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Scintigraphic right-to-left liver lobe ratio and liver-to-spleen ratio in cirrhosis and non cirrhotic liver diseases.
J Assoc Physicians India. 1991 Mar; 39(3):265-7.JA

Abstract

Various criteria are used together for the scintigraphic diagnosis of cirrhosis as no single criterion may be reliable. However, low right-to-left hepatic lobe uptake ratio has been reported to be sensitive and specific for alcoholic cirrhosis. A low liver-to-spleen uptake ratio has also been reported in various hepatocellular disorders. We tested these ratios in patients with cirrhosis and non cirrhotic causes of portal hypertension. The right-to-left lobe uptake ratio was significantly lower (1.59 +/- 1.23 vs 2.36 +/- 0.63 in normals; p = 0.037) in only Child's C alcoholic cirrhosis, but the sensitivity of this ratio was low (40%) even in this subgroup of cirrhosis (mean +/- SD 1.72 +/- 1.08) as against 1 of 10 patients with non cirrhotic portal hypertension (3.57 +/- 1.33; p = 0.0005). We conclude that the right-to-left hepatic lobe uptake ratio is not a discriminatory scintigraphic sign in liver disease. A low liver-to-spleen uptake ratio can distinguish cirrhosis from non cirrhotic causes of portal hypertension.

Authors+Show Affiliations

Department of Gastroenterology, KEM Hospital, Bombay.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1880097

Citation

Khanna, M U., et al. "Scintigraphic Right-to-left Liver Lobe Ratio and Liver-to-spleen Ratio in Cirrhosis and Non Cirrhotic Liver Diseases." The Journal of the Association of Physicians of India, vol. 39, no. 3, 1991, pp. 265-7.
Khanna MU, Abraham P, Shikare SS, et al. Scintigraphic right-to-left liver lobe ratio and liver-to-spleen ratio in cirrhosis and non cirrhotic liver diseases. J Assoc Physicians India. 1991;39(3):265-7.
Khanna, M. U., Abraham, P., Shikare, S. S., & Tilve, G. H. (1991). Scintigraphic right-to-left liver lobe ratio and liver-to-spleen ratio in cirrhosis and non cirrhotic liver diseases. The Journal of the Association of Physicians of India, 39(3), 265-7.
Khanna MU, et al. Scintigraphic Right-to-left Liver Lobe Ratio and Liver-to-spleen Ratio in Cirrhosis and Non Cirrhotic Liver Diseases. J Assoc Physicians India. 1991;39(3):265-7. PubMed PMID: 1880097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scintigraphic right-to-left liver lobe ratio and liver-to-spleen ratio in cirrhosis and non cirrhotic liver diseases. AU - Khanna,M U, AU - Abraham,P, AU - Shikare,S S, AU - Tilve,G H, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 265 EP - 7 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 39 IS - 3 N2 - Various criteria are used together for the scintigraphic diagnosis of cirrhosis as no single criterion may be reliable. However, low right-to-left hepatic lobe uptake ratio has been reported to be sensitive and specific for alcoholic cirrhosis. A low liver-to-spleen uptake ratio has also been reported in various hepatocellular disorders. We tested these ratios in patients with cirrhosis and non cirrhotic causes of portal hypertension. The right-to-left lobe uptake ratio was significantly lower (1.59 +/- 1.23 vs 2.36 +/- 0.63 in normals; p = 0.037) in only Child's C alcoholic cirrhosis, but the sensitivity of this ratio was low (40%) even in this subgroup of cirrhosis (mean +/- SD 1.72 +/- 1.08) as against 1 of 10 patients with non cirrhotic portal hypertension (3.57 +/- 1.33; p = 0.0005). We conclude that the right-to-left hepatic lobe uptake ratio is not a discriminatory scintigraphic sign in liver disease. A low liver-to-spleen uptake ratio can distinguish cirrhosis from non cirrhotic causes of portal hypertension. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/1880097/Scintigraphic_right_to_left_liver_lobe_ratio_and_liver_to_spleen_ratio_in_cirrhosis_and_non_cirrhotic_liver_diseases_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -