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Weakness on the intensive care unit.
Pract Neurol. 2008 Oct; 8(5):280-95.PN

Abstract

Patients who are recovering from critical illness may be weak and difficult to wean from ventilatory support as a complication of their underlying disorder, intercurrent events or treatment given during prolonged intensive care. These patients are difficult to assess because of the severity of their weakness and any accompanying encephalopathy. It is essential to undertake a meticulous review, including assessment of any septic, hypoxic or metabolic derangements and a detailed look at the dosage and duration of medication including antibiotics, neuromuscular junction blocking agents and sedation. If a primary underlying neurological cause or an intercurrent event have been excluded, the likeliest cause of weakness is one of the neuromuscular complications of critical care such as: critical care polyneuropathy, an acute axonal neuropathy which develops in patients with preceding sepsis or multi-organ failure; the use of neuromuscular junction blocking agents or steroids; and critical illness myopathy, which is the most common cause of critical care related weakness.

Authors+Show Affiliations

National Hospital for Neurology and Neurosurgery, London, UK. robin.howard@uclh.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18796583

Citation

Howard, R S., et al. "Weakness On the Intensive Care Unit." Practical Neurology, vol. 8, no. 5, 2008, pp. 280-95.
Howard RS, Tan SV, Z'Graggen WJ. Weakness on the intensive care unit. Pract Neurol. 2008;8(5):280-95.
Howard, R. S., Tan, S. V., & Z'Graggen, W. J. (2008). Weakness on the intensive care unit. Practical Neurology, 8(5), 280-95. https://doi.org/10.1136/jnnp.2008.157263
Howard RS, Tan SV, Z'Graggen WJ. Weakness On the Intensive Care Unit. Pract Neurol. 2008;8(5):280-95. PubMed PMID: 18796583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weakness on the intensive care unit. AU - Howard,R S, AU - Tan,S V, AU - Z'Graggen,W J, PY - 2008/9/18/pubmed PY - 2008/12/17/medline PY - 2008/9/18/entrez SP - 280 EP - 95 JF - Practical neurology JO - Pract Neurol VL - 8 IS - 5 N2 - Patients who are recovering from critical illness may be weak and difficult to wean from ventilatory support as a complication of their underlying disorder, intercurrent events or treatment given during prolonged intensive care. These patients are difficult to assess because of the severity of their weakness and any accompanying encephalopathy. It is essential to undertake a meticulous review, including assessment of any septic, hypoxic or metabolic derangements and a detailed look at the dosage and duration of medication including antibiotics, neuromuscular junction blocking agents and sedation. If a primary underlying neurological cause or an intercurrent event have been excluded, the likeliest cause of weakness is one of the neuromuscular complications of critical care such as: critical care polyneuropathy, an acute axonal neuropathy which develops in patients with preceding sepsis or multi-organ failure; the use of neuromuscular junction blocking agents or steroids; and critical illness myopathy, which is the most common cause of critical care related weakness. SN - 1474-7766 UR - https://www.unboundmedicine.com/medline/citation/18796583/Weakness_on_the_intensive_care_unit_ DB - PRIME DP - Unbound Medicine ER -