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Intralaminar nuclei of the thalamus in Lewy body diseases.
Brain Res Bull. 2009 Feb 16; 78(2-3):97-104.BR

Abstract

Although the intralaminar thalamus is a target of alpha-synuclein pathology in Parkinson's disease, the degree of neuronal loss in Lewy body diseases has not been assessed. We have used unbiased stereological techniques to quantify neuronal loss in intralaminar thalamic nuclei concentrating alpha-synuclein pathology (the anterodorsal, cucullar, parataenial, paraventricular, central medial, central lateral and centre-median/parafascicular complex) in different clinical forms of Lewy body disease (Parkinson's disease with and without dementia, and dementia with Lewy bodies, N=21) compared with controls (N=5). Associations were performed in the Lewy body cases between intralaminar cell loss and the main diagnostic clinical (parkinsonism, dementia, fluctuation in consciousness, and visual hallucinations) and pathological (Braak stage of Parkinson's disease) features of these diseases, as well as between cell loss and the scaled severity of the alpha-synuclein deposition within the intralaminar thalamus. As expected, significant alpha-synuclein accumulation occurred in the intralaminar thalamus in the cases with Lewy body disease. Pathology concentrated anteriorly and in the central lateral and paraventricular nuclei was related to the Braak stage of Parkinson's disease, ageing, and the presence of dementia. Across all types of Lewy body cases there was substantial atrophy and neuronal loss in the central lateral, cucullar and parataenial nuclei, and neuronal loss without atrophy in the centre-median/parafascicular complex. Cases with visual hallucinations showed a greater degree of atrophy of the cucullar nucleus, possibly due to amygdala denervation. The significant degeneration demonstrated in the intralaminar thalamus is likely to contribute to the movement and cognitive dysfunction observed in Lewy body disorders.

Authors+Show Affiliations

Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18804518

Citation

Brooks, Daniel, and Glenda M. Halliday. "Intralaminar Nuclei of the Thalamus in Lewy Body Diseases." Brain Research Bulletin, vol. 78, no. 2-3, 2009, pp. 97-104.
Brooks D, Halliday GM. Intralaminar nuclei of the thalamus in Lewy body diseases. Brain Res Bull. 2009;78(2-3):97-104.
Brooks, D., & Halliday, G. M. (2009). Intralaminar nuclei of the thalamus in Lewy body diseases. Brain Research Bulletin, 78(2-3), 97-104. https://doi.org/10.1016/j.brainresbull.2008.08.014
Brooks D, Halliday GM. Intralaminar Nuclei of the Thalamus in Lewy Body Diseases. Brain Res Bull. 2009 Feb 16;78(2-3):97-104. PubMed PMID: 18804518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intralaminar nuclei of the thalamus in Lewy body diseases. AU - Brooks,Daniel, AU - Halliday,Glenda M, Y1 - 2008/09/18/ PY - 2008/9/23/pubmed PY - 2009/3/24/medline PY - 2008/9/23/entrez SP - 97 EP - 104 JF - Brain research bulletin JO - Brain Res Bull VL - 78 IS - 2-3 N2 - Although the intralaminar thalamus is a target of alpha-synuclein pathology in Parkinson's disease, the degree of neuronal loss in Lewy body diseases has not been assessed. We have used unbiased stereological techniques to quantify neuronal loss in intralaminar thalamic nuclei concentrating alpha-synuclein pathology (the anterodorsal, cucullar, parataenial, paraventricular, central medial, central lateral and centre-median/parafascicular complex) in different clinical forms of Lewy body disease (Parkinson's disease with and without dementia, and dementia with Lewy bodies, N=21) compared with controls (N=5). Associations were performed in the Lewy body cases between intralaminar cell loss and the main diagnostic clinical (parkinsonism, dementia, fluctuation in consciousness, and visual hallucinations) and pathological (Braak stage of Parkinson's disease) features of these diseases, as well as between cell loss and the scaled severity of the alpha-synuclein deposition within the intralaminar thalamus. As expected, significant alpha-synuclein accumulation occurred in the intralaminar thalamus in the cases with Lewy body disease. Pathology concentrated anteriorly and in the central lateral and paraventricular nuclei was related to the Braak stage of Parkinson's disease, ageing, and the presence of dementia. Across all types of Lewy body cases there was substantial atrophy and neuronal loss in the central lateral, cucullar and parataenial nuclei, and neuronal loss without atrophy in the centre-median/parafascicular complex. Cases with visual hallucinations showed a greater degree of atrophy of the cucullar nucleus, possibly due to amygdala denervation. The significant degeneration demonstrated in the intralaminar thalamus is likely to contribute to the movement and cognitive dysfunction observed in Lewy body disorders. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/18804518/Intralaminar_nuclei_of_the_thalamus_in_Lewy_body_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(08)00293-1 DB - PRIME DP - Unbound Medicine ER -