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Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress.
Psychoneuroendocrinology. 2008 Nov; 33(10):1394-400.P

Abstract

Previous studies have shown that intranasally administered insulin exerts an inhibitory influence on the basal hypothalamic-pituitary-adrenal (HPA) axis activity. To date, however, it remains unclear as to whether intranasal insulin does furthermore affect HPA axis responsiveness in situations of stress. Here, we tested whether intranasally administered insulin attenuates the HPA axis response to psychosocial stress. Fifty minutes before being exposed to the Trier Social Stress Test (TSST), 26 healthy young male participants received a single intranasal dose of human insulin (40 I.U.) or placebo in a placebo controlled, double-blind between-subject design. Plasma cortisol, saliva cortisol, heart rate, and blood pressure were measured at resting baseline and in response to the TSST. Plasma cortisol (P<.001) and saliva cortisol (P<.001) increased in response to stress, as did heart rate (P<.001) and blood pressure (P<.001). Intranasal insulin did not influence plasma or saliva cortisol, heart rate, blood pressure, blood glucose, and plasma insulin levels at baseline. However, intranasal insulin diminished the saliva cortisol (two-way ANOVA; treatment by time interaction: P=.05) and plasma cortisol (two-way ANOVA; treatment by time interaction: P=.05) response to the TSST without affecting heart rate, and blood pressure stress reactivity. Our data show that a single intranasal insulin administration effectively lowers stress-induced HPA axis responsiveness. Intranasal insulin may offer a therapeutic potential to prevent hyperactivity of the HPA system.

Authors+Show Affiliations

Department of Clinical Physiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. boeh1303@uni-trier.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18804330

Citation

Bohringer, Andreas, et al. "Intranasal Insulin Attenuates the Hypothalamic-pituitary-adrenal Axis Response to Psychosocial Stress." Psychoneuroendocrinology, vol. 33, no. 10, 2008, pp. 1394-400.
Bohringer A, Schwabe L, Richter S, et al. Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress. Psychoneuroendocrinology. 2008;33(10):1394-400.
Bohringer, A., Schwabe, L., Richter, S., & Schachinger, H. (2008). Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress. Psychoneuroendocrinology, 33(10), 1394-400. https://doi.org/10.1016/j.psyneuen.2008.08.002
Bohringer A, et al. Intranasal Insulin Attenuates the Hypothalamic-pituitary-adrenal Axis Response to Psychosocial Stress. Psychoneuroendocrinology. 2008;33(10):1394-400. PubMed PMID: 18804330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress. AU - Bohringer,Andreas, AU - Schwabe,Lars, AU - Richter,Steffen, AU - Schachinger,Hartmut, Y1 - 2008/09/18/ PY - 2008/05/28/received PY - 2008/07/08/revised PY - 2008/08/06/accepted PY - 2008/9/23/pubmed PY - 2009/2/7/medline PY - 2008/9/23/entrez SP - 1394 EP - 400 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 33 IS - 10 N2 - Previous studies have shown that intranasally administered insulin exerts an inhibitory influence on the basal hypothalamic-pituitary-adrenal (HPA) axis activity. To date, however, it remains unclear as to whether intranasal insulin does furthermore affect HPA axis responsiveness in situations of stress. Here, we tested whether intranasally administered insulin attenuates the HPA axis response to psychosocial stress. Fifty minutes before being exposed to the Trier Social Stress Test (TSST), 26 healthy young male participants received a single intranasal dose of human insulin (40 I.U.) or placebo in a placebo controlled, double-blind between-subject design. Plasma cortisol, saliva cortisol, heart rate, and blood pressure were measured at resting baseline and in response to the TSST. Plasma cortisol (P<.001) and saliva cortisol (P<.001) increased in response to stress, as did heart rate (P<.001) and blood pressure (P<.001). Intranasal insulin did not influence plasma or saliva cortisol, heart rate, blood pressure, blood glucose, and plasma insulin levels at baseline. However, intranasal insulin diminished the saliva cortisol (two-way ANOVA; treatment by time interaction: P=.05) and plasma cortisol (two-way ANOVA; treatment by time interaction: P=.05) response to the TSST without affecting heart rate, and blood pressure stress reactivity. Our data show that a single intranasal insulin administration effectively lowers stress-induced HPA axis responsiveness. Intranasal insulin may offer a therapeutic potential to prevent hyperactivity of the HPA system. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/18804330/Intranasal_insulin_attenuates_the_hypothalamic_pituitary_adrenal_axis_response_to_psychosocial_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(08)00207-2 DB - PRIME DP - Unbound Medicine ER -