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The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders.
Am J Gastroenterol. 2008 Aug; 103(8):1989-97.AJ

Abstract

BACKGROUND AND AIMS

Given the impact of anxiety and mood disorders on health, it is important to consider these disorders in persons with inflammatory bowel disease (IBD). We assessed the prevalence of anxiety and mood disorders in a population-based IBD cohort.

METHODS

A structured diagnostic interview was administered to participants in the cohort (N = 351), and rates were compared to age-, gender-, and region-matched controls drawn from a national survey (N = 779).

RESULTS

A comparison of lifetime prevalence suggests higher rates of panic, generalized anxiety, and obsessive-compulsive disorders and major depression and lower rates of social anxiety and bipolar disorders in the IBD sample than in national samples in the United States and New Zealand. Direct comparisons with matched controls (with data available for three anxiety disorders) found lifetime prevalence (IBD vs controls) as follows: social anxiety disorder lower in IBD (6%vs 11%, OR 0.52, 95% CI 0.32-0.85), panic disorder not significantly different (8.0%vs 4.7%, OR 1.59, 95% CI 0.96-2.63), agoraphobia without panic not significantly different (1.1%vs 0.6%, OR 1.44, 95% CI 0.37-5.55), and major depression higher (27.2%vs 12.3%, OR 2.20, 95% CI 1.64-2.95). Comparing IBD respondents with and without lifetime anxiety or mood disorder, those with a disorder reported lower quality of life and earlier onset of IBD symptoms and there was a trend toward earlier IBD diagnosis.

CONCLUSIONS

Clinicians should be aware of the increased prevalence of depression and possibly other anxiety disorders in persons with IBD as these disorders may influence response to treatment and quality of life.

Authors+Show Affiliations

University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Manitoba, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18796096

Citation

Walker, John R., et al. "The Manitoba IBD Cohort Study: a Population-based Study of the Prevalence of Lifetime and 12-month Anxiety and Mood Disorders." The American Journal of Gastroenterology, vol. 103, no. 8, 2008, pp. 1989-97.
Walker JR, Ediger JP, Graff LA, et al. The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders. Am J Gastroenterol. 2008;103(8):1989-97.
Walker, J. R., Ediger, J. P., Graff, L. A., Greenfeld, J. M., Clara, I., Lix, L., Rawsthorne, P., Miller, N., Rogala, L., McPhail, C. M., & Bernstein, C. N. (2008). The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders. The American Journal of Gastroenterology, 103(8), 1989-97. https://doi.org/10.1111/j.1572-0241.2008.01980.x
Walker JR, et al. The Manitoba IBD Cohort Study: a Population-based Study of the Prevalence of Lifetime and 12-month Anxiety and Mood Disorders. Am J Gastroenterol. 2008;103(8):1989-97. PubMed PMID: 18796096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders. AU - Walker,John R, AU - Ediger,Jason P, AU - Graff,Lesley A, AU - Greenfeld,Jay M, AU - Clara,Ian, AU - Lix,Lisa, AU - Rawsthorne,Patricia, AU - Miller,Norine, AU - Rogala,Linda, AU - McPhail,Cory M, AU - Bernstein,Charles N, PY - 2008/9/18/pubmed PY - 2008/10/22/medline PY - 2008/9/18/entrez SP - 1989 EP - 97 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 103 IS - 8 N2 - BACKGROUND AND AIMS: Given the impact of anxiety and mood disorders on health, it is important to consider these disorders in persons with inflammatory bowel disease (IBD). We assessed the prevalence of anxiety and mood disorders in a population-based IBD cohort. METHODS: A structured diagnostic interview was administered to participants in the cohort (N = 351), and rates were compared to age-, gender-, and region-matched controls drawn from a national survey (N = 779). RESULTS: A comparison of lifetime prevalence suggests higher rates of panic, generalized anxiety, and obsessive-compulsive disorders and major depression and lower rates of social anxiety and bipolar disorders in the IBD sample than in national samples in the United States and New Zealand. Direct comparisons with matched controls (with data available for three anxiety disorders) found lifetime prevalence (IBD vs controls) as follows: social anxiety disorder lower in IBD (6%vs 11%, OR 0.52, 95% CI 0.32-0.85), panic disorder not significantly different (8.0%vs 4.7%, OR 1.59, 95% CI 0.96-2.63), agoraphobia without panic not significantly different (1.1%vs 0.6%, OR 1.44, 95% CI 0.37-5.55), and major depression higher (27.2%vs 12.3%, OR 2.20, 95% CI 1.64-2.95). Comparing IBD respondents with and without lifetime anxiety or mood disorder, those with a disorder reported lower quality of life and earlier onset of IBD symptoms and there was a trend toward earlier IBD diagnosis. CONCLUSIONS: Clinicians should be aware of the increased prevalence of depression and possibly other anxiety disorders in persons with IBD as these disorders may influence response to treatment and quality of life. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/18796096/The_Manitoba_IBD_cohort_study:_a_population_based_study_of_the_prevalence_of_lifetime_and_12_month_anxiety_and_mood_disorders_ L2 - http://Insights.ovid.com/pubmed?pmid=18796096 DB - PRIME DP - Unbound Medicine ER -