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A pilot study on intradermal vaccination of Japanese rabies vaccine for pre-exposure immunization.
Vaccine. 2008 Nov 25; 26(50):6441-4.V

Abstract

Japanese rabies vaccine, a purified chick embryo cell vaccine manufactured by Kaketsuken (PCEC-K), is normally given subcutaneously; however, this requires a large amount of vaccine, and the pre-exposure vaccination regimen requires 6 months to complete. These factors often hamper appropriate vaccination. Therefore, we examined whether this vaccine could induce adequate level of viral neutralizing antibody (VNA) when vaccinated according to the World Health Organization (WHO) intradermal regimen. Our pilot study showed that this regimen resulted in all subjects developing adequate VNA levels. Intradermal route was effective not only for pre-exposure but also for booster vaccination. The intradermal PCEC-K regimen was found to be safe and effective in inducing adequate VNA levels with the use of a smaller quantity of vaccine and within a shorter period of time.

Authors+Show Affiliations

Department of Infectious Diseases Microbiology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu City, Oita 879-5593, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18804510

Citation

Shiota, Seiji, et al. "A Pilot Study On Intradermal Vaccination of Japanese Rabies Vaccine for Pre-exposure Immunization." Vaccine, vol. 26, no. 50, 2008, pp. 6441-4.
Shiota S, Khawplod P, Ahmed K, et al. A pilot study on intradermal vaccination of Japanese rabies vaccine for pre-exposure immunization. Vaccine. 2008;26(50):6441-4.
Shiota, S., Khawplod, P., Ahmed, K., Mifune, K., & Nishizono, A. (2008). A pilot study on intradermal vaccination of Japanese rabies vaccine for pre-exposure immunization. Vaccine, 26(50), 6441-4. https://doi.org/10.1016/j.vaccine.2008.08.068
Shiota S, et al. A Pilot Study On Intradermal Vaccination of Japanese Rabies Vaccine for Pre-exposure Immunization. Vaccine. 2008 Nov 25;26(50):6441-4. PubMed PMID: 18804510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot study on intradermal vaccination of Japanese rabies vaccine for pre-exposure immunization. AU - Shiota,Seiji, AU - Khawplod,Pakamatz, AU - Ahmed,Kamruddin, AU - Mifune,Kumato, AU - Nishizono,Akira, Y1 - 2008/09/18/ PY - 2008/02/13/received PY - 2008/04/14/revised PY - 2008/08/05/accepted PY - 2008/9/23/pubmed PY - 2009/2/10/medline PY - 2008/9/23/entrez SP - 6441 EP - 4 JF - Vaccine JO - Vaccine VL - 26 IS - 50 N2 - Japanese rabies vaccine, a purified chick embryo cell vaccine manufactured by Kaketsuken (PCEC-K), is normally given subcutaneously; however, this requires a large amount of vaccine, and the pre-exposure vaccination regimen requires 6 months to complete. These factors often hamper appropriate vaccination. Therefore, we examined whether this vaccine could induce adequate level of viral neutralizing antibody (VNA) when vaccinated according to the World Health Organization (WHO) intradermal regimen. Our pilot study showed that this regimen resulted in all subjects developing adequate VNA levels. Intradermal route was effective not only for pre-exposure but also for booster vaccination. The intradermal PCEC-K regimen was found to be safe and effective in inducing adequate VNA levels with the use of a smaller quantity of vaccine and within a shorter period of time. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/18804510/A_pilot_study_on_intradermal_vaccination_of_Japanese_rabies_vaccine_for_pre_exposure_immunization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(08)01214-0 DB - PRIME DP - Unbound Medicine ER -