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Metabolic and hormonal effects of oral DHEA in premenopausal women with HIV infection: a randomized, prospective, placebo-controlled pilot study.
Horm Metab Res. 2009 Mar; 41(3):244-9.HM

Abstract

Women with HIV infection use dehydroepiandrosterone (DHEA) because of its potential effects on mood and energy. We examined the effects of DHEA on the hypothalamic-pituitary-adrenal and gonadal axes and on insulin sensitivity. Fifteen HIV-positive women were randomized to receive placebo (6 subjects) or oral DHEA (9 subjects). ACTH-, CRF-, and GnRH-stimulation tests were performed before and after 8 weeks of treatment. DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured. There was a significant increase in DHEA (p<0.004), DHEA-S (p<0.008), total testosterone (p<0.008), dihydrotestosterone (p<0.004), androstenedione (p<0.04), and estrone (p<0.03) from baseline within the DHEA group but not within the placebo group. There was a significant increase in DHEA (p<0.0006), DHEA-S (p<0.032), total testosterone (p<0.01), and dihydrotestosterone (p<0.005) in the DHEA group compared with the placebo group. Oral DHEA produces significant increases in circulating DHEA, DHEA-S, testosterone, DHT, and, possibly, androstenedione and estrone levels in premenopausal women with HIV infection. In the current pilot study these hormone changes did not affect the pituitary or adrenal axis or insulin/IGF indices. Long-term studies with larger groups of patients are needed to confirm these data and to determine their clinical significance.

Links

Publisher Full Text
ncbi.nlm.nih.gov
thieme-connect.com
PMC Free PDF

Authors+Show Affiliations

Poretsky L
Division of Endocrinology, Department of Medicine, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, USA. lporetsk@chpnet.org
Song L
No affiliation info available
Brillon DJ
No affiliation info available
Ferrando S
No affiliation info available
Chiu J
No affiliation info available
McElhiney M
No affiliation info available
Ferenczi A
No affiliation info available
Sison C
No affiliation info available
Haller I
No affiliation info available
Rabkin J
No affiliation info available

MeSH

Administration, OralAffectAndrostenedioneDehydroepiandrosteroneDihydrotestosteroneDouble-Blind MethodEnergy MetabolismEstroneFemaleHIV InfectionsHumansKineticsMood DisordersPilot ProjectsPlacebosPremenopauseTestosteroneTime Factors

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18810712

Citation

Poretsky, L, et al. "Metabolic and Hormonal Effects of Oral DHEA in Premenopausal Women With HIV Infection: a Randomized, Prospective, Placebo-controlled Pilot Study." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 41, no. 3, 2009, pp. 244-9.
Poretsky L, Song L, Brillon DJ, et al. Metabolic and hormonal effects of oral DHEA in premenopausal women with HIV infection: a randomized, prospective, placebo-controlled pilot study. Horm Metab Res. 2009;41(3):244-9.
Poretsky, L., Song, L., Brillon, D. J., Ferrando, S., Chiu, J., McElhiney, M., Ferenczi, A., Sison, C., Haller, I., & Rabkin, J. (2009). Metabolic and hormonal effects of oral DHEA in premenopausal women with HIV infection: a randomized, prospective, placebo-controlled pilot study. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 41(3), 244-9. https://doi.org/10.1055/s-0028-1087175
Poretsky L, et al. Metabolic and Hormonal Effects of Oral DHEA in Premenopausal Women With HIV Infection: a Randomized, Prospective, Placebo-controlled Pilot Study. Horm Metab Res. 2009;41(3):244-9. PubMed PMID: 18810712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic and hormonal effects of oral DHEA in premenopausal women with HIV infection: a randomized, prospective, placebo-controlled pilot study. AU - Poretsky,L, AU - Song,L, AU - Brillon,D J, AU - Ferrando,S, AU - Chiu,J, AU - McElhiney,M, AU - Ferenczi,A, AU - Sison,C, AU - Haller,I, AU - Rabkin,J, Y1 - 2008/09/22/ PY - 2008/9/24/pubmed PY - 2009/5/21/medline PY - 2008/9/24/entrez SP - 244 EP - 9 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 41 IS - 3 N2 - Women with HIV infection use dehydroepiandrosterone (DHEA) because of its potential effects on mood and energy. We examined the effects of DHEA on the hypothalamic-pituitary-adrenal and gonadal axes and on insulin sensitivity. Fifteen HIV-positive women were randomized to receive placebo (6 subjects) or oral DHEA (9 subjects). ACTH-, CRF-, and GnRH-stimulation tests were performed before and after 8 weeks of treatment. DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured. There was a significant increase in DHEA (p<0.004), DHEA-S (p<0.008), total testosterone (p<0.008), dihydrotestosterone (p<0.004), androstenedione (p<0.04), and estrone (p<0.03) from baseline within the DHEA group but not within the placebo group. There was a significant increase in DHEA (p<0.0006), DHEA-S (p<0.032), total testosterone (p<0.01), and dihydrotestosterone (p<0.005) in the DHEA group compared with the placebo group. Oral DHEA produces significant increases in circulating DHEA, DHEA-S, testosterone, DHT, and, possibly, androstenedione and estrone levels in premenopausal women with HIV infection. In the current pilot study these hormone changes did not affect the pituitary or adrenal axis or insulin/IGF indices. Long-term studies with larger groups of patients are needed to confirm these data and to determine their clinical significance. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/18810712/Metabolic_and_hormonal_effects_of_oral_DHEA_in_premenopausal_women_with_HIV_infection:_a_randomized_prospective_placebo_controlled_pilot_study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1087175 DB - PRIME DP - Unbound Medicine ER -