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[Autoimmune limbic encephalitis with anti-NMDA receptor antibodies and ovarian teratoma: a treatable form of paraneoplastic limbic encephalitis].
Rev Neurol (Paris). 2009 Jan; 165(1):70-5.RN

Abstract

INTRODUCTION

The first French-language case of limbic encephalitis due to anti-N-methyl-D-aspartate receptor to glutamate (NMDA-R) antibodies associated with an ovarian teratoma is reported.

CLINICAL CASE

A 35-year-old woman presented with a subacute severe anterograde memory deficit, psychiatric disturbances and generalized seizures associated with an ovarian teratoma. No abnormality was noticed on the two successive MRI. The cerebrospinal fluid showed mild lymphocytosis and elevation of protein concentration. The search for classical onconeuronal antibodies in the serum was negative. Total body computed tomographic scan disclosed a five centimeter long ovarian cyst. Pathology found an ovarian teratoma containing a small immature neuroepithelial component. Complete tumor resection associated with high doses of intravenous methylprednisolone and intravenous polyvalent immunoglobulins allowed her clinical state to improve as soon as three days after surgery. Full recovery was noted four months later. Serum anti-NMDA-R antibodies were positive.

CONCLUSION

Owing to the recent description of the association between anti-NMDA-R and limbic encephalitis and the frequent good prognosis reported in the available series and case reports, it is important to search for this association in the not so rare cases of limbic encephalitis when no other cause is disclosed.

Authors+Show Affiliations

Service de neurologie, hôpital Delafontaine, 2, rue Pierre-Delafontaine, 93200 Saint-Denis, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

18809188

Citation

Henry, C, et al. "[Autoimmune Limbic Encephalitis With anti-NMDA Receptor Antibodies and Ovarian Teratoma: a Treatable Form of Paraneoplastic Limbic Encephalitis]." Revue Neurologique, vol. 165, no. 1, 2009, pp. 70-5.
Henry C, Husson H, de Broucker T. [Autoimmune limbic encephalitis with anti-NMDA receptor antibodies and ovarian teratoma: a treatable form of paraneoplastic limbic encephalitis]. Rev Neurol (Paris). 2009;165(1):70-5.
Henry, C., Husson, H., & de Broucker, T. (2009). [Autoimmune limbic encephalitis with anti-NMDA receptor antibodies and ovarian teratoma: a treatable form of paraneoplastic limbic encephalitis]. Revue Neurologique, 165(1), 70-5. https://doi.org/10.1016/j.neurol.2008.07.020
Henry C, Husson H, de Broucker T. [Autoimmune Limbic Encephalitis With anti-NMDA Receptor Antibodies and Ovarian Teratoma: a Treatable Form of Paraneoplastic Limbic Encephalitis]. Rev Neurol (Paris). 2009;165(1):70-5. PubMed PMID: 18809188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Autoimmune limbic encephalitis with anti-NMDA receptor antibodies and ovarian teratoma: a treatable form of paraneoplastic limbic encephalitis]. AU - Henry,C, AU - Husson,H, AU - de Broucker,T, Y1 - 2008/09/21/ PY - 2008/06/10/received PY - 2008/06/25/revised PY - 2008/07/02/accepted PY - 2008/9/24/pubmed PY - 2009/3/21/medline PY - 2008/9/24/entrez SP - 70 EP - 5 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 165 IS - 1 N2 - INTRODUCTION: The first French-language case of limbic encephalitis due to anti-N-methyl-D-aspartate receptor to glutamate (NMDA-R) antibodies associated with an ovarian teratoma is reported. CLINICAL CASE: A 35-year-old woman presented with a subacute severe anterograde memory deficit, psychiatric disturbances and generalized seizures associated with an ovarian teratoma. No abnormality was noticed on the two successive MRI. The cerebrospinal fluid showed mild lymphocytosis and elevation of protein concentration. The search for classical onconeuronal antibodies in the serum was negative. Total body computed tomographic scan disclosed a five centimeter long ovarian cyst. Pathology found an ovarian teratoma containing a small immature neuroepithelial component. Complete tumor resection associated with high doses of intravenous methylprednisolone and intravenous polyvalent immunoglobulins allowed her clinical state to improve as soon as three days after surgery. Full recovery was noted four months later. Serum anti-NMDA-R antibodies were positive. CONCLUSION: Owing to the recent description of the association between anti-NMDA-R and limbic encephalitis and the frequent good prognosis reported in the available series and case reports, it is important to search for this association in the not so rare cases of limbic encephalitis when no other cause is disclosed. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/18809188/[Autoimmune_limbic_encephalitis_with_anti_NMDA_receptor_antibodies_and_ovarian_teratoma:_a_treatable_form_of_paraneoplastic_limbic_encephalitis]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-3787(08)00475-X DB - PRIME DP - Unbound Medicine ER -