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A family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population.
Diabetes Res Clin Pract. 2008 Nov; 82(2):268-75.DR

Abstract

AIM

To evaluate family history (FH) of type 2 diabetes (T2DM) as a risk factor for impaired fasting glucose (IFG), impaired glucose tolerance (IGT), T2DM and related metabolic traits in South East Asia and to compare the effects of a paternal versus maternal history.

METHODS

We studied 4717 men and women (68% Chinese, 18% Malays and 14% Asian Indians) living in Singapore. FH was considered positive if at least one first degree relative had T2DM. Obesity, fasting lipids, glucose and insulin levels were measured for all subjects. Insulin resistance (IR) was estimated by homeostasis model assessment (HOMA). An oral glucose tolerance test was carried for all subjects except those on diabetes medication.

RESULTS

A positive FH was associated with increased risk of IFG/IGT (OR=1.67, 95% CI=1.42-1.97) and T2DM (OR=2.95, 95% CI=2.36-3.70) as well as higher levels of obesity, HOMA-IR, fasting triglyceride (TG), and lower levels of high density lipoprotein (HDL) cholesterol and HOMA-beta. A maternal history of T2DM appeared to have a greater impact on obesity-related traits than a paternal history of T2DM. Compared to individuals with no FH of T2DM, a maternal history was associated with (i) greater body mass index (BMI) (24.15kg/m(2) vs. 23.42kg/m(2), p=0.016) and waist-to-hip ratio (WHR) (0.874 vs. 0.865, p=0.037) in men; and (ii) greater WHR (0.788 vs. 0.779, p=0.004), fasting triglyceride (1.23mmol/L vs. 1.09mmol/L, p<0.001), HOMA-IR (2.02 vs. 1.75, p<0.001), fasting plasma glucose (5.25mmol/L vs. 5.18mmol/L, p=0.005) and 2-h plasma glucose (6.01mmol/L vs. 5.78mmol/L, p=0.001) and lower HDL-C (1.41mmol/L vs. 1.47mmol/L, p=0.031) in women.

CONCLUSION

T2DM appears to be heritable in South East Asians with excess maternal transmission of obesity, IR and dyslipidemia.

Authors+Show Affiliations

Center for Molecular Epidemiology, National University of Singapore, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18804306

Citation

Tan, Jonathan T., et al. "A Family History of Type 2 Diabetes Is Associated With Glucose Intolerance and Obesity-related Traits With Evidence of Excess Maternal Transmission for Obesity-related Traits in a South East Asian Population." Diabetes Research and Clinical Practice, vol. 82, no. 2, 2008, pp. 268-75.
Tan JT, Tan LS, Chia KS, et al. A family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population. Diabetes Res Clin Pract. 2008;82(2):268-75.
Tan, J. T., Tan, L. S., Chia, K. S., Chew, S. K., & Tai, E. S. (2008). A family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population. Diabetes Research and Clinical Practice, 82(2), 268-75. https://doi.org/10.1016/j.diabres.2008.08.005
Tan JT, et al. A Family History of Type 2 Diabetes Is Associated With Glucose Intolerance and Obesity-related Traits With Evidence of Excess Maternal Transmission for Obesity-related Traits in a South East Asian Population. Diabetes Res Clin Pract. 2008;82(2):268-75. PubMed PMID: 18804306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population. AU - Tan,Jonathan T, AU - Tan,Luor Shyuan M, AU - Chia,Kee Seng, AU - Chew,Suok Kai, AU - Tai,E Shyong, Y1 - 2008/09/18/ PY - 2007/12/21/received PY - 2008/06/20/revised PY - 2008/08/08/accepted PY - 2008/9/23/pubmed PY - 2009/4/11/medline PY - 2008/9/23/entrez SP - 268 EP - 75 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 82 IS - 2 N2 - AIM: To evaluate family history (FH) of type 2 diabetes (T2DM) as a risk factor for impaired fasting glucose (IFG), impaired glucose tolerance (IGT), T2DM and related metabolic traits in South East Asia and to compare the effects of a paternal versus maternal history. METHODS: We studied 4717 men and women (68% Chinese, 18% Malays and 14% Asian Indians) living in Singapore. FH was considered positive if at least one first degree relative had T2DM. Obesity, fasting lipids, glucose and insulin levels were measured for all subjects. Insulin resistance (IR) was estimated by homeostasis model assessment (HOMA). An oral glucose tolerance test was carried for all subjects except those on diabetes medication. RESULTS: A positive FH was associated with increased risk of IFG/IGT (OR=1.67, 95% CI=1.42-1.97) and T2DM (OR=2.95, 95% CI=2.36-3.70) as well as higher levels of obesity, HOMA-IR, fasting triglyceride (TG), and lower levels of high density lipoprotein (HDL) cholesterol and HOMA-beta. A maternal history of T2DM appeared to have a greater impact on obesity-related traits than a paternal history of T2DM. Compared to individuals with no FH of T2DM, a maternal history was associated with (i) greater body mass index (BMI) (24.15kg/m(2) vs. 23.42kg/m(2), p=0.016) and waist-to-hip ratio (WHR) (0.874 vs. 0.865, p=0.037) in men; and (ii) greater WHR (0.788 vs. 0.779, p=0.004), fasting triglyceride (1.23mmol/L vs. 1.09mmol/L, p<0.001), HOMA-IR (2.02 vs. 1.75, p<0.001), fasting plasma glucose (5.25mmol/L vs. 5.18mmol/L, p=0.005) and 2-h plasma glucose (6.01mmol/L vs. 5.78mmol/L, p=0.001) and lower HDL-C (1.41mmol/L vs. 1.47mmol/L, p=0.031) in women. CONCLUSION: T2DM appears to be heritable in South East Asians with excess maternal transmission of obesity, IR and dyslipidemia. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18804306/A_family_history_of_type_2_diabetes_is_associated_with_glucose_intolerance_and_obesity_related_traits_with_evidence_of_excess_maternal_transmission_for_obesity_related_traits_in_a_South_East_Asian_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00382-3 DB - PRIME DP - Unbound Medicine ER -