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Osteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses.
Osteoarthritis Cartilage. 2009 Mar; 17(3):371-4.OC

Abstract

OBJECTIVES

To investigate the effects of exercise and osteochondral (OC) injury on type II collagen degradation products (collagenase cleavage neoepitope commercially known as C2C) in synovial fluid (SF) from Thoroughbred (TB) racehorses and to compare these results with radiographic and arthroscopic scores of severity of joint injury.

METHODS

Metacarpophalangeal/metatarsophalangeal (MCP/MTP) and carpal SF was obtained from (1) 20 normal rested horses, (2) the same horses after 5 to 6 months of race training, and (3) 27 horses with OC injury from racing. For group 3, radiographic and arthroscopic scores were determined. Concentrations of SF C2C were determined by ELISA.

RESULTS

SF C2C concentrations in OC injured carpal and MCP/MTP joints were significantly different than rested and exercised joints (P<0.01). However, carpal and MCP/MTP SF C2C concentrations were not significantly different between rested and exercised groups. Arthroscopic scores were significantly higher for OC injured carpal than OC injured MCP/MTP joints (P=0.002). OC injured SF C2C concentrations were positively correlated with radiographic and arthroscopic scores. Arthroscopic scores were positively correlated with radiographic scores. SF C2C concentrations >or= 64 pmol/mL for MCP/MTP joints and >or= 75 pmol/mL for carpal joints discriminated OC injured joints from rested or exercised joints.

CONCLUSION

OC injury caused a significant increase in SF C2C concentrations in carpal and MCP/MTP joints compared to rested and exercised horses. SF C2C concentrations were correlated to severity of joint injury. Based on these findings, SF C2C analysis may be useful for evaluation of joint injury.

Authors+Show Affiliations

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18799328

Citation

Trumble, T N., et al. "Osteochondral Injury Increases Type II Collagen Degradation Products (C2C) in Synovial Fluid of Thoroughbred Racehorses." Osteoarthritis and Cartilage, vol. 17, no. 3, 2009, pp. 371-4.
Trumble TN, Scarbrough AB, Brown MP. Osteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses. Osteoarthr Cartil. 2009;17(3):371-4.
Trumble, T. N., Scarbrough, A. B., & Brown, M. P. (2009). Osteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses. Osteoarthritis and Cartilage, 17(3), 371-4. https://doi.org/10.1016/j.joca.2008.07.014
Trumble TN, Scarbrough AB, Brown MP. Osteochondral Injury Increases Type II Collagen Degradation Products (C2C) in Synovial Fluid of Thoroughbred Racehorses. Osteoarthr Cartil. 2009;17(3):371-4. PubMed PMID: 18799328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses. AU - Trumble,T N, AU - Scarbrough,A B, AU - Brown,M P, Y1 - 2008/09/16/ PY - 2008/04/16/received PY - 2008/07/20/accepted PY - 2008/9/19/pubmed PY - 2009/10/10/medline PY - 2008/9/19/entrez SP - 371 EP - 4 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 17 IS - 3 N2 - OBJECTIVES: To investigate the effects of exercise and osteochondral (OC) injury on type II collagen degradation products (collagenase cleavage neoepitope commercially known as C2C) in synovial fluid (SF) from Thoroughbred (TB) racehorses and to compare these results with radiographic and arthroscopic scores of severity of joint injury. METHODS: Metacarpophalangeal/metatarsophalangeal (MCP/MTP) and carpal SF was obtained from (1) 20 normal rested horses, (2) the same horses after 5 to 6 months of race training, and (3) 27 horses with OC injury from racing. For group 3, radiographic and arthroscopic scores were determined. Concentrations of SF C2C were determined by ELISA. RESULTS: SF C2C concentrations in OC injured carpal and MCP/MTP joints were significantly different than rested and exercised joints (P<0.01). However, carpal and MCP/MTP SF C2C concentrations were not significantly different between rested and exercised groups. Arthroscopic scores were significantly higher for OC injured carpal than OC injured MCP/MTP joints (P=0.002). OC injured SF C2C concentrations were positively correlated with radiographic and arthroscopic scores. Arthroscopic scores were positively correlated with radiographic scores. SF C2C concentrations >or= 64 pmol/mL for MCP/MTP joints and >or= 75 pmol/mL for carpal joints discriminated OC injured joints from rested or exercised joints. CONCLUSION: OC injury caused a significant increase in SF C2C concentrations in carpal and MCP/MTP joints compared to rested and exercised horses. SF C2C concentrations were correlated to severity of joint injury. Based on these findings, SF C2C analysis may be useful for evaluation of joint injury. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/18799328/Osteochondral_injury_increases_type_II_collagen_degradation_products__C2C__in_synovial_fluid_of_Thoroughbred_racehorses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(08)00249-5 DB - PRIME DP - Unbound Medicine ER -