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Assessment of serum anti-Bordetella pertussis antibody titers among medical staff members.
Jpn J Infect Dis. 2008 Sep; 61(5):371-4.JJ

Abstract

This study comparatively evaluated the titers of the bacterial agglutination (BA) antibody for Bordetella pertussis, anti-pertussis toxin (PT) antibody, and anti-filamentous hemagglutinin (FHA) antibody in the serum of medical staff members. The geometric means of the anti-PT and anti-FHA antibody titers were 5.83 and 17.17 EU/mL, respectively. The positive rates of the BA antibodies against Tohama and Yamaguchi strains (> or = 40x), and anti-PT and anti-FHA antibodies (>10 EU/mL) were 81.3, 72.9, 43.8, and 68.8%, respectively. A high anti-PT antibody titer (>94 EU/mL) was found in 1 staff member, but this individual had no recent respiratory symptoms. The titers of the BA antibody against the Yamaguchi strain were weakly associated with the anti-PT antibody titers, but the BA antibody titer was not useful for predicting anti-PT antibody positivity. The seroprevalence of anti-pertussis antibody among medical staff was heterogeneous, suggesting that this group could be at high risk for pertussis. Judgments made using BA antibody or anti-PA antibody results differ, and thus careful evaluation of anti-pertussis antibody titers is necessary. Prompt and accurate diagnostic tools are crucial for infection control in the hospital setting.

Authors+Show Affiliations

Infection Control Team, Ryukyu University Hospital, Okinawa 903-0215, Japan. fhiga@med.u-ryukyu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18806344

Citation

Higa, Futoshi, et al. "Assessment of Serum anti-Bordetella Pertussis Antibody Titers Among Medical Staff Members." Japanese Journal of Infectious Diseases, vol. 61, no. 5, 2008, pp. 371-4.
Higa F, Haranaga S, Tateyama M, et al. Assessment of serum anti-Bordetella pertussis antibody titers among medical staff members. Jpn J Infect Dis. 2008;61(5):371-4.
Higa, F., Haranaga, S., Tateyama, M., Hibiya, K., Yamashiro, T., Nakamatsu, M., Tomoyose, T., Nagahama, M., Okamura, T., Owan, T., Kuda, T., Kinjo, F., & Fujita, J. (2008). Assessment of serum anti-Bordetella pertussis antibody titers among medical staff members. Japanese Journal of Infectious Diseases, 61(5), 371-4.
Higa F, et al. Assessment of Serum anti-Bordetella Pertussis Antibody Titers Among Medical Staff Members. Jpn J Infect Dis. 2008;61(5):371-4. PubMed PMID: 18806344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of serum anti-Bordetella pertussis antibody titers among medical staff members. AU - Higa,Futoshi, AU - Haranaga,Syusaku, AU - Tateyama,Masao, AU - Hibiya,Kenji, AU - Yamashiro,Tsuyoshi, AU - Nakamatsu,Miyuki, AU - Tomoyose,Takeaki, AU - Nagahama,Masayoshi, AU - Okamura,Takayuki, AU - Owan,Tomoko, AU - Kuda,Tomoharu, AU - Kinjo,Fukunori, AU - Fujita,Jiro, PY - 2008/9/23/pubmed PY - 2008/10/28/medline PY - 2008/9/23/entrez SP - 371 EP - 4 JF - Japanese journal of infectious diseases JO - Jpn J Infect Dis VL - 61 IS - 5 N2 - This study comparatively evaluated the titers of the bacterial agglutination (BA) antibody for Bordetella pertussis, anti-pertussis toxin (PT) antibody, and anti-filamentous hemagglutinin (FHA) antibody in the serum of medical staff members. The geometric means of the anti-PT and anti-FHA antibody titers were 5.83 and 17.17 EU/mL, respectively. The positive rates of the BA antibodies against Tohama and Yamaguchi strains (> or = 40x), and anti-PT and anti-FHA antibodies (>10 EU/mL) were 81.3, 72.9, 43.8, and 68.8%, respectively. A high anti-PT antibody titer (>94 EU/mL) was found in 1 staff member, but this individual had no recent respiratory symptoms. The titers of the BA antibody against the Yamaguchi strain were weakly associated with the anti-PT antibody titers, but the BA antibody titer was not useful for predicting anti-PT antibody positivity. The seroprevalence of anti-pertussis antibody among medical staff was heterogeneous, suggesting that this group could be at high risk for pertussis. Judgments made using BA antibody or anti-PA antibody results differ, and thus careful evaluation of anti-pertussis antibody titers is necessary. Prompt and accurate diagnostic tools are crucial for infection control in the hospital setting. SN - 1344-6304 UR - https://www.unboundmedicine.com/medline/citation/18806344/Assessment_of_serum_anti_Bordetella_pertussis_antibody_titers_among_medical_staff_members_ L2 - https://medlineplus.gov/whoopingcough.html DB - PRIME DP - Unbound Medicine ER -