Tags

Type your tag names separated by a space and hit enter

Poly(ether-ester) conjugates with enhanced degradation.
Biomacromolecules 2008; 9(10):2954-62B

Abstract

When a linear or a four arm star-shaped polyglycidol is used as macroinitiator, densely grafted poly(glycidol-graft-epsilon-caprolactone) and poly(glycidol-graft-L-lactide) and loosely grafted poly[(glycidol-graft-epsilon-caprolactone)-co-glycidol] copolymers have been synthesized by chemical or, in the latter case, by enzymatic catalyzed ring-opening polymerization of epsilon-caprolactone and L-lactide. The well-defined copolymers possess similar molecular weights, but differ in their architecture, microstructure and chemical composition. The hydrolytic degradation behavior was studied in a phosphate buffer solution at pH 7.4 and 37 degrees C for up to 90 days. After different time periods, the mass loss was determined and the degraded copolymers were analyzed by means of NMR, size exclusion chromatography, and scanning electron microscopy. Compared to linear poly(epsilon-caprolactone), poly[(glycidol-graft-epsilon-caprolactone)-co-glycidol] shows a change of the degradation mechanism and a tremendous enhancement of polymer degradation. As this effect is attributed to the high concentration of hydroxy groups at the polyglycidol backbone, this work points out a new possibility to tailor the degradation profiles of polyesters by the introduction of functionality into the polymeric material.

Authors+Show Affiliations

DWI an der RWTH Aachen e.V. and Institute of Technical and Macromolecular Chemistry, RWTH Aachen, Pauwelsstr. 8, D-52056 Aachen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18803418

Citation

Hans, Marc, et al. "Poly(ether-ester) Conjugates With Enhanced Degradation." Biomacromolecules, vol. 9, no. 10, 2008, pp. 2954-62.
Hans M, Keul H, Moeller M. Poly(ether-ester) conjugates with enhanced degradation. Biomacromolecules. 2008;9(10):2954-62.
Hans, M., Keul, H., & Moeller, M. (2008). Poly(ether-ester) conjugates with enhanced degradation. Biomacromolecules, 9(10), pp. 2954-62. doi:10.1021/bm8007499.
Hans M, Keul H, Moeller M. Poly(ether-ester) Conjugates With Enhanced Degradation. Biomacromolecules. 2008;9(10):2954-62. PubMed PMID: 18803418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly(ether-ester) conjugates with enhanced degradation. AU - Hans,Marc, AU - Keul,Helmut, AU - Moeller,Martin, Y1 - 2008/09/20/ PY - 2008/9/23/pubmed PY - 2009/5/2/medline PY - 2008/9/23/entrez SP - 2954 EP - 62 JF - Biomacromolecules JO - Biomacromolecules VL - 9 IS - 10 N2 - When a linear or a four arm star-shaped polyglycidol is used as macroinitiator, densely grafted poly(glycidol-graft-epsilon-caprolactone) and poly(glycidol-graft-L-lactide) and loosely grafted poly[(glycidol-graft-epsilon-caprolactone)-co-glycidol] copolymers have been synthesized by chemical or, in the latter case, by enzymatic catalyzed ring-opening polymerization of epsilon-caprolactone and L-lactide. The well-defined copolymers possess similar molecular weights, but differ in their architecture, microstructure and chemical composition. The hydrolytic degradation behavior was studied in a phosphate buffer solution at pH 7.4 and 37 degrees C for up to 90 days. After different time periods, the mass loss was determined and the degraded copolymers were analyzed by means of NMR, size exclusion chromatography, and scanning electron microscopy. Compared to linear poly(epsilon-caprolactone), poly[(glycidol-graft-epsilon-caprolactone)-co-glycidol] shows a change of the degradation mechanism and a tremendous enhancement of polymer degradation. As this effect is attributed to the high concentration of hydroxy groups at the polyglycidol backbone, this work points out a new possibility to tailor the degradation profiles of polyesters by the introduction of functionality into the polymeric material. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/18803418/Poly_ether_ester__conjugates_with_enhanced_degradation_ L2 - https://dx.doi.org/10.1021/bm8007499 DB - PRIME DP - Unbound Medicine ER -