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Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome.
Nutr Metab Cardiovasc Dis. 2009 May; 19(4):264-70.NM

Abstract

BACKGROUND AND AIMS

Animal studies show that ecosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are effective for the prevention and treatment of insulin resistance (IR). Data from human studies are contradictory. We sought to determine whether the relationships between plasma n-3 and n-6 polyunsaturated fatty acid (FA) levels and IR differ according to the presence or absence of metabolic syndrome (MS) in a coronary heart disease sample.

METHOD AND RESULTS

Clinical, metabolic parameters, plasma phospholipid FA profiles and indirect measurement of IR (homeostatic model assessment-HOMA) were measured in 734 subjects, 8 weeks following acute coronary syndrome. FA levels and their correlations with IR were compared in subjects with and without MS. MS patients had higher saturated (16:0, 18:0) and n-6 (18:3n-6, 20:3n-6, 22:4n-6, 22:5n-6) FA levels, and lower EPA and DHA levels. HOMA-IR correlated positively with total saturated (r=0.13, P=0.017) and n-6 (r=0.17, P=0.001) FA levels and negatively with total n-3 FA levels (r=-0.13, P=0.012), in MS subjects only. Total n-3 and n-6 FAs and n-6/n-3 ratio were associated with HOMA-IR levels in MS subjects independent of total saturated FA levels, age, sex, sedentary behaviour, smoking, waist circumference, triglycerides, HDL-cholesterol, and systolic blood pressure.

CONCLUSIONS

Relationships between polyunsaturated FA type and IR vary according to the presence or absence of MS. N-3 FAs including EPA and DHA are associated with lower HOMA-IR, while the opposite is true for n-6 FAs. Prospective studies are required to address the potential effects of intermediate dose EPA and DHA on glucose handling in MS patients.

Authors+Show Affiliations

Research Center, Montreal Heart Institute, Université de Montréal, 5000 Bélanger Street, Montreal, Quebec, Canada. anil.nigam@icm-mhi.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18804984

Citation

Nigam, A, et al. "Relationship Between N-3 and N-6 Plasma Fatty Acid Levels and Insulin Resistance in Coronary Patients With and Without Metabolic Syndrome." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 4, 2009, pp. 264-70.
Nigam A, Frasure-Smith N, Lespérance F, et al. Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. Nutr Metab Cardiovasc Dis. 2009;19(4):264-70.
Nigam, A., Frasure-Smith, N., Lespérance, F., & Julien, P. (2009). Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(4), 264-70. https://doi.org/10.1016/j.numecd.2008.07.008
Nigam A, et al. Relationship Between N-3 and N-6 Plasma Fatty Acid Levels and Insulin Resistance in Coronary Patients With and Without Metabolic Syndrome. Nutr Metab Cardiovasc Dis. 2009;19(4):264-70. PubMed PMID: 18804984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. AU - Nigam,A, AU - Frasure-Smith,N, AU - Lespérance,F, AU - Julien,P, Y1 - 2008/09/20/ PY - 2008/01/17/received PY - 2008/06/26/revised PY - 2008/07/18/accepted PY - 2008/9/23/pubmed PY - 2009/7/25/medline PY - 2008/9/23/entrez SP - 264 EP - 70 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 4 N2 - BACKGROUND AND AIMS: Animal studies show that ecosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are effective for the prevention and treatment of insulin resistance (IR). Data from human studies are contradictory. We sought to determine whether the relationships between plasma n-3 and n-6 polyunsaturated fatty acid (FA) levels and IR differ according to the presence or absence of metabolic syndrome (MS) in a coronary heart disease sample. METHOD AND RESULTS: Clinical, metabolic parameters, plasma phospholipid FA profiles and indirect measurement of IR (homeostatic model assessment-HOMA) were measured in 734 subjects, 8 weeks following acute coronary syndrome. FA levels and their correlations with IR were compared in subjects with and without MS. MS patients had higher saturated (16:0, 18:0) and n-6 (18:3n-6, 20:3n-6, 22:4n-6, 22:5n-6) FA levels, and lower EPA and DHA levels. HOMA-IR correlated positively with total saturated (r=0.13, P=0.017) and n-6 (r=0.17, P=0.001) FA levels and negatively with total n-3 FA levels (r=-0.13, P=0.012), in MS subjects only. Total n-3 and n-6 FAs and n-6/n-3 ratio were associated with HOMA-IR levels in MS subjects independent of total saturated FA levels, age, sex, sedentary behaviour, smoking, waist circumference, triglycerides, HDL-cholesterol, and systolic blood pressure. CONCLUSIONS: Relationships between polyunsaturated FA type and IR vary according to the presence or absence of MS. N-3 FAs including EPA and DHA are associated with lower HOMA-IR, while the opposite is true for n-6 FAs. Prospective studies are required to address the potential effects of intermediate dose EPA and DHA on glucose handling in MS patients. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/18804984/Relationship_between_n_3_and_n_6_plasma_fatty_acid_levels_and_insulin_resistance_in_coronary_patients_with_and_without_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00162-2 DB - PRIME DP - Unbound Medicine ER -