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Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins.
Food Chem Toxicol. 2008 Nov; 46(11):3493-500.FC

Abstract

Saccharomyces cerevisiae extract (SCE) is used in cosmetics since it can act in oxidative stress and improve skin conditions. This study investigated dermatological effects of cosmetic formulations containing SCE and/or vitamins A, C and E. The formulation studied was supplemented or not (F1: vehicle) with vitamins A, C and E esters (F2) or with SCE (F3) or with the combination of vitamins and SCE (F4). Formulations were patch tested on back skin of volunteers. For efficacy studies, formulations were applied on volunteers and transepidermal water loss (TEWL), skin moisture (SM), skin microrelief (SMR) and free radicals protection were analysed after 3h, 15 and 30 days of application. Volunteers were also asked about efficacy perception. It was observed that F4 provoked a slight erythema in one volunteer. All formulations enhanced forearm SM. Only F3 and F4 presented long term effects on SMR and showed higher texture values; F3 had the highest brightness values. Our results suggest that vitamins and SCE showed effects in SM and SMR. Only formulations containing SC had long term effects in the improvement of SMR. Thus, these kinds of evaluations are very important in cosmetics development to evaluate the best risk and benefit correlation.

Authors+Show Affiliations

Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Av. do Café s/n, Bairro Monte Alegre, Ribeirão Preto, Sao Paulo 14 040-903, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18804142

Citation

Gaspar, L R., et al. "Evaluation of Dermatological Effects of Cosmetic Formulations Containing Saccharomyces Cerevisiae Extract and Vitamins." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 11, 2008, pp. 3493-500.
Gaspar LR, Camargo FB, Gianeti MD, et al. Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins. Food Chem Toxicol. 2008;46(11):3493-500.
Gaspar, L. R., Camargo, F. B., Gianeti, M. D., & Maia Campos, P. M. (2008). Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(11), 3493-500. https://doi.org/10.1016/j.fct.2008.08.028
Gaspar LR, et al. Evaluation of Dermatological Effects of Cosmetic Formulations Containing Saccharomyces Cerevisiae Extract and Vitamins. Food Chem Toxicol. 2008;46(11):3493-500. PubMed PMID: 18804142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins. AU - Gaspar,L R, AU - Camargo,F B,Jr AU - Gianeti,M D, AU - Maia Campos,P M B G, Y1 - 2008/09/02/ PY - 2008/05/09/received PY - 2008/08/07/revised PY - 2008/08/27/accepted PY - 2008/9/23/pubmed PY - 2009/1/7/medline PY - 2008/9/23/entrez SP - 3493 EP - 500 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 46 IS - 11 N2 - Saccharomyces cerevisiae extract (SCE) is used in cosmetics since it can act in oxidative stress and improve skin conditions. This study investigated dermatological effects of cosmetic formulations containing SCE and/or vitamins A, C and E. The formulation studied was supplemented or not (F1: vehicle) with vitamins A, C and E esters (F2) or with SCE (F3) or with the combination of vitamins and SCE (F4). Formulations were patch tested on back skin of volunteers. For efficacy studies, formulations were applied on volunteers and transepidermal water loss (TEWL), skin moisture (SM), skin microrelief (SMR) and free radicals protection were analysed after 3h, 15 and 30 days of application. Volunteers were also asked about efficacy perception. It was observed that F4 provoked a slight erythema in one volunteer. All formulations enhanced forearm SM. Only F3 and F4 presented long term effects on SMR and showed higher texture values; F3 had the highest brightness values. Our results suggest that vitamins and SCE showed effects in SM and SMR. Only formulations containing SC had long term effects in the improvement of SMR. Thus, these kinds of evaluations are very important in cosmetics development to evaluate the best risk and benefit correlation. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18804142/Evaluation_of_dermatological_effects_of_cosmetic_formulations_containing_Saccharomyces_cerevisiae_extract_and_vitamins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00468-7 DB - PRIME DP - Unbound Medicine ER -