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MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1.
J Clin Gastroenterol. 2009 Feb; 43(2):165-70.JC

Abstract

GOALS

To review magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP) findings in patients with diabetes mellitus (DM), with pancreatic exocrine insufficiency, and with combined pancreatic exocrine insufficiency and DM.

STUDY

MRI/MRCP findings of 82 consecutive patients with DM (n=28), pancreatic exocrine insufficiency (n=25), and combination of both (n=29) were evaluated and compared with MRI/MRCP findings of 21 healthy volunteers with normal pancreatic exocrine function. Pancreatic exocrine function was determined by fecal elastase 1. MRCP images were evaluated according to the Cambridge classification. MRI of the pancreas was assessed for pancreatic size, signal intensity ratio (SIR), and arterial/venous enhancement ratio (A/V).

RESULTS

On MRI, significant difference was present in terms of mean values of pancreatic size (P<0.0001), A/V (P<0.02), and SIR (P<0.005) between the control group and groups of patients with DM, pancreatic exocrine insufficiency, and combined DM and pancreatic exocrine insufficiency. No significant difference was observed between groups of patients with DM and pancreatic exocrine function alone in terms of pancreatic size, A/V, and SIR. Chronic pancreatitis MRCP findings were present with increasing frequency in groups of DM, pancreatic exocrine insufficiency, and combination of both.

CONCLUSIONS

MRI/MRCP findings suggesting chronic pancreatitis may exist in patients with DM comparable to patients with pancreatic exocrine insufficiency. The frequency and severity of MRI/MRCP findings increase when the patients have combined DM and pancreatic exocrine insufficiency.

Authors+Show Affiliations

Department of Radiology, University Hospital Giessen and Marburg, Giessen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18797409

Citation

Bilgin, Mehmet, et al. "MRI and MRCP Findings of the Pancreas in Patients With Diabetes Mellitus: Compared Analysis With Pancreatic Exocrine Function Determined By Fecal Elastase 1." Journal of Clinical Gastroenterology, vol. 43, no. 2, 2009, pp. 165-70.
Bilgin M, Balci NC, Momtahen AJ, et al. MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1. J Clin Gastroenterol. 2009;43(2):165-70.
Bilgin, M., Balci, N. C., Momtahen, A. J., Bilgin, Y., Klör, H. U., & Rau, W. S. (2009). MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1. Journal of Clinical Gastroenterology, 43(2), 165-70. https://doi.org/10.1097/MCG.0b013e3181587912
Bilgin M, et al. MRI and MRCP Findings of the Pancreas in Patients With Diabetes Mellitus: Compared Analysis With Pancreatic Exocrine Function Determined By Fecal Elastase 1. J Clin Gastroenterol. 2009;43(2):165-70. PubMed PMID: 18797409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1. AU - Bilgin,Mehmet, AU - Balci,Numan Cem, AU - Momtahen,Amir Javad, AU - Bilgin,Yaşar, AU - Klör,Hans-Ulrich, AU - Rau,Wigbert S, PY - 2008/9/18/pubmed PY - 2009/4/21/medline PY - 2008/9/18/entrez SP - 165 EP - 70 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 43 IS - 2 N2 - GOALS: To review magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP) findings in patients with diabetes mellitus (DM), with pancreatic exocrine insufficiency, and with combined pancreatic exocrine insufficiency and DM. STUDY: MRI/MRCP findings of 82 consecutive patients with DM (n=28), pancreatic exocrine insufficiency (n=25), and combination of both (n=29) were evaluated and compared with MRI/MRCP findings of 21 healthy volunteers with normal pancreatic exocrine function. Pancreatic exocrine function was determined by fecal elastase 1. MRCP images were evaluated according to the Cambridge classification. MRI of the pancreas was assessed for pancreatic size, signal intensity ratio (SIR), and arterial/venous enhancement ratio (A/V). RESULTS: On MRI, significant difference was present in terms of mean values of pancreatic size (P<0.0001), A/V (P<0.02), and SIR (P<0.005) between the control group and groups of patients with DM, pancreatic exocrine insufficiency, and combined DM and pancreatic exocrine insufficiency. No significant difference was observed between groups of patients with DM and pancreatic exocrine function alone in terms of pancreatic size, A/V, and SIR. Chronic pancreatitis MRCP findings were present with increasing frequency in groups of DM, pancreatic exocrine insufficiency, and combination of both. CONCLUSIONS: MRI/MRCP findings suggesting chronic pancreatitis may exist in patients with DM comparable to patients with pancreatic exocrine insufficiency. The frequency and severity of MRI/MRCP findings increase when the patients have combined DM and pancreatic exocrine insufficiency. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/18797409/MRI_and_MRCP_findings_of_the_pancreas_in_patients_with_diabetes_mellitus:_compared_analysis_with_pancreatic_exocrine_function_determined_by_fecal_elastase_1_ L2 - https://doi.org/10.1097/MCG.0b013e3181587912 DB - PRIME DP - Unbound Medicine ER -