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Heat shock effect upon dengue virus replication into U937 cells.
Virus Res. 2008 Dec; 138(1-2):111-8.VR

Abstract

The molecules involved in dengue virus entry into human cells are currently unknown. We have previously shown that two surface heat shock proteins (Hsps), Hsp90 and Hsp70 are part of a receptor complex in monocytic cells. In the present report, the effect of heat shock (HS) on dengue virus infection is analyzed. We have documented a more than twofold increase in dengue virus infectivity after HS treatment in monocytic cells U937; this effect correlates mainly with an increase in viral entry due to a major presence of both Hsps on the surface of monocytic cells, particularly in membrane microdomains. Interestingly, since heat shock treatment at 6h post-infection also increased viral yields, it is likely that HS also modulates positively dengue virus replication.

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Authors+Show Affiliations

Chavez-Salinas S
Departamento de Patología Experimental, Centro de Investigación y de Estudios Avanzados del IPN, Av. I.P.N. 2508, Col. San Pedro Zacatenco, México D.F. C.P. 07360, Mexico.
Ceballos-Olvera I
No affiliation info available
Reyes-Del Valle J
No affiliation info available
Medina F
No affiliation info available
Del Angel RM
No affiliation info available

MeSH

Cell MembraneDengueDengue VirusHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHeat-Shock ResponseHumansMonocytesU937 CellsVirus InternalizationVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18809444

Citation

Chavez-Salinas, Salvador, et al. "Heat Shock Effect Upon Dengue Virus Replication Into U937 Cells." Virus Research, vol. 138, no. 1-2, 2008, pp. 111-8.
Chavez-Salinas S, Ceballos-Olvera I, Reyes-Del Valle J, et al. Heat shock effect upon dengue virus replication into U937 cells. Virus Res. 2008;138(1-2):111-8.
Chavez-Salinas, S., Ceballos-Olvera, I., Reyes-Del Valle, J., Medina, F., & Del Angel, R. M. (2008). Heat shock effect upon dengue virus replication into U937 cells. Virus Research, 138(1-2), 111-8. https://doi.org/10.1016/j.virusres.2008.08.012
Chavez-Salinas S, et al. Heat Shock Effect Upon Dengue Virus Replication Into U937 Cells. Virus Res. 2008;138(1-2):111-8. PubMed PMID: 18809444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heat shock effect upon dengue virus replication into U937 cells. AU - Chavez-Salinas,Salvador, AU - Ceballos-Olvera,Ivonne, AU - Reyes-Del Valle,Jorge, AU - Medina,Fernando, AU - Del Angel,Rosa M, Y1 - 2008/10/07/ PY - 2008/04/05/received PY - 2008/08/26/revised PY - 2008/08/27/accepted PY - 2008/9/24/pubmed PY - 2009/1/30/medline PY - 2008/9/24/entrez SP - 111 EP - 8 JF - Virus research JO - Virus Res VL - 138 IS - 1-2 N2 - The molecules involved in dengue virus entry into human cells are currently unknown. We have previously shown that two surface heat shock proteins (Hsps), Hsp90 and Hsp70 are part of a receptor complex in monocytic cells. In the present report, the effect of heat shock (HS) on dengue virus infection is analyzed. We have documented a more than twofold increase in dengue virus infectivity after HS treatment in monocytic cells U937; this effect correlates mainly with an increase in viral entry due to a major presence of both Hsps on the surface of monocytic cells, particularly in membrane microdomains. Interestingly, since heat shock treatment at 6h post-infection also increased viral yields, it is likely that HS also modulates positively dengue virus replication. SN - 0168-1702 UR - https://www.unboundmedicine.com/medline/citation/18809444/Heat_shock_effect_upon_dengue_virus_replication_into_U937_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(08)00322-5 DB - PRIME DP - Unbound Medicine ER -