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L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes.
Int J Exp Pathol. 2008 Oct; 89(5):382-8.IJ

Abstract

It was previously shown that administration of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) aggravated murine viral myocarditis by increasing myocardial virus titres. Experimental autoimmune myocarditis in mice and rats mimics human fulminant myocarditis. The effects of L-arginine, a precursor of nitric oxide, upon heart failure in experimental autoimmune myocarditis were evaluated. Dietary L-arginine (L-arginine group) and L-arginine plus N(G)-nitro-L-arginine methyl ester (L-arginine + l-NAME group) were administered to C57BL/6 mice immunized with porcine cardiac myosin over 3 weeks. An untreated myocarditis group was prepared. Cardiac damage was less in the L-arginine group compared with the other two groups, as was incidence of heart failure. In addition, extracellular matrix change was less prominent in the L-arginine group. Plasma concentrations of nitric oxide were elevated in the L-arginine group. Cytotoxic activities of lymphocytes were lower in L-arginine group than in other two groups. L-arginine treatment may be effective in preventing the development of heart failure in experimental myocarditis by maintaining extracellular matrix and reducing the cytotoxic activity of lymphocytes.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18808530

Citation

Okabe, Taka-aki, et al. "L-arginine Ameliorates Experimental Autoimmune Myocarditis By Maintaining Extracellular Matrix and Reducing Cytotoxic Activity of Lymphocytes." International Journal of Experimental Pathology, vol. 89, no. 5, 2008, pp. 382-8.
Okabe TA, Hattori M, Yuan Z, et al. L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes. Int J Exp Pathol. 2008;89(5):382-8.
Okabe, T. A., Hattori, M., Yuan, Z., & Kishimoto, C. (2008). L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes. International Journal of Experimental Pathology, 89(5), 382-8. https://doi.org/10.1111/j.1365-2613.2008.00609.x
Okabe TA, et al. L-arginine Ameliorates Experimental Autoimmune Myocarditis By Maintaining Extracellular Matrix and Reducing Cytotoxic Activity of Lymphocytes. Int J Exp Pathol. 2008;89(5):382-8. PubMed PMID: 18808530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes. AU - Okabe,Taka-aki, AU - Hattori,Miki, AU - Yuan,Zuyi, AU - Kishimoto,Chiharu, PY - 2008/9/24/pubmed PY - 2008/12/17/medline PY - 2008/9/24/entrez SP - 382 EP - 8 JF - International journal of experimental pathology JO - Int J Exp Pathol VL - 89 IS - 5 N2 - It was previously shown that administration of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) aggravated murine viral myocarditis by increasing myocardial virus titres. Experimental autoimmune myocarditis in mice and rats mimics human fulminant myocarditis. The effects of L-arginine, a precursor of nitric oxide, upon heart failure in experimental autoimmune myocarditis were evaluated. Dietary L-arginine (L-arginine group) and L-arginine plus N(G)-nitro-L-arginine methyl ester (L-arginine + l-NAME group) were administered to C57BL/6 mice immunized with porcine cardiac myosin over 3 weeks. An untreated myocarditis group was prepared. Cardiac damage was less in the L-arginine group compared with the other two groups, as was incidence of heart failure. In addition, extracellular matrix change was less prominent in the L-arginine group. Plasma concentrations of nitric oxide were elevated in the L-arginine group. Cytotoxic activities of lymphocytes were lower in L-arginine group than in other two groups. L-arginine treatment may be effective in preventing the development of heart failure in experimental myocarditis by maintaining extracellular matrix and reducing the cytotoxic activity of lymphocytes. SN - 1365-2613 UR - https://www.unboundmedicine.com/medline/citation/18808530/L_arginine_ameliorates_experimental_autoimmune_myocarditis_by_maintaining_extracellular_matrix_and_reducing_cytotoxic_activity_of_lymphocytes_ L2 - https://doi.org/10.1111/j.1365-2613.2008.00609.x DB - PRIME DP - Unbound Medicine ER -