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Cardiovascular risk in women with polycystic ovary syndrome.
J Cardiovasc Med (Hagerstown). 2008 Oct; 9(10):987-92.JC

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disease affecting about 5-10% of reproductive-age female population, which is predominantly characterized by chronic anovulation, hyperandrogenism and insulin resistance. PCOS women represent an intriguing biological model illustrating the relationship between hormonal pattern and cardiovascular risk profile, presenting a cluster of cardiovascular features, such as obesity, insulin resistance, hypertension, impaired cardiopulmonary functional capacity, autonomic dysfunction and low-grade chronic inflammation. Metabolic syndrome should be also considered in the clinical evaluation and management of PCOS. The treatment of PCOS and its complications should not be based solely on pharmacological therapies trying to improve hyperandrogenism, hyperinsulinemia and insulin resistance. Although mounting evidence recognizes the beneficial effects of lifestyle modifications, the clinical management of PCOS is not sufficiently focused on long-term maintenance of both exercise and dietary interventions and on further aspects of this syndrome (i.e. psychological status). Taking into consideration the patients' young age and the devastating effects of PCOS on hormonal and metabolic pattern, this complex and multifaceted disease requires a comprehensive approach in order to achieve concrete beneficial effects for PCOS patients. Multidisciplinary programs, including dietary and educational counseling, exercise training, stress management and psychosocial support, might represent the gold standard for adequate reduction of cardiovascular risk in young women with PCOS.

Authors+Show Affiliations

Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Naples, Italy. giallauria@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18799960

Citation

Giallauria, Francesco, et al. "Cardiovascular Risk in Women With Polycystic Ovary Syndrome." Journal of Cardiovascular Medicine (Hagerstown, Md.), vol. 9, no. 10, 2008, pp. 987-92.
Giallauria F, Orio F, Palomba S, et al. Cardiovascular risk in women with polycystic ovary syndrome. J Cardiovasc Med (Hagerstown). 2008;9(10):987-92.
Giallauria, F., Orio, F., Palomba, S., Lombardi, G., Colao, A., & Vigorito, C. (2008). Cardiovascular risk in women with polycystic ovary syndrome. Journal of Cardiovascular Medicine (Hagerstown, Md.), 9(10), 987-92. https://doi.org/10.2459/JCM.0b013e32830b58d4
Giallauria F, et al. Cardiovascular Risk in Women With Polycystic Ovary Syndrome. J Cardiovasc Med (Hagerstown). 2008;9(10):987-92. PubMed PMID: 18799960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk in women with polycystic ovary syndrome. AU - Giallauria,Francesco, AU - Orio,Francesco, AU - Palomba,Stefano, AU - Lombardi,Gaetano, AU - Colao,Annamaria, AU - Vigorito,Carlo, PY - 2008/9/19/pubmed PY - 2008/10/31/medline PY - 2008/9/19/entrez SP - 987 EP - 92 JF - Journal of cardiovascular medicine (Hagerstown, Md.) JO - J Cardiovasc Med (Hagerstown) VL - 9 IS - 10 N2 - Polycystic ovary syndrome (PCOS) is a heterogeneous disease affecting about 5-10% of reproductive-age female population, which is predominantly characterized by chronic anovulation, hyperandrogenism and insulin resistance. PCOS women represent an intriguing biological model illustrating the relationship between hormonal pattern and cardiovascular risk profile, presenting a cluster of cardiovascular features, such as obesity, insulin resistance, hypertension, impaired cardiopulmonary functional capacity, autonomic dysfunction and low-grade chronic inflammation. Metabolic syndrome should be also considered in the clinical evaluation and management of PCOS. The treatment of PCOS and its complications should not be based solely on pharmacological therapies trying to improve hyperandrogenism, hyperinsulinemia and insulin resistance. Although mounting evidence recognizes the beneficial effects of lifestyle modifications, the clinical management of PCOS is not sufficiently focused on long-term maintenance of both exercise and dietary interventions and on further aspects of this syndrome (i.e. psychological status). Taking into consideration the patients' young age and the devastating effects of PCOS on hormonal and metabolic pattern, this complex and multifaceted disease requires a comprehensive approach in order to achieve concrete beneficial effects for PCOS patients. Multidisciplinary programs, including dietary and educational counseling, exercise training, stress management and psychosocial support, might represent the gold standard for adequate reduction of cardiovascular risk in young women with PCOS. SN - 1558-2027 UR - https://www.unboundmedicine.com/medline/citation/18799960/Cardiovascular_risk_in_women_with_polycystic_ovary_syndrome_ L2 - https://doi.org/10.2459/JCM.0b013e32830b58d4 DB - PRIME DP - Unbound Medicine ER -