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Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis.
Metabolism. 2008 Oct; 57(10):1414-21.M

Abstract

Adipokines including leptin, adiponectin, visfatin, resistin, and interleukin (IL)-6 significantly influence energy metabolism, insulin sensitivity, and cardiovascular health. In the current study, we investigated serum levels of these adipokines in diabetic and nondiabetic patients on maintenance hemodialysis (MD) as compared with controls with a glomerular filtration rate greater than 50 mL/min. Serum leptin, adiponectin, high-molecular-weight (HMW) adiponectin, visfatin, resistin, and IL-6 were determined by enzyme-linked immunosorbent assay in control (n = 60) and MD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation. Adiponectin, visfatin, resistin, and IL-6 were significantly elevated in MD patients as compared with controls. In multivariate analyses, sex and body mass index were independently correlated with serum leptin levels in both controls and MD patients. Furthermore, insulin resistance was independently and negatively associated with adiponectin and HMW adiponectin in both groups. Moreover, circulating resistin levels were independently correlated with serum visfatin concentrations in control and MD patients. However, various independent associations were only found in either controls or patients on MD. Thus, serum IL-6 levels were strongly and independently associated with C reactive protein and resistin in MD patients but not control subjects. We show that levels of various adipokines are significantly increased in MD patients. Furthermore, regulation of adipokines in vivo strongly depends on renal function. Regulation of HMW adiponectin is similar as compared with total adiponectin in the patients studied.

Authors+Show Affiliations

Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18803947

Citation

Ziegelmeier, Michaela, et al. "Adipokines Influencing Metabolic and Cardiovascular Disease Are Differentially Regulated in Maintenance Hemodialysis." Metabolism: Clinical and Experimental, vol. 57, no. 10, 2008, pp. 1414-21.
Ziegelmeier M, Bachmann A, Seeger J, et al. Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis. Metab Clin Exp. 2008;57(10):1414-21.
Ziegelmeier, M., Bachmann, A., Seeger, J., Lossner, U., Kratzsch, J., Blüher, M., Stumvoll, M., & Fasshauer, M. (2008). Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis. Metabolism: Clinical and Experimental, 57(10), 1414-21. https://doi.org/10.1016/j.metabol.2008.05.011
Ziegelmeier M, et al. Adipokines Influencing Metabolic and Cardiovascular Disease Are Differentially Regulated in Maintenance Hemodialysis. Metab Clin Exp. 2008;57(10):1414-21. PubMed PMID: 18803947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis. AU - Ziegelmeier,Michaela, AU - Bachmann,Anette, AU - Seeger,Jeannette, AU - Lossner,Ulrike, AU - Kratzsch,Jürgen, AU - Blüher,Matthias, AU - Stumvoll,Michael, AU - Fasshauer,Mathias, PY - 2007/11/06/received PY - 2008/05/19/accepted PY - 2008/9/23/pubmed PY - 2008/10/11/medline PY - 2008/9/23/entrez SP - 1414 EP - 21 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 57 IS - 10 N2 - Adipokines including leptin, adiponectin, visfatin, resistin, and interleukin (IL)-6 significantly influence energy metabolism, insulin sensitivity, and cardiovascular health. In the current study, we investigated serum levels of these adipokines in diabetic and nondiabetic patients on maintenance hemodialysis (MD) as compared with controls with a glomerular filtration rate greater than 50 mL/min. Serum leptin, adiponectin, high-molecular-weight (HMW) adiponectin, visfatin, resistin, and IL-6 were determined by enzyme-linked immunosorbent assay in control (n = 60) and MD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation. Adiponectin, visfatin, resistin, and IL-6 were significantly elevated in MD patients as compared with controls. In multivariate analyses, sex and body mass index were independently correlated with serum leptin levels in both controls and MD patients. Furthermore, insulin resistance was independently and negatively associated with adiponectin and HMW adiponectin in both groups. Moreover, circulating resistin levels were independently correlated with serum visfatin concentrations in control and MD patients. However, various independent associations were only found in either controls or patients on MD. Thus, serum IL-6 levels were strongly and independently associated with C reactive protein and resistin in MD patients but not control subjects. We show that levels of various adipokines are significantly increased in MD patients. Furthermore, regulation of adipokines in vivo strongly depends on renal function. Regulation of HMW adiponectin is similar as compared with total adiponectin in the patients studied. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/18803947/Adipokines_influencing_metabolic_and_cardiovascular_disease_are_differentially_regulated_in_maintenance_hemodialysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00197-2 DB - PRIME DP - Unbound Medicine ER -