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Structure, biology, evolution, and medical importance of sulfated fucans and galactans.
Glycobiology. 2008 Dec; 18(12):1016-27.G

Abstract

Sulfated fucans and galactans are strongly anionic polysaccharides found in marine organisms. Their structures vary among species, but their major features are conserved among phyla. Sulfated fucans are found in marine brown algae and echinoderms, whereas sulfated galactans occur in red and green algae, marine angiosperms, tunicates (ascidians), and sea urchins. Polysaccharides with 3-linked, beta-galactose units are highly conserved in some taxonomic groups of marine organisms and show a strong tendency toward 4-sulfation in algae and marine angiosperms, and 2-sulfation in invertebrates. Marine algae mainly express sulfated polysaccharides with complex, heterogeneous structures, whereas marine invertebrates synthesize sulfated fucans and sulfated galactans with regular repetitive structures. These polysaccharides are structural components of the extracellular matrix. Sulfated fucans and galactans are involved in sea urchin fertilization acting as species-specific inducers of the sperm acrosome reaction. Because of this function the structural evolution of sulfated fucans could be a component in the speciation process. The algal and invertebrate polysaccharides are also potent anticoagulant agents of mammalian blood and represent a potential source of compounds for antithrombotic therapies.

Authors+Show Affiliations

Hospital Universitário Clementino Fraga Filho and Programa de Glicobiologia, Instituto de Bioquímica Médica, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Caixa Postal 68041, Rio de Janeiro, RJ 21941-590, Brazil. vhpomin@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18796647

Citation

Pomin, Vitor H., and Paulo A S. Mourão. "Structure, Biology, Evolution, and Medical Importance of Sulfated Fucans and Galactans." Glycobiology, vol. 18, no. 12, 2008, pp. 1016-27.
Pomin VH, Mourão PA. Structure, biology, evolution, and medical importance of sulfated fucans and galactans. Glycobiology. 2008;18(12):1016-27.
Pomin, V. H., & Mourão, P. A. (2008). Structure, biology, evolution, and medical importance of sulfated fucans and galactans. Glycobiology, 18(12), 1016-27. https://doi.org/10.1093/glycob/cwn085
Pomin VH, Mourão PA. Structure, Biology, Evolution, and Medical Importance of Sulfated Fucans and Galactans. Glycobiology. 2008;18(12):1016-27. PubMed PMID: 18796647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure, biology, evolution, and medical importance of sulfated fucans and galactans. AU - Pomin,Vitor H, AU - Mourão,Paulo A S, Y1 - 2008/09/16/ PY - 2008/9/18/pubmed PY - 2009/2/14/medline PY - 2008/9/18/entrez SP - 1016 EP - 27 JF - Glycobiology JO - Glycobiology VL - 18 IS - 12 N2 - Sulfated fucans and galactans are strongly anionic polysaccharides found in marine organisms. Their structures vary among species, but their major features are conserved among phyla. Sulfated fucans are found in marine brown algae and echinoderms, whereas sulfated galactans occur in red and green algae, marine angiosperms, tunicates (ascidians), and sea urchins. Polysaccharides with 3-linked, beta-galactose units are highly conserved in some taxonomic groups of marine organisms and show a strong tendency toward 4-sulfation in algae and marine angiosperms, and 2-sulfation in invertebrates. Marine algae mainly express sulfated polysaccharides with complex, heterogeneous structures, whereas marine invertebrates synthesize sulfated fucans and sulfated galactans with regular repetitive structures. These polysaccharides are structural components of the extracellular matrix. Sulfated fucans and galactans are involved in sea urchin fertilization acting as species-specific inducers of the sperm acrosome reaction. Because of this function the structural evolution of sulfated fucans could be a component in the speciation process. The algal and invertebrate polysaccharides are also potent anticoagulant agents of mammalian blood and represent a potential source of compounds for antithrombotic therapies. SN - 1460-2423 UR - https://www.unboundmedicine.com/medline/citation/18796647/Structure_biology_evolution_and_medical_importance_of_sulfated_fucans_and_galactans_ L2 - https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwn085 DB - PRIME DP - Unbound Medicine ER -