Cui, J., Li, L., & Tian, W. (2008). Lack of association of delta-aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations. Acta Paediatrica (Oslo, Norway : 1992), 97(12), pp. 1717-20. doi:10.1111/j.1651-2227.2008.01003.x.
Chen Y, et al. Lack of Association of Delta-aminolevulinic Acid Dehydratase Genotype With Blood Lead Levels in Environmentally Exposed Children of Uygur and Han Populations. Acta Paediatr. 2008;97(12):1717-20. PubMed PMID: 18795909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association of delta-aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations. AU - Chen,Yan, AU - Zhao,Jiang-Xia, AU - Liu,Ji-Wen, AU - Cui,Jun, AU - Li,Ling, AU - Tian,Wei, Y1 - 2008/09/15/ PY - 2008/9/18/pubmed PY - 2009/2/21/medline PY - 2008/9/18/entrez SP - 1717 EP - 20 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 97 IS - 12 N2 - AIM: A cross-section study was conducted to explore the association between polymorphism of delta-aminolevulinic acid dehydratase (ALAD) and lead poisoning in Uygur and Han children in China. METHODS: The ALAD genotyping was determined by PCR-RFLP in 443 Uygur and 469 Han children aged 6-10 years from Urumqi in Xinjiang province. RESULTS: The blood lead levels of 912 environmentally exposed children ranged from 0.5 to 48.2 microg/dL, with a mean of 5.45 microg/dL and a standard deviation of 0.22 microg/dL, and 23. Thirty-one percent individuals were with blood lead level > or =10 microg/dL. The mean and standard deviation of blood lead levels were 5.57 +/- 0.223 microg/dL and 5.30 +/- 0.224 microg/dL in Uygur and Han children, respectively. The frequencies of the allele ALAD1 and ALAD2 in Uygur subjects were 90.52% and 9.48%, and in Han subjects were 95.73% and 4.27%, respectively (chi-square = 19.55, p < 0.05). No statistic correlation between the distribution of ALAD alleles and the blood lead level was found in both populations. CONCLUSION: A significant difference was seen in the frequency distribution of ALAD genotype between the different races. The genetic susceptibility of ALAD polymorphism to lead toxicity may exhibit in a lead dose-dependent manner. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/18795909/Lack_of_association_of_delta_aminolevulinic_acid_dehydratase_genotype_with_blood_lead_levels_in_environmentally_exposed_children_of_Uygur_and_Han_populations_ L2 - https://doi.org/10.1111/j.1651-2227.2008.01003.x DB - PRIME DP - Unbound Medicine ER -