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'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.
BMC Med Genet 2008; 9:85BM

Abstract

BACKGROUND

We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this phenotype. The aim of this study was to investigate whether the obesity risk allele of one of these SNPs (rs9939609) is associated with weight loss in a lifestyle intervention program. Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism.

METHODS

We initially analysed rs9939609 in a case-control study comprising 519 German overweight and obese children and adolescents and 178 normal weight adults. In 207 of the obese individuals who took part in the outpatient obesity intervention program 'Obeldicks' we further analysed whether carrier status of the obesity risk A-allele of rs9939609 has a differential influence on weight loss after the intervention program. Additionally, we investigated in 480 of the overweight and obese patients whether rs9939609 is associated with fasting blood levels of glucose, triglycerides and HDL and LDL-cholesterol. Genotyping was performed using allele specific polymerase chain reaction (ARMS-PCR). For the association study (case-control approach), the Cochran-Armitage trend test was applied. Blood parameters were analysed using commercially available test kits and the log10-transformed blood parameters and changes in BMI-standard deviation scores (BMI-SDS) were analysed by linear regression with sex and age as covariates under an additive mode of inheritance with the rs9939609 A-allele as risk allele.

RESULTS

We confirmed the association of the risk A-allele of rs9939609 with overweight and early onset obesity (one sided p = 0.036). However, we observed no association of rs9939609 alleles with weight loss or fasting levels of blood glucose, triglycerides and cholesterol.

CONCLUSION

We confirmed the rs9939609 A-allele as a risk factor for early onset obesity whereas its impact on weight loss or on serum levels of glucose, triglycerides and cholesterol could not be detected in our samples.

TRIAL REGISTRATION

This study is registered at clinicaltrials.gov (NCT00435734).

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Essen, Germany. Timo.Mueller@uni-duisburg-essen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18799002

Citation

Müller, Timo D., et al. "'Fat Mass and Obesity Associated' Gene (FTO): No Significant Association of Variant Rs9939609 With Weight Loss in a Lifestyle Intervention and Lipid Metabolism Markers in German Obese Children and Adolescents." BMC Medical Genetics, vol. 9, 2008, p. 85.
Müller TD, Hinney A, Scherag A, et al. 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Med Genet. 2008;9:85.
Müller, T. D., Hinney, A., Scherag, A., Nguyen, T. T., Schreiner, F., Schäfer, H., ... Reinehr, T. (2008). 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Medical Genetics, 9, p. 85. doi:10.1186/1471-2350-9-85.
Müller TD, et al. 'Fat Mass and Obesity Associated' Gene (FTO): No Significant Association of Variant Rs9939609 With Weight Loss in a Lifestyle Intervention and Lipid Metabolism Markers in German Obese Children and Adolescents. BMC Med Genet. 2008 Sep 17;9:85. PubMed PMID: 18799002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. AU - Müller,Timo D, AU - Hinney,Anke, AU - Scherag,André, AU - Nguyen,Thuy T, AU - Schreiner,Felix, AU - Schäfer,Helmut, AU - Hebebrand,Johannes, AU - Roth,Christian L, AU - Reinehr,Thomas, Y1 - 2008/09/17/ PY - 2008/02/27/received PY - 2008/09/17/accepted PY - 2008/9/19/pubmed PY - 2008/10/4/medline PY - 2008/9/19/entrez SP - 85 EP - 85 JF - BMC medical genetics JO - BMC Med. Genet. VL - 9 N2 - BACKGROUND: We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this phenotype. The aim of this study was to investigate whether the obesity risk allele of one of these SNPs (rs9939609) is associated with weight loss in a lifestyle intervention program. Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism. METHODS: We initially analysed rs9939609 in a case-control study comprising 519 German overweight and obese children and adolescents and 178 normal weight adults. In 207 of the obese individuals who took part in the outpatient obesity intervention program 'Obeldicks' we further analysed whether carrier status of the obesity risk A-allele of rs9939609 has a differential influence on weight loss after the intervention program. Additionally, we investigated in 480 of the overweight and obese patients whether rs9939609 is associated with fasting blood levels of glucose, triglycerides and HDL and LDL-cholesterol. Genotyping was performed using allele specific polymerase chain reaction (ARMS-PCR). For the association study (case-control approach), the Cochran-Armitage trend test was applied. Blood parameters were analysed using commercially available test kits and the log10-transformed blood parameters and changes in BMI-standard deviation scores (BMI-SDS) were analysed by linear regression with sex and age as covariates under an additive mode of inheritance with the rs9939609 A-allele as risk allele. RESULTS: We confirmed the association of the risk A-allele of rs9939609 with overweight and early onset obesity (one sided p = 0.036). However, we observed no association of rs9939609 alleles with weight loss or fasting levels of blood glucose, triglycerides and cholesterol. CONCLUSION: We confirmed the rs9939609 A-allele as a risk factor for early onset obesity whereas its impact on weight loss or on serum levels of glucose, triglycerides and cholesterol could not be detected in our samples. TRIAL REGISTRATION: This study is registered at clinicaltrials.gov (NCT00435734). SN - 1471-2350 UR - https://www.unboundmedicine.com/medline/citation/18799002/'Fat_mass_and_obesity_associated'_gene__FTO_:_no_significant_association_of_variant_rs9939609_with_weight_loss_in_a_lifestyle_intervention_and_lipid_metabolism_markers_in_German_obese_children_and_adolescents_ L2 - https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-9-85 DB - PRIME DP - Unbound Medicine ER -