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Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats.
Methods Find Exp Clin Pharmacol. 2008 Jun; 30(5):355-62.MF

Abstract

The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activities were assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Both types of extracts were prepared in concentrations of 10%, 50% and 100% by serial dilution in distilled water or dimethyl sulfoxide, respectively, and were administered subcutaneously 30 min prior to each test. Except for the 10% aqueous extract which exhibits activity only in the early phase, the extracts were found to exhibit significant (P < 0.05) activity in the early and late phases of the formalin test. Furthermore, the aqueous and lipid-based extracts were also found to show significant (P < 0.05) antiinflammatory activity, with the former showing a greater effect at the lowest concentration used. The lipidbased, but not the aqueous, extract was found to have significant (P < 0.05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities.

Authors+Show Affiliations

Faculty of Pharmacy, Science and Technology Complex, Universiti Teknologi MARA, Shah Alam, Malaysia. shaza8174@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18806894

Citation

Zakaria, Z A., et al. "Antinociceptive, Antiinflammatory and Antipyretic Properties of Channa Striatus Fillet Aqueous and Lipid-based Extracts in Rats." Methods and Findings in Experimental and Clinical Pharmacology, vol. 30, no. 5, 2008, pp. 355-62.
Zakaria ZA, Kumar GH, Mat Jais AM, et al. Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats. Methods Find Exp Clin Pharmacol. 2008;30(5):355-62.
Zakaria, Z. A., Kumar, G. H., Mat Jais, A. M., Sulaiman, M. R., & Somchit, M. N. (2008). Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats. Methods and Findings in Experimental and Clinical Pharmacology, 30(5), 355-62. https://doi.org/10.1358/mf.2008.30.5.1186084
Zakaria ZA, et al. Antinociceptive, Antiinflammatory and Antipyretic Properties of Channa Striatus Fillet Aqueous and Lipid-based Extracts in Rats. Methods Find Exp Clin Pharmacol. 2008;30(5):355-62. PubMed PMID: 18806894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats. AU - Zakaria,Z A, AU - Kumar,G Hanan, AU - Mat Jais,A M, AU - Sulaiman,M R, AU - Somchit,M N, PY - 2008/9/23/pubmed PY - 2009/1/7/medline PY - 2008/9/23/entrez SP - 355 EP - 62 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 30 IS - 5 N2 - The present study was carried out to elucidate the antinociceptive, antiinflammatory and antipyretic properties of the aqueous and lipid-based extracts of Channa striatus fillet in rats. The antinociceptive activity was assessed using the formalin test, and the antiinflammatory and antipyretic activities were assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Both types of extracts were prepared in concentrations of 10%, 50% and 100% by serial dilution in distilled water or dimethyl sulfoxide, respectively, and were administered subcutaneously 30 min prior to each test. Except for the 10% aqueous extract which exhibits activity only in the early phase, the extracts were found to exhibit significant (P < 0.05) activity in the early and late phases of the formalin test. Furthermore, the aqueous and lipid-based extracts were also found to show significant (P < 0.05) antiinflammatory activity, with the former showing a greater effect at the lowest concentration used. The lipidbased, but not the aqueous, extract was found to have significant (P < 0.05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/18806894/Antinociceptive_antiinflammatory_and_antipyretic_properties_of_Channa_striatus_fillet_aqueous_and_lipid_based_extracts_in_rats_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=6&amp;p_RefId=1186084 DB - PRIME DP - Unbound Medicine ER -