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Genetic characterization of Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in Bangladesh.
Jpn J Infect Dis. 2008 Sep; 61(5):393-6.JJ

Abstract

To assess the spread and genetic characteristics of Panton-Valentine leukocidin (PVL) gene-carrying Staphylococcus aureus in Bangladesh, we investigated 59 strains (49 isolates from clinical specimens and 10 isolates colonized in the nasal cavities of medical staff), including 26 methicillin-resistant S. aureus (MRSA) strains. The PVL gene was detected only in methicillin-susceptible S. aureus (MSSA) strains (7 clinical strains and 2 colonizing strains). PVL gene-positive MSSA strains were found to belong to coagulase serotypes III or VI and were classified into sequence types ST88 (CC88), ST772, and ST573 (CC1) by multilocus sequence typing, and agr types 2 or 3. These types were different from those determined for MRSA (coagulase serotypes I and IV, ST240 and ST361, and agr type 1). PVL gene-positive MSSA possessed a larger number of virulence factor genes than MRSA, although they were susceptible to more antimicrobials. These findings suggest that the PVL gene is distributed to limited populations of S. aureus clones with specific genetic traits that are distinct from MRSA in Bangladesh, but genetically close to CA-MRSA clones in the CC1 lineage reported in the United States and European countries.

Authors+Show Affiliations

Department of Microbiology, Sir Salimullah Medical College, Dhaka, Bangladesh.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18806351

Citation

Afroz, Sadia, et al. "Genetic Characterization of Staphylococcus Aureus Isolates Carrying Panton-Valentine Leukocidin Genes in Bangladesh." Japanese Journal of Infectious Diseases, vol. 61, no. 5, 2008, pp. 393-6.
Afroz S, Kobayashi N, Nagashima S, et al. Genetic characterization of Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in Bangladesh. Jpn J Infect Dis. 2008;61(5):393-6.
Afroz, S., Kobayashi, N., Nagashima, S., Alam, M. M., Hossain, A. B., Rahman, M. A., Islam, M. R., Lutfor, A. B., Muazzam, N., Khan, M. A., Paul, S. K., Shamsuzzaman, A. K., Mahmud, M. C., Musa, A. K., & Hossain, M. A. (2008). Genetic characterization of Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in Bangladesh. Japanese Journal of Infectious Diseases, 61(5), 393-6.
Afroz S, et al. Genetic Characterization of Staphylococcus Aureus Isolates Carrying Panton-Valentine Leukocidin Genes in Bangladesh. Jpn J Infect Dis. 2008;61(5):393-6. PubMed PMID: 18806351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic characterization of Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in Bangladesh. AU - Afroz,Sadia, AU - Kobayashi,Nobumichi, AU - Nagashima,Shigeo, AU - Alam,M Mahbub, AU - Hossain,A B M Bayezid, AU - Rahman,M Abdur, AU - Islam,M Rafiqul, AU - Lutfor,Afzalunnessa Binte, AU - Muazzam,Naima, AU - Khan,M Abul Hossain, AU - Paul,Shyamal Kumar, AU - Shamsuzzaman,A K M, AU - Mahmud,M Chan, AU - Musa,A K M, AU - Hossain,M Akram, PY - 2008/9/23/pubmed PY - 2008/10/28/medline PY - 2008/9/23/entrez SP - 393 EP - 6 JF - Japanese journal of infectious diseases JO - Jpn J Infect Dis VL - 61 IS - 5 N2 - To assess the spread and genetic characteristics of Panton-Valentine leukocidin (PVL) gene-carrying Staphylococcus aureus in Bangladesh, we investigated 59 strains (49 isolates from clinical specimens and 10 isolates colonized in the nasal cavities of medical staff), including 26 methicillin-resistant S. aureus (MRSA) strains. The PVL gene was detected only in methicillin-susceptible S. aureus (MSSA) strains (7 clinical strains and 2 colonizing strains). PVL gene-positive MSSA strains were found to belong to coagulase serotypes III or VI and were classified into sequence types ST88 (CC88), ST772, and ST573 (CC1) by multilocus sequence typing, and agr types 2 or 3. These types were different from those determined for MRSA (coagulase serotypes I and IV, ST240 and ST361, and agr type 1). PVL gene-positive MSSA possessed a larger number of virulence factor genes than MRSA, although they were susceptible to more antimicrobials. These findings suggest that the PVL gene is distributed to limited populations of S. aureus clones with specific genetic traits that are distinct from MRSA in Bangladesh, but genetically close to CA-MRSA clones in the CC1 lineage reported in the United States and European countries. SN - 1344-6304 UR - https://www.unboundmedicine.com/medline/citation/18806351/Genetic_characterization_of_Staphylococcus_aureus_isolates_carrying_Panton_Valentine_leukocidin_genes_in_Bangladesh_ L2 - https://medlineplus.gov/staphylococcalinfections.html DB - PRIME DP - Unbound Medicine ER -