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Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats.
Behav Brain Res. 2009 Jan 30; 197(1):178-85.BB

Abstract

Evidences from studies using electrical or chemical stimulation of the midbrain periaqueductal gray (PAG) suggest that whereas the dorsal PAG is critical for the regulation of panic-related defensive behaviors, the ventrolateral PAG (vlPAG) modulates generalized anxiety-related responses. In the present study we evaluated whether the activation of 5-HT1A and 5-HT2A/2C receptors in the ventrolateral column of the periaqueductal gray (vlPAG) causes differential effects on an anxiety- and a panic-related defensive behavior, respectively, inhibitory avoidance and escape, in male Wistar rats submitted to the elevated T-maze. Our results showed that intra-vlPAG injection of the endogenous agonist serotonin, the 5-HT1A/7 agonist 8-OH-DPAT or 5-HT2A/2C agonist DOI impaired the acquisition of inhibitory avoidance, without interfering with escape performance. The same selective anxiolytic effect was also observed after local administration of the benzodiazepine receptor agonist midazolam. Moreover, as shown by the results of antagonism studies, 5-HT2A receptors are recruited for the anxiolysis caused by serotonin and DOI, while 5-HT1A receptors account for the effect of 8-OH-DPAT. In conclusion, our data show that the activation of 5-HT1A and 5-HT2A receptors in the vlPAG affects defensive responses related to generalized anxiety, but not panic disorder.

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Publisher Full Text (DOI)

Authors+Show Affiliations

de Paula Soares V
Department of Pharmacology, School of Medicine, University of São Paulo, Av. Bandeirantes 3900, CEP: 14049-900 Ribeirão Preto, Brazil.
Zangrossi H
No affiliation info available

MeSH

Analysis of VarianceAnimalsAnti-Anxiety AgentsAnxiety DisordersAvoidance LearningEscape ReactionExploratory BehaviorMaleMidazolamPanic DisorderPeriaqueductal GrayRatsRats, WistarReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2ASerotonin Receptor AgonistsStatistics, Nonparametric

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18801389

Citation

de Paula Soares, Vanessa, and Hélio Zangrossi. "Stimulation of 5-HT1A or 5-HT2A Receptors in the Ventrolateral Periaqueductal Gray Causes Anxiolytic-, but Not Panicolytic-like Effect in Rats." Behavioural Brain Research, vol. 197, no. 1, 2009, pp. 178-85.
de Paula Soares V, Zangrossi H. Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats. Behav Brain Res. 2009;197(1):178-85.
de Paula Soares, V., & Zangrossi, H. (2009). Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats. Behavioural Brain Research, 197(1), 178-85. https://doi.org/10.1016/j.bbr.2008.08.027
de Paula Soares V, Zangrossi H. Stimulation of 5-HT1A or 5-HT2A Receptors in the Ventrolateral Periaqueductal Gray Causes Anxiolytic-, but Not Panicolytic-like Effect in Rats. Behav Brain Res. 2009 Jan 30;197(1):178-85. PubMed PMID: 18801389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats. AU - de Paula Soares,Vanessa, AU - Zangrossi,Hélio,Jr Y1 - 2008/08/29/ PY - 2008/05/09/received PY - 2008/08/14/revised PY - 2008/08/18/accepted PY - 2008/9/20/pubmed PY - 2009/4/11/medline PY - 2008/9/20/entrez SP - 178 EP - 85 JF - Behavioural brain research JO - Behav Brain Res VL - 197 IS - 1 N2 - Evidences from studies using electrical or chemical stimulation of the midbrain periaqueductal gray (PAG) suggest that whereas the dorsal PAG is critical for the regulation of panic-related defensive behaviors, the ventrolateral PAG (vlPAG) modulates generalized anxiety-related responses. In the present study we evaluated whether the activation of 5-HT1A and 5-HT2A/2C receptors in the ventrolateral column of the periaqueductal gray (vlPAG) causes differential effects on an anxiety- and a panic-related defensive behavior, respectively, inhibitory avoidance and escape, in male Wistar rats submitted to the elevated T-maze. Our results showed that intra-vlPAG injection of the endogenous agonist serotonin, the 5-HT1A/7 agonist 8-OH-DPAT or 5-HT2A/2C agonist DOI impaired the acquisition of inhibitory avoidance, without interfering with escape performance. The same selective anxiolytic effect was also observed after local administration of the benzodiazepine receptor agonist midazolam. Moreover, as shown by the results of antagonism studies, 5-HT2A receptors are recruited for the anxiolysis caused by serotonin and DOI, while 5-HT1A receptors account for the effect of 8-OH-DPAT. In conclusion, our data show that the activation of 5-HT1A and 5-HT2A receptors in the vlPAG affects defensive responses related to generalized anxiety, but not panic disorder. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/18801389/Stimulation_of_5_HT1A_or_5_HT2A_receptors_in_the_ventrolateral_periaqueductal_gray_causes_anxiolytic__but_not_panicolytic_like_effect_in_rats_ DB - PRIME DP - Unbound Medicine ER -