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Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans.
Psychopharmacology (Berl) 2009; 202(4):569-78P

Abstract

BACKGROUND

Acute and chronic exposure to cannabinoids has been associated with cognitive deficits, a higher risk for schizophrenia and other drug abuse. However, the precise mechanism underlying such effects is not known. Preclinical studies suggest that cannabinoids modulate brain-derived neurotrophic factor (BDNF). Accordingly, we hypothesized that Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the principal active component of cannabis, would alter BDNF levels in humans.

MATERIALS AND METHODS

Healthy control subjects (n = 14) and light users of cannabis (n = 9) received intravenous administration of (0.0286 mg/kg) Delta(9)-THC in a double-blind, fixed order, placebo-controlled, laboratory study. Serum sampled at baseline, after placebo administration, and after Delta(9)-THC administration was assayed for BDNF using ELISA.

RESULTS

Delta(9)-THC increased serum BDNF levels in healthy controls but not light users of cannabis. Further, light users of cannabis had lower basal BDNF levels. Delta(9)-THC produced psychotomimetic effects, perceptual alterations, and "high" and spatial memory impairments.

IMPLICATIONS

The effects of socially relevant doses of cannabinoids on BDNF suggest a possible mechanism underlying the consequences of exposure to cannabis. This may be of particular importance for the developing brain and also in disorders believed to involve altered neurodevelopment such as schizophrenia. Larger studies to investigate the effects of cannabinoids on BDNF and other neurotrophins are warranted.

Authors+Show Affiliations

Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. deepak.dsouza@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18807247

Citation

D'Souza, Deepak Cyril, et al. "Preliminary Evidence of Cannabinoid Effects On Brain-derived Neurotrophic Factor (BDNF) Levels in Humans." Psychopharmacology, vol. 202, no. 4, 2009, pp. 569-78.
D'Souza DC, Pittman B, Perry E, et al. Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology (Berl). 2009;202(4):569-78.
D'Souza, D. C., Pittman, B., Perry, E., & Simen, A. (2009). Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology, 202(4), pp. 569-78. doi:10.1007/s00213-008-1333-2.
D'Souza DC, et al. Preliminary Evidence of Cannabinoid Effects On Brain-derived Neurotrophic Factor (BDNF) Levels in Humans. Psychopharmacology (Berl). 2009;202(4):569-78. PubMed PMID: 18807247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. AU - D'Souza,Deepak Cyril, AU - Pittman,Brian, AU - Perry,Edward, AU - Simen,Arthur, Y1 - 2008/09/21/ PY - 2008/04/15/received PY - 2008/09/01/accepted PY - 2008/9/23/pubmed PY - 2009/8/12/medline PY - 2008/9/23/entrez SP - 569 EP - 78 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 202 IS - 4 N2 - BACKGROUND: Acute and chronic exposure to cannabinoids has been associated with cognitive deficits, a higher risk for schizophrenia and other drug abuse. However, the precise mechanism underlying such effects is not known. Preclinical studies suggest that cannabinoids modulate brain-derived neurotrophic factor (BDNF). Accordingly, we hypothesized that Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the principal active component of cannabis, would alter BDNF levels in humans. MATERIALS AND METHODS: Healthy control subjects (n = 14) and light users of cannabis (n = 9) received intravenous administration of (0.0286 mg/kg) Delta(9)-THC in a double-blind, fixed order, placebo-controlled, laboratory study. Serum sampled at baseline, after placebo administration, and after Delta(9)-THC administration was assayed for BDNF using ELISA. RESULTS: Delta(9)-THC increased serum BDNF levels in healthy controls but not light users of cannabis. Further, light users of cannabis had lower basal BDNF levels. Delta(9)-THC produced psychotomimetic effects, perceptual alterations, and "high" and spatial memory impairments. IMPLICATIONS: The effects of socially relevant doses of cannabinoids on BDNF suggest a possible mechanism underlying the consequences of exposure to cannabis. This may be of particular importance for the developing brain and also in disorders believed to involve altered neurodevelopment such as schizophrenia. Larger studies to investigate the effects of cannabinoids on BDNF and other neurotrophins are warranted. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/18807247/Preliminary_evidence_of_cannabinoid_effects_on_brain_derived_neurotrophic_factor__BDNF__levels_in_humans_ L2 - https://dx.doi.org/10.1007/s00213-008-1333-2 DB - PRIME DP - Unbound Medicine ER -