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Prevalence and clinical correlates of apathy in Parkinson's disease: a community-based study.
Parkinsonism Relat Disord. 2009 May; 15(4):295-9.PR

Abstract

The objective of this study was to examine the prevalence and clinical correlates of apathy in a population-based sample of patients with Parkinson's disease (PD) and to assess whether apathy may present as a primary behavioural disturbance independent from depression and cognitive impairment. A total of 232 patients derived from an epidemiological study of PD in Rogaland county, Western Norway, completed a comprehensive evaluation of motor, cognitive, and depressive symptoms. Apathy was assessed with the motivation/initiative item of the Unified Parkinson's Disease Rating Scale. The majority of the population had mild to moderate PD with mean disease duration of 9.1+/-5.7 years. Apathy was diagnosed in 38% of the 232 patients. In 11% of the total sample apathy coexisted with depression and dementia, whereas 10% had apathy and depression without dementia, 6.5% apathy and dementia without depression, and 9% were apathetic without dementia or depression (data missing in 1.5% patients). Apathy was significantly associated with higher depression scores, lower cognitive functioning, and more severe motor symptoms. When excluding patients with depression, dementia, cognitive impairment with no dementia (population-based age- and education-corrected norms for the Mini-Mental State Examination), and those using psychotropic medication, 5% of the 232 patients had apathy. In conclusion, our study shows that apathy is common in the general PD population, may present as an independent behavioural disorder, and suggests that apathy in PD may be related to dysfunction of the nigro-striatal pathway or that brain pathology underlying apathy and progression of motor symptoms develops in parallel.

Authors+Show Affiliations

The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway. pekf@sus.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18801696

Citation

Pedersen, Kenn Freddy, et al. "Prevalence and Clinical Correlates of Apathy in Parkinson's Disease: a Community-based Study." Parkinsonism & Related Disorders, vol. 15, no. 4, 2009, pp. 295-9.
Pedersen KF, Larsen JP, Alves G, et al. Prevalence and clinical correlates of apathy in Parkinson's disease: a community-based study. Parkinsonism Relat Disord. 2009;15(4):295-9.
Pedersen, K. F., Larsen, J. P., Alves, G., & Aarsland, D. (2009). Prevalence and clinical correlates of apathy in Parkinson's disease: a community-based study. Parkinsonism & Related Disorders, 15(4), 295-9. https://doi.org/10.1016/j.parkreldis.2008.07.006
Pedersen KF, et al. Prevalence and Clinical Correlates of Apathy in Parkinson's Disease: a Community-based Study. Parkinsonism Relat Disord. 2009;15(4):295-9. PubMed PMID: 18801696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and clinical correlates of apathy in Parkinson's disease: a community-based study. AU - Pedersen,Kenn Freddy, AU - Larsen,Jan Petter, AU - Alves,Guido, AU - Aarsland,Dag, Y1 - 2008/09/17/ PY - 2008/02/11/received PY - 2008/06/15/revised PY - 2008/07/25/accepted PY - 2008/9/20/pubmed PY - 2009/8/11/medline PY - 2008/9/20/entrez SP - 295 EP - 9 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 15 IS - 4 N2 - The objective of this study was to examine the prevalence and clinical correlates of apathy in a population-based sample of patients with Parkinson's disease (PD) and to assess whether apathy may present as a primary behavioural disturbance independent from depression and cognitive impairment. A total of 232 patients derived from an epidemiological study of PD in Rogaland county, Western Norway, completed a comprehensive evaluation of motor, cognitive, and depressive symptoms. Apathy was assessed with the motivation/initiative item of the Unified Parkinson's Disease Rating Scale. The majority of the population had mild to moderate PD with mean disease duration of 9.1+/-5.7 years. Apathy was diagnosed in 38% of the 232 patients. In 11% of the total sample apathy coexisted with depression and dementia, whereas 10% had apathy and depression without dementia, 6.5% apathy and dementia without depression, and 9% were apathetic without dementia or depression (data missing in 1.5% patients). Apathy was significantly associated with higher depression scores, lower cognitive functioning, and more severe motor symptoms. When excluding patients with depression, dementia, cognitive impairment with no dementia (population-based age- and education-corrected norms for the Mini-Mental State Examination), and those using psychotropic medication, 5% of the 232 patients had apathy. In conclusion, our study shows that apathy is common in the general PD population, may present as an independent behavioural disorder, and suggests that apathy in PD may be related to dysfunction of the nigro-striatal pathway or that brain pathology underlying apathy and progression of motor symptoms develops in parallel. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/18801696/Prevalence_and_clinical_correlates_of_apathy_in_Parkinson's_disease:_a_community_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(08)00231-9 DB - PRIME DP - Unbound Medicine ER -