Tags

Type your tag names separated by a space and hit enter

The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria.
BMC Gastroenterol 2008; 8:43BG

Abstract

BACKGROUND

Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). To date, no surveys have been performed to investigate the clinical overlap between these two disorders using Rome III criteria. Our aim was to investigate the prevalence and risk factors for the overlap of FD and IBS based on Rome III criteria in a large clinical sample.

METHODS

Consecutive patients at the general gastroenterology outpatient clinic were requested to complete a self-report questionnaire. FD and IBS were defined by Rome III criteria.

RESULTS

Questionnaires were returned by 3014 patients (52.8% female, 89% response rate). FD-IBS overlap was observed in 5.0% of the patients, while 15.2% and 10.9% of the patients were classified as FD alone and IBS alone, respectively. Compared with non-IBS patients, the odds ratio of having FD among IBS patients was 2.09 (95% CI: 1.68-2.59). Patients with FD-IBS overlap had higher severity scores for the postprandial fullness symptom (2.35 +/- 1.49 vs. 1.72 +/- 1.59, P < 0.001) and overall FD symptom (6.65 +/- 2.88 vs. 5.82 +/- 2.76, P = 0.002) than those with FD alone. The only independent risk factor for FD-IBS overlap vs. FD alone was the presence of postprandial fullness symptom (OR 2.67, 95% CI: 1.34-5.31).

CONCLUSION

Clinical overlap of FD and IBS according to Rome III criteria is very common. One risk factor for FD-IBS overlap is the presence of postprandial fullness symptom. This study provides clues for future pathophysiological studies of FD and IBS.

Authors+Show Affiliations

Department of Gastroenterology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China. waj1103@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18808723

Citation

Wang, Anjiang, et al. "The Clinical Overlap Between Functional Dyspepsia and Irritable Bowel Syndrome Based On Rome III Criteria." BMC Gastroenterology, vol. 8, 2008, p. 43.
Wang A, Liao X, Xiong L, et al. The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria. BMC Gastroenterol. 2008;8:43.
Wang, A., Liao, X., Xiong, L., Peng, S., Xiao, Y., Liu, S., ... Chen, M. (2008). The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria. BMC Gastroenterology, 8, p. 43. doi:10.1186/1471-230X-8-43.
Wang A, et al. The Clinical Overlap Between Functional Dyspepsia and Irritable Bowel Syndrome Based On Rome III Criteria. BMC Gastroenterol. 2008 Sep 23;8:43. PubMed PMID: 18808723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria. AU - Wang,Anjiang, AU - Liao,XianHua, AU - Xiong,LiShou, AU - Peng,Sui, AU - Xiao,YingLian, AU - Liu,SiChun, AU - Hu,PinJin, AU - Chen,MinHu, Y1 - 2008/09/23/ PY - 2008/04/17/received PY - 2008/09/23/accepted PY - 2008/9/24/pubmed PY - 2008/12/17/medline PY - 2008/9/24/entrez SP - 43 EP - 43 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 8 N2 - BACKGROUND: Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). To date, no surveys have been performed to investigate the clinical overlap between these two disorders using Rome III criteria. Our aim was to investigate the prevalence and risk factors for the overlap of FD and IBS based on Rome III criteria in a large clinical sample. METHODS: Consecutive patients at the general gastroenterology outpatient clinic were requested to complete a self-report questionnaire. FD and IBS were defined by Rome III criteria. RESULTS: Questionnaires were returned by 3014 patients (52.8% female, 89% response rate). FD-IBS overlap was observed in 5.0% of the patients, while 15.2% and 10.9% of the patients were classified as FD alone and IBS alone, respectively. Compared with non-IBS patients, the odds ratio of having FD among IBS patients was 2.09 (95% CI: 1.68-2.59). Patients with FD-IBS overlap had higher severity scores for the postprandial fullness symptom (2.35 +/- 1.49 vs. 1.72 +/- 1.59, P < 0.001) and overall FD symptom (6.65 +/- 2.88 vs. 5.82 +/- 2.76, P = 0.002) than those with FD alone. The only independent risk factor for FD-IBS overlap vs. FD alone was the presence of postprandial fullness symptom (OR 2.67, 95% CI: 1.34-5.31). CONCLUSION: Clinical overlap of FD and IBS according to Rome III criteria is very common. One risk factor for FD-IBS overlap is the presence of postprandial fullness symptom. This study provides clues for future pathophysiological studies of FD and IBS. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/18808723/The_clinical_overlap_between_functional_dyspepsia_and_irritable_bowel_syndrome_based_on_Rome_III_criteria_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-8-43 DB - PRIME DP - Unbound Medicine ER -