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High vitamin C intake is associated with lower 4-year bone loss in elderly men.
J Nutr 2008; 138(10):1931-8JN

Abstract

Vitamin C is essential for collagen formation and normal bone development. We evaluated associations of total, supplemental, and dietary vitamin C intake with bone mineral density (BMD) at the hip [femoral neck, trochanter], spine, and radial shaft and 4-y BMD change in elderly participants from the Framingham Osteoporosis Study. Energy-adjusted vitamin C intakes were estimated from the Willett FFQ in 1988-89. Mean BMD and 4-y BMD change was estimated, for men and women, by tertile/category of vitamin C intake, adjusting for covariates. We tested for interaction with smoking, calcium, and vitamin E intake. Among 334 men and 540 women, the mean age was 75 y and mean vitamin D intake was 8.25 mug/d (women) and 8.05 mug/d (men). We observed negative associations between total and supplemental vitamin C intake and trochanter-BMD among current male smokers (P-trend = 0.01). Among male nonsmokers, total vitamin C intake was positively associated with femoral neck BMD (P-trend = 0.04). Higher total vitamin C intake was associated with less femoral neck and trochanter-BMD loss in men with low calcium (all P-trend </= 0.03) or vitamin E intakes (all P-trend = 0.03). Higher dietary vitamin C intake tended to be associated with lower femoral neck-BMD loss (P-trend = 0.09). These associations were attenuated but retained borderline significance (P-trend < 0.1) after adjusting for potassium intake (a marker of fruit and vegetable intake), suggesting that vitamin C effects may not be separated from other protective factors in fruit and vegetables. Null associations were observed among women. These results suggest a possible protective role of vitamin C for bone health in older men.

Authors+Show Affiliations

Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18806103

Citation

Sahni, Shivani, et al. "High Vitamin C Intake Is Associated With Lower 4-year Bone Loss in Elderly Men." The Journal of Nutrition, vol. 138, no. 10, 2008, pp. 1931-8.
Sahni S, Hannan MT, Gagnon D, et al. High vitamin C intake is associated with lower 4-year bone loss in elderly men. J Nutr. 2008;138(10):1931-8.
Sahni, S., Hannan, M. T., Gagnon, D., Blumberg, J., Cupples, L. A., Kiel, D. P., & Tucker, K. L. (2008). High vitamin C intake is associated with lower 4-year bone loss in elderly men. The Journal of Nutrition, 138(10), pp. 1931-8.
Sahni S, et al. High Vitamin C Intake Is Associated With Lower 4-year Bone Loss in Elderly Men. J Nutr. 2008;138(10):1931-8. PubMed PMID: 18806103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High vitamin C intake is associated with lower 4-year bone loss in elderly men. AU - Sahni,Shivani, AU - Hannan,Marian T, AU - Gagnon,David, AU - Blumberg,Jeffrey, AU - Cupples,L Adrienne, AU - Kiel,Douglas P, AU - Tucker,Katherine L, PY - 2008/9/23/pubmed PY - 2008/12/17/medline PY - 2008/9/23/entrez SP - 1931 EP - 8 JF - The Journal of nutrition JO - J. Nutr. VL - 138 IS - 10 N2 - Vitamin C is essential for collagen formation and normal bone development. We evaluated associations of total, supplemental, and dietary vitamin C intake with bone mineral density (BMD) at the hip [femoral neck, trochanter], spine, and radial shaft and 4-y BMD change in elderly participants from the Framingham Osteoporosis Study. Energy-adjusted vitamin C intakes were estimated from the Willett FFQ in 1988-89. Mean BMD and 4-y BMD change was estimated, for men and women, by tertile/category of vitamin C intake, adjusting for covariates. We tested for interaction with smoking, calcium, and vitamin E intake. Among 334 men and 540 women, the mean age was 75 y and mean vitamin D intake was 8.25 mug/d (women) and 8.05 mug/d (men). We observed negative associations between total and supplemental vitamin C intake and trochanter-BMD among current male smokers (P-trend = 0.01). Among male nonsmokers, total vitamin C intake was positively associated with femoral neck BMD (P-trend = 0.04). Higher total vitamin C intake was associated with less femoral neck and trochanter-BMD loss in men with low calcium (all P-trend </= 0.03) or vitamin E intakes (all P-trend = 0.03). Higher dietary vitamin C intake tended to be associated with lower femoral neck-BMD loss (P-trend = 0.09). These associations were attenuated but retained borderline significance (P-trend < 0.1) after adjusting for potassium intake (a marker of fruit and vegetable intake), suggesting that vitamin C effects may not be separated from other protective factors in fruit and vegetables. Null associations were observed among women. These results suggest a possible protective role of vitamin C for bone health in older men. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/18806103/High_vitamin_C_intake_is_associated_with_lower_4_year_bone_loss_in_elderly_men_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/138.10.1931 DB - PRIME DP - Unbound Medicine ER -