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Biochemotherapy in patients with advanced head and neck mucosal melanoma.
Head Neck. 2008 Dec; 30(12):1592-8.HN

Abstract

BACKGROUND

No systemic therapy regimen has been recognized as effective for metastatic mucosal melanoma of the head and neck. We retrospectively analyzed the effectiveness of biochemotherapy in patients with advanced head and neck mucosal melanoma.

METHODS

We evaluated the medical records of 15 patients at our institution who had received various biochemotherapy regimens for advanced head and neck mucosal melanoma.

RESULTS

After a median follow-up duration of 13 months, 3 patients (20%) had partial response, and 4 patients (27%) had complete response. The median time to disease progression for all 15 patients was 10 months. The median overall survival duration for all patients was 22 months.

CONCLUSIONS

Although this was a small study, our results, especially the high complete response and overall response rates, indicate that biochemotherapy for advanced head and neck mucosal melanoma should be considered as a systemic treatment option for patients with this aggressive malignancy.

Authors+Show Affiliations

The University of Texas Medical School at Houston, Houston, Texas, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18798304

Citation

Bartell, Holly L., et al. "Biochemotherapy in Patients With Advanced Head and Neck Mucosal Melanoma." Head & Neck, vol. 30, no. 12, 2008, pp. 1592-8.
Bartell HL, Bedikian AY, Papadopoulos NE, et al. Biochemotherapy in patients with advanced head and neck mucosal melanoma. Head Neck. 2008;30(12):1592-8.
Bartell, H. L., Bedikian, A. Y., Papadopoulos, N. E., Dett, T. K., Ballo, M. T., Myers, J. N., Hwu, P., & Kim, K. B. (2008). Biochemotherapy in patients with advanced head and neck mucosal melanoma. Head & Neck, 30(12), 1592-8. https://doi.org/10.1002/hed.20910
Bartell HL, et al. Biochemotherapy in Patients With Advanced Head and Neck Mucosal Melanoma. Head Neck. 2008;30(12):1592-8. PubMed PMID: 18798304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemotherapy in patients with advanced head and neck mucosal melanoma. AU - Bartell,Holly L, AU - Bedikian,Agop Y, AU - Papadopoulos,Nicholas E, AU - Dett,Tina K, AU - Ballo,Matthew T, AU - Myers,Jeffrey N, AU - Hwu,Patrick, AU - Kim,Kevin B, PY - 2008/9/18/pubmed PY - 2009/2/21/medline PY - 2008/9/18/entrez SP - 1592 EP - 8 JF - Head & neck JO - Head Neck VL - 30 IS - 12 N2 - BACKGROUND: No systemic therapy regimen has been recognized as effective for metastatic mucosal melanoma of the head and neck. We retrospectively analyzed the effectiveness of biochemotherapy in patients with advanced head and neck mucosal melanoma. METHODS: We evaluated the medical records of 15 patients at our institution who had received various biochemotherapy regimens for advanced head and neck mucosal melanoma. RESULTS: After a median follow-up duration of 13 months, 3 patients (20%) had partial response, and 4 patients (27%) had complete response. The median time to disease progression for all 15 patients was 10 months. The median overall survival duration for all patients was 22 months. CONCLUSIONS: Although this was a small study, our results, especially the high complete response and overall response rates, indicate that biochemotherapy for advanced head and neck mucosal melanoma should be considered as a systemic treatment option for patients with this aggressive malignancy. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/18798304/Biochemotherapy_in_patients_with_advanced_head_and_neck_mucosal_melanoma_ L2 - https://doi.org/10.1002/hed.20910 DB - PRIME DP - Unbound Medicine ER -