Tags

Type your tag names separated by a space and hit enter

COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life.
Acta Psychiatr Scand. 2009 Feb; 119(2):156-60.AP

Abstract

OBJECTIVE

A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted.

METHOD

The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (n = 31) and healthy controls (n = 25).

RESULTS

Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability.

CONCLUSION

The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life.

Authors+Show Affiliations

Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands. cecile.henquet@sp.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18808401

Citation

Henquet, C, et al. "COMT ValMet Moderation of Cannabis-induced Psychosis: a Momentary Assessment Study of 'switching On' Hallucinations in the Flow of Daily Life." Acta Psychiatrica Scandinavica, vol. 119, no. 2, 2009, pp. 156-60.
Henquet C, Rosa A, Delespaul P, et al. COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life. Acta Psychiatr Scand. 2009;119(2):156-60.
Henquet, C., Rosa, A., Delespaul, P., Papiol, S., Fananás, L., van Os, J., & Myin-Germeys, I. (2009). COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life. Acta Psychiatrica Scandinavica, 119(2), 156-60. https://doi.org/10.1111/j.1600-0447.2008.01265.x
Henquet C, et al. COMT ValMet Moderation of Cannabis-induced Psychosis: a Momentary Assessment Study of 'switching On' Hallucinations in the Flow of Daily Life. Acta Psychiatr Scand. 2009;119(2):156-60. PubMed PMID: 18808401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life. AU - Henquet,C, AU - Rosa,A, AU - Delespaul,P, AU - Papiol,S, AU - Fananás,L, AU - van Os,J, AU - Myin-Germeys,I, Y1 - 2008/09/18/ PY - 2008/9/24/pubmed PY - 2009/4/16/medline PY - 2008/9/24/entrez SP - 156 EP - 60 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 119 IS - 2 N2 - OBJECTIVE: A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted. METHOD: The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (n = 31) and healthy controls (n = 25). RESULTS: Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability. CONCLUSION: The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life. SN - 1600-0447 UR - https://www.unboundmedicine.com/medline/citation/18808401/COMT_ValMet_moderation_of_cannabis_induced_psychosis:_a_momentary_assessment_study_of_'switching_on'_hallucinations_in_the_flow_of_daily_life_ L2 - https://doi.org/10.1111/j.1600-0447.2008.01265.x DB - PRIME DP - Unbound Medicine ER -