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Multiparticulate drug delivery system of aceclofenac: development and in vitro studies.
Drug Dev Ind Pharm. 2009 Feb; 35(2):252-8.DD

Abstract

The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofenac, a nonsteroidal anti-inflammatory drug. The pellets were prepared by using extrusion/spheronization method, and the core pellets were coated with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve site-specific drug release. The formulated pellets were characterized for percentage yield, size distribution, surface morphology studies, drug content, and flow properties. In vitro dissolution test was used for comparison of drug release profiles of various coated pellets. The practical yield was found to be 90-95%. The particle size of enteric-coated pellets was found to be in the range of 0.59-0.71 mm. The pellets were spherical in shape and surfaces of pellets were found to be rough and showing micropores. Enteric-coated pellets showed good flow properties and in vitro dissolution profile. Dissolution tests were carried out in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the aceclofenac from formulated pellets was established to be minimum in the pH 1.2 (<5%) for a period of 2 h, and at pH 6.8, it shows the maximum release (85 +/- 5% release within 1 h) which indicates gastric resistance of the formulated pellets. The 20% wt/wt enteric-coated pellets were compared to that of marketed product (tablets), it was observed that pellets showed better release profile. The study concluded that the formulated multiparticulate dosage forms can be used as an ideal drug delivery system for the aceclofenac.

Authors+Show Affiliations

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18798090

Citation

Shavi, Gopal Venktesh, et al. "Multiparticulate Drug Delivery System of Aceclofenac: Development and in Vitro Studies." Drug Development and Industrial Pharmacy, vol. 35, no. 2, 2009, pp. 252-8.
Shavi GV, Nayak U, Averineni RK, et al. Multiparticulate drug delivery system of aceclofenac: development and in vitro studies. Drug Dev Ind Pharm. 2009;35(2):252-8.
Shavi, G. V., Nayak, U., Averineni, R. K., Arumugam, K., Meka, S. R., Nayanabhirama, U., & Sureshwar, P. (2009). Multiparticulate drug delivery system of aceclofenac: development and in vitro studies. Drug Development and Industrial Pharmacy, 35(2), 252-8. https://doi.org/10.1080/03639040802277680
Shavi GV, et al. Multiparticulate Drug Delivery System of Aceclofenac: Development and in Vitro Studies. Drug Dev Ind Pharm. 2009;35(2):252-8. PubMed PMID: 18798090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiparticulate drug delivery system of aceclofenac: development and in vitro studies. AU - Shavi,Gopal Venktesh, AU - Nayak,Usha, AU - Averineni,Ranjith Kumar, AU - Arumugam,Karthik, AU - Meka,Srinivasa Reddy, AU - Nayanabhirama,Udupa, AU - Sureshwar,Pandey, PY - 2008/9/18/pubmed PY - 2009/3/26/medline PY - 2008/9/18/entrez SP - 252 EP - 8 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 35 IS - 2 N2 - The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofenac, a nonsteroidal anti-inflammatory drug. The pellets were prepared by using extrusion/spheronization method, and the core pellets were coated with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve site-specific drug release. The formulated pellets were characterized for percentage yield, size distribution, surface morphology studies, drug content, and flow properties. In vitro dissolution test was used for comparison of drug release profiles of various coated pellets. The practical yield was found to be 90-95%. The particle size of enteric-coated pellets was found to be in the range of 0.59-0.71 mm. The pellets were spherical in shape and surfaces of pellets were found to be rough and showing micropores. Enteric-coated pellets showed good flow properties and in vitro dissolution profile. Dissolution tests were carried out in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the aceclofenac from formulated pellets was established to be minimum in the pH 1.2 (<5%) for a period of 2 h, and at pH 6.8, it shows the maximum release (85 +/- 5% release within 1 h) which indicates gastric resistance of the formulated pellets. The 20% wt/wt enteric-coated pellets were compared to that of marketed product (tablets), it was observed that pellets showed better release profile. The study concluded that the formulated multiparticulate dosage forms can be used as an ideal drug delivery system for the aceclofenac. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/18798090/Multiparticulate_drug_delivery_system_of_aceclofenac:_development_and_in_vitro_studies_ DB - PRIME DP - Unbound Medicine ER -