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Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats.
Indian J Exp Biol. 2008 Jul; 46(7):528-33.IJ

Abstract

Effect of methanolic extract of fruits of P. longum (PLM) on the biochemical changes, tissue peroxidative damage and abnormal antioxidant levels in adriamycin (ADR) induced cardiotoxicity in Wistar rats was investigated. PLM was administered to Wistar albino rats in two different doses, by gastric gavage (250 mg/kg and 500 mg/kg) for 21 days followed by ip ADR (15 mg/kg) on 21st day. ADR administration showed significant decrease in the activities of marker enzymes aspartate transaminase, alanine transaminase, lactate dehydrogenase and creatine kinase in heart with a concomitant increase in their activities in serum. A significant increase in lipid peroxide levels in heart of ADR treated rats was also observed. Pretreatment with PLM ameliorated the effect of ADR on lipid peroxide formation and restored activities of marker enzymes. Activities of myocardial antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase along with reduced glutathione were significantly lowered due to cardiotoxicity in rats administered with ADR. PLM pretreatment augmented these endogenous antioxidants. Histopathological studies of heart revealed degenerative changes and cellular infiltrations in rats administered with ADR and pretreatment with PLM reduced the intensity of such lesions. The results indicate that PLM administration offers significant protection against ADR induced oxidative stress and reduces the cardiotoxicity by virtue of its antioxidant activity.

Authors+Show Affiliations

Department of Pharmaceutical Sciences and Technology, Mumbai University Institute of Chemical Technology Nathalal Parikh Marg, Matunga, Mumbai 400 019, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18807757

Citation

Wakade, Alok S., et al. "Protective Effect of Piper Longum L. On Oxidative Stress Induced Injury and Cellular Abnormality in Adriamycin Induced Cardiotoxicity in Rats." Indian Journal of Experimental Biology, vol. 46, no. 7, 2008, pp. 528-33.
Wakade AS, Shah AS, Kulkarni MP, et al. Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats. Indian J Exp Biol. 2008;46(7):528-33.
Wakade, A. S., Shah, A. S., Kulkarni, M. P., & Juvekar, A. R. (2008). Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats. Indian Journal of Experimental Biology, 46(7), 528-33.
Wakade AS, et al. Protective Effect of Piper Longum L. On Oxidative Stress Induced Injury and Cellular Abnormality in Adriamycin Induced Cardiotoxicity in Rats. Indian J Exp Biol. 2008;46(7):528-33. PubMed PMID: 18807757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Piper longum L. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats. AU - Wakade,Alok S, AU - Shah,Abhishek S, AU - Kulkarni,Mrugaya P, AU - Juvekar,Archana R, PY - 2008/9/24/pubmed PY - 2009/6/24/medline PY - 2008/9/24/entrez SP - 528 EP - 33 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 46 IS - 7 N2 - Effect of methanolic extract of fruits of P. longum (PLM) on the biochemical changes, tissue peroxidative damage and abnormal antioxidant levels in adriamycin (ADR) induced cardiotoxicity in Wistar rats was investigated. PLM was administered to Wistar albino rats in two different doses, by gastric gavage (250 mg/kg and 500 mg/kg) for 21 days followed by ip ADR (15 mg/kg) on 21st day. ADR administration showed significant decrease in the activities of marker enzymes aspartate transaminase, alanine transaminase, lactate dehydrogenase and creatine kinase in heart with a concomitant increase in their activities in serum. A significant increase in lipid peroxide levels in heart of ADR treated rats was also observed. Pretreatment with PLM ameliorated the effect of ADR on lipid peroxide formation and restored activities of marker enzymes. Activities of myocardial antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase along with reduced glutathione were significantly lowered due to cardiotoxicity in rats administered with ADR. PLM pretreatment augmented these endogenous antioxidants. Histopathological studies of heart revealed degenerative changes and cellular infiltrations in rats administered with ADR and pretreatment with PLM reduced the intensity of such lesions. The results indicate that PLM administration offers significant protection against ADR induced oxidative stress and reduces the cardiotoxicity by virtue of its antioxidant activity. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/18807757/Protective_effect_of_Piper_longum_L__on_oxidative_stress_induced_injury_and_cellular_abnormality_in_adriamycin_induced_cardiotoxicity_in_rats_ L2 - https://medlineplus.gov/heartdiseases.html DB - PRIME DP - Unbound Medicine ER -