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Understanding why probiotic therapies can be effective in treating IBD.
J Clin Gastroenterol 2008; 42 Suppl 3 Pt 1:S111-5JC

Abstract

Probiotics, for the treatment of inflammatory bowel disease, are a group of specific nonpathogenic bacteria that are functionally and genetically defined by their ability to reduce inflammation in the intestine. Although probiotics also seem to have broad beneficial effects in humans, both as a food and as a therapeutic agent, there are specific identified mechanisms in some, but not all, of these bacteria that are important relative to the pathogenesis of inflammatory bowel disease. Recently, studies relative to the mechanism of action of probiotics have identified that these organisms can have a direct effect on epithelial cell function and intestinal health, including enhancing epithelial barrier function, modulating epithelial cytokine secretion into an anti-inflammatory dominant profile, altering mucus production, changing bacterial luminal flora, modifying the innate and systemic immune system, and inducing regulatory T-cell effects. For probiotics to have a therapeutic role in the management of clinical inflammatory bowel disease, their therapeutic mechanism of action must be aligned with the pathogenic mechanism of action of the disease. In this regard, the role of probiotics for the clinical treatment of inflammatory bowel disease is emerging as the mechanisms and pathogenesis are being unraveled. It remains clear that probiotics are able to reduce gastrointestinal inflammation by exerting positive effects on epithelial cell and mucosal immune dysfunction.

Authors+Show Affiliations

Centre of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR), University of Alberta, Alberta, Edmonton, Canada. richard.fedorak@ualberta.ca

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18806699

Citation

Fedorak, Richard N.. "Understanding Why Probiotic Therapies Can Be Effective in Treating IBD." Journal of Clinical Gastroenterology, vol. 42 Suppl 3 Pt 1, 2008, pp. S111-5.
Fedorak RN. Understanding why probiotic therapies can be effective in treating IBD. J Clin Gastroenterol. 2008;42 Suppl 3 Pt 1:S111-5.
Fedorak, R. N. (2008). Understanding why probiotic therapies can be effective in treating IBD. Journal of Clinical Gastroenterology, 42 Suppl 3 Pt 1, pp. S111-5. doi:10.1097/MCG.0b013e31816d922c.
Fedorak RN. Understanding Why Probiotic Therapies Can Be Effective in Treating IBD. J Clin Gastroenterol. 2008;42 Suppl 3 Pt 1:S111-5. PubMed PMID: 18806699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding why probiotic therapies can be effective in treating IBD. A1 - Fedorak,Richard N, PY - 2008/10/1/pubmed PY - 2008/12/17/medline PY - 2008/10/1/entrez SP - S111 EP - 5 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 42 Suppl 3 Pt 1 N2 - Probiotics, for the treatment of inflammatory bowel disease, are a group of specific nonpathogenic bacteria that are functionally and genetically defined by their ability to reduce inflammation in the intestine. Although probiotics also seem to have broad beneficial effects in humans, both as a food and as a therapeutic agent, there are specific identified mechanisms in some, but not all, of these bacteria that are important relative to the pathogenesis of inflammatory bowel disease. Recently, studies relative to the mechanism of action of probiotics have identified that these organisms can have a direct effect on epithelial cell function and intestinal health, including enhancing epithelial barrier function, modulating epithelial cytokine secretion into an anti-inflammatory dominant profile, altering mucus production, changing bacterial luminal flora, modifying the innate and systemic immune system, and inducing regulatory T-cell effects. For probiotics to have a therapeutic role in the management of clinical inflammatory bowel disease, their therapeutic mechanism of action must be aligned with the pathogenic mechanism of action of the disease. In this regard, the role of probiotics for the clinical treatment of inflammatory bowel disease is emerging as the mechanisms and pathogenesis are being unraveled. It remains clear that probiotics are able to reduce gastrointestinal inflammation by exerting positive effects on epithelial cell and mucosal immune dysfunction. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/18806699/Understanding_why_probiotic_therapies_can_be_effective_in_treating_IBD_ L2 - http://Insights.ovid.com/pubmed?pmid=18806699 DB - PRIME DP - Unbound Medicine ER -